MovDisordV3, PubMed, Checkpoint, bibRecord, 000A84

Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease.

Identifieur interne : 000A84 ( PubMed/Checkpoint ); précédent : 000A83; suivant : 000A85

Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease.

Auteurs : Natalja Funk [Allemagne] ; Peter Wieghofer ; Sabrina Grimm ; Richard Schaefer ; Hans-Jörg Bühring ; Thomas Gasser ; Saskia Biskup

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.

RBID : pubmed:23401086

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Female, Flow Cytometry, Hematopoietic Stem Cells (immunology), Hematopoietic Stem Cells (physiology), Humans, Male, Middle Aged, Monocytes (immunology), Monocytes (physiology), Parkinson Disease (genetics), Parkinson Disease (pathology), Protein-Serine-Threonine Kinases (genetics), Receptors, CCR2 (metabolism), Statistics, Nonparametric.
MESH :
- chemical , genetics : Protein-Serine-Threonine Kinases.
- genetics : Parkinson Disease.
- immunology : Hematopoietic Stem Cells, Monocytes.
- chemical , metabolism : Receptors, CCR2.
- pathology : Parkinson Disease.
- physiology : Hematopoietic Stem Cells, Monocytes.
- Adult, Aged, Aged, 80 and over, Female, Flow Cytometry, Humans, Male, Middle Aged, Statistics, Nonparametric.

Abstract

Emerging evidence has highlighted the pivotal role of the immune system in neurodegenerative diseases. This study investigated the impact of progressive neurodegeneration on the differentiation and development of hematopoietic stem cells in the peripheral blood of Parkinson's patients.

DOI: 10.1002/mds.25300
PubMed: 23401086

Affiliations:

