Beyond nine years of continuous subthalamic nucleus deep brain stimulation in Parkinson's disease.
Identifieur interne : 001455 ( PubMed/Checkpoint ); précédent : 001454; suivant : 001456Beyond nine years of continuous subthalamic nucleus deep brain stimulation in Parkinson's disease.
Auteurs : Maurizio Zibetti [Italie] ; Aristide Merola ; Laura Rizzi ; Valeria Ricchi ; Serena Angrisano ; Corrado Azzaro ; Carlo Alberto Artusi ; Nichy Arduino ; Alice Marchisio ; Michele Lanotte ; Mario Rizzone ; Leonardo LopianoSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- Activities of Daily Living, Aged, Deep Brain Stimulation (instrumentation), Deep Brain Stimulation (methods), Disease Progression, Dopamine Agents (administration & dosage), Dopamine Agents (adverse effects), Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (therapy), Prospective Studies, Severity of Illness Index, Subthalamic Nucleus (physiology), Subthalamic Nucleus (surgery), Time Factors, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Dopamine Agents.
- chemical , adverse effects : Dopamine Agents.
- diagnosis : Parkinson Disease.
- drug therapy : Parkinson Disease.
- instrumentation : Deep Brain Stimulation.
- methods : Deep Brain Stimulation.
- physiology : Subthalamic Nucleus.
- surgery : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Activities of Daily Living, Aged, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Severity of Illness Index, Time Factors, Treatment Outcome.
Abstract
Deep brain stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson's disease. The benefits of bilateral subthalamic stimulation are well documented, and some studies reported outcomes with a follow-up of 5 to 6 years; nevertheless, few data are available beyond 5 years. We report a long-term prospective evaluation of 14 consecutive parkinsonian patients, treated by bilateral subthalamic stimulation for at least 9 years. Motor symptoms, activity of daily living, and motor complications were evaluated by means of the Unified Parkinson's Disease Rating Scale, while cognition and mood were assessed with a specific neuropsychological test battery; medication intake, stimulation parameters, comorbidity, and adverse events were also recorded. Patients were evaluated before surgery and at 1, 5, and ≥ 9 years after surgery. At last follow-up, deep brain stimulation significantly improved the motor score by 42% compared to baseline, whereas activities of daily living were no longer improved; there was a 39% reduction in the dosage of dopaminergic drugs and a 59% improvement of L-dopa-related motor complications. The neuropsychological assessment showed that 4 patients (29%) developed a significant cognitive decline over the follow-up period. These results indicate a persistent effect of deep brain stimulation of the subthalamic nucleus on the cardinal motor symptoms in advanced Parkinson's disease patients in the long-term; however, a worsening of patients' disability, mainly due to disease progression, was observed.
DOI: 10.1002/mds.23903
PubMed: 22012750
Affiliations:
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Rizzi</name></author><author><name sortKey="Ricchi, Valeria" sort="Ricchi, Valeria" uniqKey="Ricchi V" first="Valeria" last="Ricchi">Valeria Ricchi</name></author><author><name sortKey="Angrisano, Serena" sort="Angrisano, Serena" uniqKey="Angrisano S" first="Serena" last="Angrisano">Serena Angrisano</name></author><author><name sortKey="Azzaro, Corrado" sort="Azzaro, Corrado" uniqKey="Azzaro C" first="Corrado" last="Azzaro">Corrado Azzaro</name></author><author><name sortKey="Artusi, Carlo Alberto" sort="Artusi, Carlo Alberto" uniqKey="Artusi C" first="Carlo Alberto" last="Artusi">Carlo Alberto Artusi</name></author><author><name sortKey="Arduino, Nichy" sort="Arduino, Nichy" uniqKey="Arduino N" first="Nichy" last="Arduino">Nichy Arduino</name></author><author><name sortKey="Marchisio, Alice" sort="Marchisio, Alice" uniqKey="Marchisio A" first="Alice" last="Marchisio">Alice Marchisio</name></author><author><name sortKey="Lanotte, Michele" sort="Lanotte, Michele" uniqKey="Lanotte M" first="Michele" last="Lanotte">Michele Lanotte</name></author><author><name sortKey="Rizzone, Mario" sort="Rizzone, Mario" uniqKey="Rizzone M" first="Mario" last="Rizzone">Mario Rizzone</name></author><author><name sortKey="Lopiano, Leonardo" sort="Lopiano, Leonardo" uniqKey="Lopiano L" first="Leonardo" last="Lopiano">Leonardo Lopiano</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23903</idno><idno type="RBID">pubmed:22012750</idno><idno type="pmid">22012750</idno><idno type="wicri:Area/PubMed/Corpus">000F97</idno><idno type="wicri:Area/PubMed/Curation">000F97</idno><idno type="wicri:Area/PubMed/Checkpoint">001455</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Beyond nine years of continuous subthalamic nucleus deep brain stimulation in Parkinson's disease.</title><author><name sortKey="Zibetti, Maurizio" sort="Zibetti, Maurizio" uniqKey="Zibetti M" first="Maurizio" last="Zibetti">Maurizio Zibetti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neuroscience, University of Torino, Torino, Italy. maurizio.zibetti@gmail.com</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Torino, Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Merola, Aristide" sort="Merola, Aristide" uniqKey="Merola A" first="Aristide" last="Merola">Aristide Merola</name></author><author><name sortKey="Rizzi, Laura" sort="Rizzi, Laura" uniqKey="Rizzi L" first="Laura" last="Rizzi">Laura Rizzi</name></author><author><name sortKey="Ricchi, Valeria" sort="Ricchi, Valeria" uniqKey="Ricchi V" first="Valeria" last="Ricchi">Valeria Ricchi</name></author><author><name sortKey="Angrisano, Serena" sort="Angrisano, Serena" uniqKey="Angrisano S" first="Serena" last="Angrisano">Serena Angrisano</name></author><author><name sortKey="Azzaro, Corrado" sort="Azzaro, Corrado" uniqKey="Azzaro C" first="Corrado" last="Azzaro">Corrado Azzaro</name></author><author><name sortKey="Artusi, Carlo Alberto" sort="Artusi, Carlo Alberto" uniqKey="Artusi C" first="Carlo Alberto" last="Artusi">Carlo Alberto Artusi</name></author><author><name sortKey="Arduino, Nichy" sort="Arduino, Nichy" uniqKey="Arduino N" first="Nichy" last="Arduino">Nichy Arduino</name></author><author><name sortKey="Marchisio, Alice" sort="Marchisio, Alice" uniqKey="Marchisio A" first="Alice" last="Marchisio">Alice Marchisio</name></author><author><name sortKey="Lanotte, Michele" sort="Lanotte, Michele" uniqKey="Lanotte M" first="Michele" last="Lanotte">Michele Lanotte</name></author><author><name sortKey="Rizzone, Mario" sort="Rizzone, Mario" uniqKey="Rizzone M" first="Mario" last="Rizzone">Mario Rizzone</name></author><author><name sortKey="Lopiano, Leonardo" sort="Lopiano, Leonardo" uniqKey="Lopiano L" first="Leonardo" last="Lopiano">Leonardo Lopiano</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Deep Brain Stimulation (instrumentation)</term><term>Deep Brain Stimulation (methods)</term><term>Disease Progression</term><term>Dopamine Agents (administration & dosage)</term><term>Dopamine Agents (adverse effects)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (therapy)</term><term>Prospective Studies</term><term>Severity of Illness Index</term><term>Subthalamic Nucleus (physiology)</term><term>Subthalamic Nucleus (surgery)</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Dopamine Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Dopamine Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Prospective Studies</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson's disease. The benefits of bilateral subthalamic stimulation are well documented, and some studies reported outcomes with a follow-up of 5 to 6 years; nevertheless, few data are available beyond 5 years. We report a long-term prospective evaluation of 14 consecutive parkinsonian patients, treated by bilateral subthalamic stimulation for at least 9 years. Motor symptoms, activity of daily living, and motor complications were evaluated by means of the Unified Parkinson's Disease Rating Scale, while cognition and mood were assessed with a specific neuropsychological test battery; medication intake, stimulation parameters, comorbidity, and adverse events were also recorded. Patients were evaluated before surgery and at 1, 5, and ≥ 9 years after surgery. At last follow-up, deep brain stimulation significantly improved the motor score by 42% compared to baseline, whereas activities of daily living were no longer improved; there was a 39% reduction in the dosage of dopaminergic drugs and a 59% improvement of L-dopa-related motor complications. The neuropsychological assessment showed that 4 patients (29%) developed a significant cognitive decline over the follow-up period. These results indicate a persistent effect of deep brain stimulation of the subthalamic nucleus on the cardinal motor symptoms in advanced Parkinson's disease patients in the long-term; however, a worsening of patients' disability, mainly due to disease progression, was observed.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22012750</PMID><DateCreated><Year>2011</Year><Month>11</Month><Day>24</Day></DateCreated><DateCompleted><Year>2012</Year><Month>04</Month><Day>05</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>13</Issue><PubDate><Year>2011</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Beyond nine years of continuous subthalamic nucleus deep brain stimulation in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>2327-34</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23903</ELocationID><Abstract><AbstractText>Deep brain stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson's disease. The benefits of bilateral subthalamic stimulation are well documented, and some studies reported outcomes with a follow-up of 5 to 6 years; nevertheless, few data are available beyond 5 years. We report a long-term prospective evaluation of 14 consecutive parkinsonian patients, treated by bilateral subthalamic stimulation for at least 9 years. Motor symptoms, activity of daily living, and motor complications were evaluated by means of the Unified Parkinson's Disease Rating Scale, while cognition and mood were assessed with a specific neuropsychological test battery; medication intake, stimulation parameters, comorbidity, and adverse events were also recorded. Patients were evaluated before surgery and at 1, 5, and ≥ 9 years after surgery. At last follow-up, deep brain stimulation significantly improved the motor score by 42% compared to baseline, whereas activities of daily living were no longer improved; there was a 39% reduction in the dosage of dopaminergic drugs and a 59% improvement of L-dopa-related motor complications. The neuropsychological assessment showed that 4 patients (29%) developed a significant cognitive decline over the follow-up period. These results indicate a persistent effect of deep brain stimulation of the subthalamic nucleus on the cardinal motor symptoms in advanced Parkinson's disease patients in the long-term; however, a worsening of patients' disability, mainly due to disease progression, was observed.