Abnormal response to cortical activation in early stages of Huntington disease.
Identifieur interne : 000F59 ( PubMed/Checkpoint ); précédent : 000F58; suivant : 000F60Abnormal response to cortical activation in early stages of Huntington disease.
Auteurs : Fanny Mochel [France] ; Tra-My N'Guyen ; Dinesh Deelchand ; Daisy Rinaldi ; Romain Valabregue ; Claire Wary ; Pierre G. Carlier ; Alexandra Durr ; Pierre-Gilles HenrySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Adenosine Triphosphate (metabolism), Case-Control Studies, Cerebral Cortex (metabolism), Cerebral Cortex (physiopathology), Cerebral Cortex (radionuclide imaging), Female, Humans, Huntington Disease (pathology), Huntington Disease (radionuclide imaging), Linear Models, Magnetic Resonance Spectroscopy, Male, Phosphates (metabolism), Phosphocreatine (metabolism), Phosphorus Isotopes (metabolism).
- MESH :
- chemical , metabolism : Adenosine Triphosphate, Phosphates, Phosphocreatine, Phosphorus Isotopes.
- metabolism : Cerebral Cortex.
- pathology : Huntington Disease.
- physiopathology : Cerebral Cortex.
- radionuclide imaging : Cerebral Cortex, Huntington Disease.
- Case-Control Studies, Female, Humans, Linear Models, Magnetic Resonance Spectroscopy, Male.
Abstract
We wished to identify noninvasive in vivo biomarkers of brain energy deficit in Huntington disease.
DOI: 10.1002/mds.25009
PubMed: 22517114
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:22517114Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Abnormal response to cortical activation in early stages of Huntington disease.</title><author><name sortKey="Mochel, Fanny" sort="Mochel, Fanny" uniqKey="Mochel F" first="Fanny" last="Mochel">Fanny Mochel</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR S975, Institut du Cerveau et de la Moelle, Hôpital La Salpêtrière, Paris, France. fanny.mochel@upmc.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR S975, Institut du Cerveau et de la Moelle, Hôpital La Salpêtrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="N Guyen, Tra My" sort="N Guyen, Tra My" uniqKey="N Guyen T" first="Tra-My" last="N'Guyen">Tra-My N'Guyen</name></author><author><name sortKey="Deelchand, Dinesh" sort="Deelchand, Dinesh" uniqKey="Deelchand D" first="Dinesh" last="Deelchand">Dinesh Deelchand</name></author><author><name sortKey="Rinaldi, Daisy" sort="Rinaldi, Daisy" uniqKey="Rinaldi D" first="Daisy" last="Rinaldi">Daisy Rinaldi</name></author><author><name sortKey="Valabregue, Romain" sort="Valabregue, Romain" uniqKey="Valabregue R" first="Romain" last="Valabregue">Romain Valabregue</name></author><author><name sortKey="Wary, Claire" sort="Wary, Claire" uniqKey="Wary C" first="Claire" last="Wary">Claire Wary</name></author><author><name sortKey="Carlier, Pierre G" sort="Carlier, Pierre G" uniqKey="Carlier P" first="Pierre G" last="Carlier">Pierre G. Carlier</name></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name></author><author><name sortKey="Henry, Pierre Gilles" sort="Henry, Pierre Gilles" uniqKey="Henry P" first="Pierre-Gilles" last="Henry">Pierre-Gilles Henry</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.25009</idno><idno type="RBID">pubmed:22517114</idno><idno type="pmid">22517114</idno><idno type="wicri:Area/PubMed/Corpus">000D91</idno><idno type="wicri:Area/PubMed/Curation">000D91</idno><idno type="wicri:Area/PubMed/Checkpoint">000F59</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Abnormal response to cortical activation in early stages of Huntington disease.</title><author><name sortKey="Mochel, Fanny" sort="Mochel, Fanny" uniqKey="Mochel F" first="Fanny" last="Mochel">Fanny Mochel</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR S975, Institut du Cerveau et de la Moelle, Hôpital La Salpêtrière, Paris, France. fanny.mochel@upmc.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR S975, Institut du Cerveau et de la Moelle, Hôpital La Salpêtrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="N Guyen, Tra My" sort="N Guyen, Tra My" uniqKey="N Guyen T" first="Tra-My" last="N'Guyen">Tra-My N'Guyen</name></author><author><name sortKey="Deelchand, Dinesh" sort="Deelchand, Dinesh" uniqKey="Deelchand D" first="Dinesh" last="Deelchand">Dinesh Deelchand</name></author><author><name sortKey="Rinaldi, Daisy" sort="Rinaldi, Daisy" uniqKey="Rinaldi D" first="Daisy" last="Rinaldi">Daisy Rinaldi</name></author><author><name sortKey="Valabregue, Romain" sort="Valabregue, Romain" uniqKey="Valabregue R" first="Romain" last="Valabregue">Romain Valabregue</name></author><author><name sortKey="Wary, Claire" sort="Wary, Claire" uniqKey="Wary C" first="Claire" last="Wary">Claire Wary</name></author><author><name sortKey="Carlier, Pierre G" sort="Carlier, Pierre G" uniqKey="Carlier P" first="Pierre G" last="Carlier">Pierre G. Carlier</name></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name></author><author><name sortKey="Henry, Pierre Gilles" sort="Henry, Pierre Gilles" uniqKey="Henry P" first="Pierre-Gilles" last="Henry">Pierre-Gilles Henry</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Triphosphate (metabolism)</term><term>Case-Control Studies</term><term>Cerebral Cortex (metabolism)</term><term>Cerebral Cortex (physiopathology)</term><term>Cerebral Cortex (radionuclide imaging)</term><term>Female</term><term>Humans</term><term>Huntington Disease (pathology)</term><term>Huntington Disease (radionuclide imaging)</term><term>Linear Models</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Phosphates (metabolism)</term><term>Phosphocreatine (metabolism)</term><term>Phosphorus Isotopes (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenosine Triphosphate</term><term>Phosphates</term><term>Phosphocreatine</term><term>Phosphorus Isotopes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebral Cortex</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Cerebral Cortex</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We wished to identify noninvasive in vivo biomarkers of brain energy deficit in Huntington disease.