Lewy pathology and neurodegeneration in premotor Parkinson's disease.
Identifieur interne : 000D58 ( PubMed/Checkpoint ); précédent : 000D57; suivant : 000D59Lewy pathology and neurodegeneration in premotor Parkinson's disease.
Auteurs : Kelly Del Tredici [Allemagne] ; Heiko BraakSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Humans, Lewy Bodies (pathology), Lewy Body Disease (classification), Lewy Body Disease (metabolism), Lewy Body Disease (pathology), Motor Neurons (pathology), Neurodegenerative Diseases (classification), Neurodegenerative Diseases (pathology), Parkinson Disease (classification), Parkinson Disease (pathology), Parkinson Disease (physiopathology).
- MESH :
- classification : Lewy Body Disease, Neurodegenerative Diseases, Parkinson Disease.
- metabolism : Lewy Body Disease.
- pathology : Lewy Bodies, Lewy Body Disease, Motor Neurons, Neurodegenerative Diseases, Parkinson Disease.
- physiopathology : Parkinson Disease.
- Humans.
Abstract
The foremost motor manifestations of Parkinson's disease are resting tremor, cogwheel rigidity, hypokinesia/bradykinesia, and postural instability. Epidemiological and clinical data reveal that a wide variety of additional complaints (nonmotor symptoms), also considerably impar patients' quality of life parallel to the chronic-progressive neurodegenerative disorder. This article reviews the neuropathology and anatomy of Lewy pathology-related neurodegeneration in relation to selected nonmotro and prodromal dysfunctions.
DOI: 10.1002/mds.24921
PubMed: 22508278
Affiliations:
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