</AbstractText><CopyrightInformation>Copyright © 2011 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zibetti</LastName><ForeName>Maurizio</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neuroscience, University of Torino, Torino, Italy. maurizio.zibetti@gmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merola</LastName><ForeName>Aristide</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Rizzi</LastName><ForeName>Laura</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Ricchi</LastName><ForeName>Valeria</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Angrisano</LastName><ForeName>Serena</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Azzaro</LastName><ForeName>Corrado</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Artusi</LastName><ForeName>Carlo Alberto</ForeName><Initials>CA</Initials></Author><Author ValidYN="Y"><LastName>Arduino</LastName><ForeName>Nichy</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Marchisio</LastName><ForeName>Alice</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Lanotte</LastName><ForeName>Michele</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Rizzone</LastName><ForeName>Mario</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Lopiano</LastName><ForeName>Leonardo</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>08</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015259">Dopamine Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Mov Disord. 2011 Nov;26(13):2303-4</RefSource><PMID Version="1">22109849</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000203">Activities of Daily Living</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D046690">Deep Brain Stimulation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000295">instrumentation</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018450">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015259">Dopamine Agents</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000008">administration & dosage</QualifierName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005500">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011446">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020531">Subthalamic Nucleus</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>4</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2011</Year><Month>7</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>7</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2011</Year><Month>8</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>4</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.23903</ArticleId><ArticleId IdType="pubmed">22012750</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country><region><li>Piémont</li></region><settlement><li>Turin</li></settlement></list><tree><noCountry><name sortKey="Angrisano, Serena" sort="Angrisano, Serena" uniqKey="Angrisano S" first="Serena" last="Angrisano">Serena Angrisano</name><name sortKey="Arduino, Nichy" sort="Arduino, Nichy" uniqKey="Arduino N" first="Nichy" last="Arduino">Nichy Arduino</name><name sortKey="Artusi, Carlo Alberto" sort="Artusi, Carlo Alberto" uniqKey="Artusi C" first="Carlo Alberto" last="Artusi">Carlo Alberto Artusi</name><name sortKey="Azzaro, Corrado" sort="Azzaro, Corrado" uniqKey="Azzaro C" first="Corrado" last="Azzaro">Corrado Azzaro</name><name sortKey="Lanotte, Michele" sort="Lanotte, Michele" uniqKey="Lanotte M" first="Michele" last="Lanotte">Michele Lanotte</name><name sortKey="Lopiano, Leonardo" sort="Lopiano, Leonardo" uniqKey="Lopiano L" first="Leonardo" last="Lopiano">Leonardo Lopiano</name><name sortKey="Marchisio, Alice" sort="Marchisio, Alice" uniqKey="Marchisio A" first="Alice" last="Marchisio">Alice Marchisio</name><name sortKey="Merola, Aristide" sort="Merola, Aristide" uniqKey="Merola A" first="Aristide" last="Merola">Aristide Merola</name><name sortKey="Ricchi, Valeria" sort="Ricchi, Valeria" uniqKey="Ricchi V" first="Valeria" last="Ricchi">Valeria Ricchi</name><name sortKey="Rizzi, Laura" sort="Rizzi, Laura" uniqKey="Rizzi L" first="Laura" last="Rizzi">Laura Rizzi</name><name sortKey="Rizzone, Mario" sort="Rizzone, Mario" uniqKey="Rizzone M" first="Mario" last="Rizzone">Mario Rizzone</name></noCountry><country name="Italie"><region name="Piémont"><name sortKey="Zibetti, Maurizio" sort="Zibetti, Maurizio" uniqKey="Zibetti M" first="Maurizio" last="Zibetti">Maurizio Zibetti</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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