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22517114</PMID><DateCreated><Year>2012</Year><Month>06</Month><Day>25</Day></DateCreated><DateCompleted><Year>2012</Year><Month>11</Month><Day>13</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>7</Issue><PubDate><Year>2012</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Abnormal response to cortical activation in early stages of Huntington disease.</ArticleTitle><Pagination><MedlinePgn>907-10</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25009</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">We wished to identify noninvasive in vivo biomarkers of brain energy deficit in Huntington disease.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We studied 15 early affected patients (mean motor United Huntington Disease Rating Scale, 18 ± 9) and 15 age- and sex-matched controls. We coupled (31)phosphorus nuclear magnetic resonance spectroscopy with activation of the occipital cortex in order to measure the relative concentrations of adenosine triphosphate, phosphocreatine, and inorganic phosphate before, during, and after visual stimulation.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In controls, we observed an 11% increase in the inorganic phosphate/phosphocreatine ratio (P = .024) and a 13% increase in the inorganic phosphate/adenosine triphosphate ratio (P = .016) during brain activation, reflecting increased adenosine diphosphate concentrations. Subsequently, controls had a return to baseline levels during recovery (P = .012 and .022, respectively). In contrast, both ratios were unchanged in patients during and after visual stimulation.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">(31)Phosphorus nuclear magnetic resonance spectroscopy could provide functional biomarkers of brain energy deficit to monitor therapeutic efficacy in Huntington disease.</AbstractText><CopyrightInformation>Copyright © 2012 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mochel</LastName><ForeName>Fanny</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>INSERM UMR S975, Institut du Cerveau et de la Moelle, Hôpital La Salpêtrière, Paris, France. fanny.mochel@upmc.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>N'Guyen</LastName><ForeName>Tra-My</ForeName><Initials>TM</Initials></Author><Author ValidYN="Y"><LastName>Deelchand</LastName><ForeName>Dinesh</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Rinaldi</LastName><ForeName>Daisy</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Valabregue</LastName><ForeName>Romain</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Wary</LastName><ForeName>Claire</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Carlier</LastName><ForeName>Pierre G</ForeName><Initials>PG</Initials></Author><Author ValidYN="Y"><LastName>Durr</LastName><ForeName>Alexandra</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Henry</LastName><ForeName>Pierre-Gilles</ForeName><Initials>PG</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P41 RR 08079</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS 38672</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>04</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010710">Phosphates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010759">Phosphorus Isotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>020IUV4N33</RegistryNumber><NameOfSubstance UI="D010725">Phosphocreatine</NameOfSubstance></Chemical><Chemical><RegistryNumber>8L70Q75FXE</RegistryNumber><NameOfSubstance UI="D000255">Adenosine Triphosphate</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000255">Adenosine Triphosphate</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016022">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002540">Cerebral Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006816">Huntington Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016014">Linear Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009682">Magnetic Resonance Spectroscopy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010710">Phosphates</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010725">Phosphocreatine</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010759">Phosphorus Isotopes</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>12</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>3</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year><Month>4</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>4</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>4</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>11</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.25009</ArticleId><ArticleId IdType="pubmed">22517114</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Carlier, Pierre G" sort="Carlier, Pierre G" uniqKey="Carlier P" first="Pierre G" last="Carlier">Pierre G. Carlier</name><name sortKey="Deelchand, Dinesh" sort="Deelchand, Dinesh" uniqKey="Deelchand D" first="Dinesh" last="Deelchand">Dinesh Deelchand</name><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name><name sortKey="Henry, Pierre Gilles" sort="Henry, Pierre Gilles" uniqKey="Henry P" first="Pierre-Gilles" last="Henry">Pierre-Gilles Henry</name><name sortKey="N Guyen, Tra My" sort="N Guyen, Tra My" uniqKey="N Guyen T" first="Tra-My" last="N'Guyen">Tra-My N'Guyen</name><name sortKey="Rinaldi, Daisy" sort="Rinaldi, Daisy" uniqKey="Rinaldi D" first="Daisy" last="Rinaldi">Daisy Rinaldi</name><name sortKey="Valabregue, Romain" sort="Valabregue, Romain" uniqKey="Valabregue R" first="Romain" last="Valabregue">Romain Valabregue</name><name sortKey="Wary, Claire" sort="Wary, Claire" uniqKey="Wary C" first="Claire" last="Wary">Claire Wary</name></noCountry><country name="France"><noRegion><name sortKey="Mochel, Fanny" sort="Mochel, Fanny" uniqKey="Mochel F" first="Fanny" last="Mochel">Fanny Mochel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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