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pubmed:23401086

Le document en format XML

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<author><name sortKey="Funk, Natalja" sort="Funk, Natalja" uniqKey="Funk N" first="Natalja" last="Funk">Natalja Funk</name>
<affiliation wicri:level="3"><nlm:affiliation>Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, Tuebingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, Tuebingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
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<author><name sortKey="Wieghofer, Peter" sort="Wieghofer, Peter" uniqKey="Wieghofer P" first="Peter" last="Wieghofer">Peter Wieghofer</name>
</author>
<author><name sortKey="Grimm, Sabrina" sort="Grimm, Sabrina" uniqKey="Grimm S" first="Sabrina" last="Grimm">Sabrina Grimm</name>
</author>
<author><name sortKey="Schaefer, Richard" sort="Schaefer, Richard" uniqKey="Schaefer R" first="Richard" last="Schaefer">Richard Schaefer</name>
</author>
<author><name sortKey="Buhring, Hans Jorg" sort="Buhring, Hans Jorg" uniqKey="Buhring H" first="Hans-Jörg" last="Bühring">Hans-Jörg Bühring</name>
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<author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
</author>
<author><name sortKey="Biskup, Saskia" sort="Biskup, Saskia" uniqKey="Biskup S" first="Saskia" last="Biskup">Saskia Biskup</name>
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<author><name sortKey="Funk, Natalja" sort="Funk, Natalja" uniqKey="Funk N" first="Natalja" last="Funk">Natalja Funk</name>
<affiliation wicri:level="3"><nlm:affiliation>Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, Tuebingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, Tuebingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
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<author><name sortKey="Wieghofer, Peter" sort="Wieghofer, Peter" uniqKey="Wieghofer P" first="Peter" last="Wieghofer">Peter Wieghofer</name>
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<author><name sortKey="Grimm, Sabrina" sort="Grimm, Sabrina" uniqKey="Grimm S" first="Sabrina" last="Grimm">Sabrina Grimm</name>
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<author><name sortKey="Schaefer, Richard" sort="Schaefer, Richard" uniqKey="Schaefer R" first="Richard" last="Schaefer">Richard Schaefer</name>
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<author><name sortKey="Buhring, Hans Jorg" sort="Buhring, Hans Jorg" uniqKey="Buhring H" first="Hans-Jörg" last="Bühring">Hans-Jörg Bühring</name>
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<author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
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<author><name sortKey="Biskup, Saskia" sort="Biskup, Saskia" uniqKey="Biskup S" first="Saskia" last="Biskup">Saskia Biskup</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2013" type="published">2013</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Flow Cytometry</term>
<term>Hematopoietic Stem Cells (immunology)</term>
<term>Hematopoietic Stem Cells (physiology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Monocytes (immunology)</term>
<term>Monocytes (physiology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (pathology)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Receptors, CCR2 (metabolism)</term>
<term>Statistics, Nonparametric</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Hematopoietic Stem Cells</term>
<term>Monocytes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, CCR2</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hematopoietic Stem Cells</term>
<term>Monocytes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Flow Cytometry</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Statistics, Nonparametric</term>
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<front><div type="abstract" xml:lang="en">Emerging evidence has highlighted the pivotal role of the immune system in neurodegenerative diseases. This study investigated the impact of progressive neurodegeneration on the differentiation and development of hematopoietic stem cells in the peripheral blood of Parkinson's patients.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23401086</PMID>
<DateCreated><Year>2013</Year>
<Month>03</Month>
<Day>25</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>09</Month>
<Day>20</Day>
</DateCompleted>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>28</Volume>
<Issue>3</Issue>
<PubDate><Year>2013</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>392-5</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25300</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Emerging evidence has highlighted the pivotal role of the immune system in neurodegenerative diseases. This study investigated the impact of progressive neurodegeneration on the differentiation and development of hematopoietic stem cells in the peripheral blood of Parkinson's patients.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">A colony-forming cell assay was established to study hematopoietic stem cells from venous blood of Parkinson's patients, and flow cytometry was used to analyze the expression of chemokine receptors on monocytes.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We demonstrate that there is strong upregulation in the percentage of monocyte precursors in the peripheral blood of Parkinson's patients and asymptomatic high-risk individuals. We identify the receptor CCR2 as undergoing strong upregulation on the surface of classical monocytes in Parkinson's patients.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The association between blood cell development and progressive cell death in the brain of Parkinson's patients should be further investigated as a potential dynamic biomarker and indicator of disease progression.</AbstractText>
<CopyrightInformation>Copyright © 2012 Movement Disorders Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Funk</LastName>
<ForeName>Natalja</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, Tuebingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wieghofer</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Grimm</LastName>
<ForeName>Sabrina</ForeName>
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<Author ValidYN="Y"><LastName>Schaefer</LastName>
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<Author ValidYN="Y"><LastName>Bühring</LastName>
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<Author ValidYN="Y"><LastName>Gasser</LastName>
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<Author ValidYN="Y"><LastName>Biskup</LastName>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>02</Month>
<Day>07</Day>
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</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C515334">CCR2 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054390">Receptors, CCR2</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="C495280">LRRK2 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
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</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005434">Flow Cytometry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006412">Hematopoietic Stem Cells</DescriptorName>
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<QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName>
</MeshHeading>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009000">Monocytes</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000276">immunology</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D017346">Protein-Serine-Threonine Kinases</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D018709">Statistics, Nonparametric</DescriptorName>
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<tree><noCountry><name sortKey="Biskup, Saskia" sort="Biskup, Saskia" uniqKey="Biskup S" first="Saskia" last="Biskup">Saskia Biskup</name>
<name sortKey="Buhring, Hans Jorg" sort="Buhring, Hans Jorg" uniqKey="Buhring H" first="Hans-Jörg" last="Bühring">Hans-Jörg Bühring</name>
<name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
<name sortKey="Grimm, Sabrina" sort="Grimm, Sabrina" uniqKey="Grimm S" first="Sabrina" last="Grimm">Sabrina Grimm</name>
<name sortKey="Schaefer, Richard" sort="Schaefer, Richard" uniqKey="Schaefer R" first="Richard" last="Schaefer">Richard Schaefer</name>
<name sortKey="Wieghofer, Peter" sort="Wieghofer, Peter" uniqKey="Wieghofer P" first="Peter" last="Wieghofer">Peter Wieghofer</name>
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<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Funk, Natalja" sort="Funk, Natalja" uniqKey="Funk N" first="Natalja" last="Funk">Natalja Funk</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease.

Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki