Cumulative exposure to lead and cognition in persons with Parkinson's disease.
Identifieur interne : 000A51 ( PubMed/Checkpoint ); précédent : 000A50; suivant : 000A52Cumulative exposure to lead and cognition in persons with Parkinson's disease.
Auteurs : Jennifer Weuve [États-Unis] ; Daniel Z. Press ; Francine Grodstein ; Robert O. Wright ; Howard Hu ; Marc G. WeisskopfSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- Age of Onset, Aged, Aged, 80 and over, Bone and Bones (chemistry), Cognition (physiology), Educational Status, Environmental Exposure, Female, Humans, Lead (analysis), Lead Poisoning, Nervous System (complications), Lead Poisoning, Nervous System (psychology), Learning (physiology), Male, Memory (physiology), Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (psychology), Reproducibility of Results, Smoking (epidemiology), Spectrometry, X-Ray Emission, Telephone, Trail Making Test, Verbal Behavior (physiology).
- MESH :
- chemical , analysis : Lead.
- chemistry : Bone and Bones.
- complications : Lead Poisoning, Nervous System, Parkinson Disease.
- epidemiology : Smoking.
- physiology : Cognition, Learning, Memory, Verbal Behavior.
- psychology : Lead Poisoning, Nervous System, Parkinson Disease.
- Age of Onset, Aged, Aged, 80 and over, Educational Status, Environmental Exposure, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Reproducibility of Results, Spectrometry, X-Ray Emission, Telephone, Trail Making Test.
Abstract
Dementia is an important consequence of Parkinson's disease (PD), with few known modifiable risk factors. Cumulative exposure to lead, at levels experienced in the community, may exacerbate PD-related neural dysfunction, resulting in impaired cognition. Among 101 persons with PD ("cases") and, separately, 50 persons without PD ("controls"), we evaluated cumulative lead exposure, gauged by tibia and patella bone lead concentrations, in relation to cognitive function, assessed using a telephone battery developed and validated in a separate sample of PD patients. We also assessed the interaction between lead and case-control status. After multivariable adjustment, higher tibia bone lead concentration among PD cases was associated with worse performance on all of the individual telephone tests. In particular, tibia lead levels corresponded to significantly worse performance on a telephone analog of the Mini-Mental State Examination and tests of working memory and attention. Moreover, higher tibia bone lead concentration was associated with significantly worse global composite score encompassing all the cognitive tests (P = 0.04). The magnitude of association per standard deviation increment in tibia bone lead level was equivalent to the difference in global scores among controls in our study, who were approximately 7 years apart in age. The tibia lead-cognition association was notably stronger within cases than within controls (P(difference) = 0.06). Patella bone lead concentration was not consistently associated with performance on the tests. These data provide evidence suggesting that cumulative exposure to lead may result in worsened cognition among persons with PD.
DOI: 10.1002/mds.25247
PubMed: 23143985
Affiliations:
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pubmed:23143985Le document en format XML
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Press</name></author><author><name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name></author><author><name sortKey="Wright, Robert O" sort="Wright, Robert O" uniqKey="Wright R" first="Robert O" last="Wright">Robert O. Wright</name></author><author><name sortKey="Hu, Howard" sort="Hu, Howard" uniqKey="Hu H" first="Howard" last="Hu">Howard Hu</name></author><author><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G" last="Weisskopf">Marc G. Weisskopf</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="doi">10.1002/mds.25247</idno><idno type="RBID">pubmed:23143985</idno><idno type="pmid">23143985</idno><idno type="wicri:Area/PubMed/Corpus">000B70</idno><idno type="wicri:Area/PubMed/Curation">000B70</idno><idno type="wicri:Area/PubMed/Checkpoint">000A51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cumulative exposure to lead and cognition in persons with Parkinson's disease.</title><author><name sortKey="Weuve, Jennifer" sort="Weuve, Jennifer" uniqKey="Weuve J" first="Jennifer" last="Weuve">Jennifer Weuve</name><affiliation wicri:level="1"><nlm:affiliation>Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois 60612, USA. jennifer_weuve@rush.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois 60612</wicri:regionArea><wicri:noRegion>Illinois 60612</wicri:noRegion></affiliation></author><author><name sortKey="Press, Daniel Z" sort="Press, Daniel Z" uniqKey="Press D" first="Daniel Z" last="Press">Daniel Z. Press</name></author><author><name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name></author><author><name sortKey="Wright, Robert O" sort="Wright, Robert O" uniqKey="Wright R" first="Robert O" last="Wright">Robert O. Wright</name></author><author><name sortKey="Hu, Howard" sort="Hu, Howard" uniqKey="Hu H" first="Howard" last="Hu">Howard Hu</name></author><author><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G" last="Weisskopf">Marc G. Weisskopf</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Bone and Bones (chemistry)</term><term>Cognition (physiology)</term><term>Educational Status</term><term>Environmental Exposure</term><term>Female</term><term>Humans</term><term>Lead (analysis)</term><term>Lead Poisoning, Nervous System (complications)</term><term>Lead Poisoning, Nervous System (psychology)</term><term>Learning (physiology)</term><term>Male</term><term>Memory (physiology)</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (psychology)</term><term>Reproducibility of Results</term><term>Smoking (epidemiology)</term><term>Spectrometry, X-Ray Emission</term><term>Telephone</term><term>Trail Making Test</term><term>Verbal Behavior (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Lead</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Bone and Bones</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Lead Poisoning, Nervous System</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term><term>Learning</term><term>Memory</term><term>Verbal Behavior</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Lead Poisoning, Nervous System</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Educational Status</term><term>Environmental Exposure</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Reproducibility of Results</term><term>Spectrometry, X-Ray Emission</term><term>Telephone</term><term>Trail Making Test</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dementia is an important consequence of Parkinson's disease (PD), with few known modifiable risk factors. Cumulative exposure to lead, at levels experienced in the community, may exacerbate PD-related neural dysfunction, resulting in impaired cognition. Among 101 persons with PD ("cases") and, separately, 50 persons without PD ("controls"), we evaluated cumulative lead exposure, gauged by tibia and patella bone lead concentrations, in relation to cognitive function, assessed using a telephone battery developed and validated in a separate sample of PD patients. We also assessed the interaction between lead and case-control status. After multivariable adjustment, higher tibia bone lead concentration among PD cases was associated with worse performance on all of the individual telephone tests. In particular, tibia lead levels corresponded to significantly worse performance on a telephone analog of the Mini-Mental State Examination and tests of working memory and attention. Moreover, higher tibia bone lead concentration was associated with significantly worse global composite score encompassing all the cognitive tests (P = 0.04). The magnitude of association per standard deviation increment in tibia bone lead level was equivalent to the difference in global scores among controls in our study, who were approximately 7 years apart in age. The tibia lead-cognition association was notably stronger within cases than within controls (P(difference) = 0.06). Patella bone lead concentration was not consistently associated with performance on the tests. These data provide evidence suggesting that cumulative exposure to lead may result in worsened cognition among persons with PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23143985</PMID><DateCreated><Year>2013</Year><Month>02</Month><Day>25</Day></DateCreated><DateCompleted><Year>2013</Year><Month>08</Month><Day>06</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>2</Issue><PubDate><Year>2013</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Cumulative exposure to lead and cognition in persons with Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>176-82</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25247</ELocationID><Abstract><AbstractText>Dementia is an important consequence of Parkinson's disease (PD), with few known modifiable risk factors. Cumulative exposure to lead, at levels experienced in the community, may exacerbate PD-related neural dysfunction, resulting in impaired cognition. Among 101 persons with PD ("cases") and, separately, 50 persons without PD ("controls"), we evaluated cumulative lead exposure, gauged by tibia and patella bone lead concentrations, in relation to cognitive function, assessed using a telephone battery developed and validated in a separate sample of PD patients. We also assessed the interaction between lead and case-control status. After multivariable adjustment, higher tibia bone lead concentration among PD cases was associated with worse performance on all of the individual telephone tests. In particular, tibia lead levels corresponded to significantly worse performance on a telephone analog of the Mini-Mental State Examination and tests of working memory and attention. Moreover, higher tibia bone lead concentration was associated with significantly worse global composite score encompassing all the cognitive tests (P = 0.04). The magnitude of association per standard deviation increment in tibia bone lead level was equivalent to the difference in global scores among controls in our study, who were approximately 7 years apart in age. The tibia lead-cognition association was notably stronger within cases than within controls (P(difference) = 0.06). Patella bone lead concentration was not consistently associated with performance on the tests. These data provide evidence suggesting that cumulative exposure to lead may result in worsened cognition among persons with PD.</AbstractText><CopyrightInformation>Copyright © 2012 Movement Disorders Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Weuve</LastName><ForeName>Jennifer</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois 60612, USA. jennifer_weuve@rush.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Press</LastName><ForeName>Daniel Z</ForeName><Initials>DZ</Initials></Author><Author ValidYN="Y"><LastName>Grodstein</LastName><ForeName>Francine</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Wright</LastName><ForeName>Robert O</ForeName><Initials>RO</Initials></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Howard</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Weisskopf</LastName><ForeName>Marc G</ForeName><Initials>MG</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P30 ES000002</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 ES017885</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30ES000002</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30ES017885</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 ES010798</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01ES010798</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>11</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>2P299V784P</RegistryNumber><NameOfSubstance UI="D007854">Lead</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2004 Sep;19(9):1043-9</RefSource><PMID Version="1">15372593</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Gerontol A Biol Sci Med Sci. 2004 Aug;59(8):864-70</RefSource><PMID Version="1">15345740</PMID></CommentsCorrections><CommentsCorrections 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MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008568">Memory</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015203">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012907">Smoking</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013052">Spectrometry, X-Ray Emission</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013689">Telephone</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014145">Trail Making Test</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014705">Verbal Behavior</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS411433</OtherID><OtherID Source="NLM">PMC3581753</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>5</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>8</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>9</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year><Month>11</Month><Day>9</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>11</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>11</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.25247</ArticleId><ArticleId IdType="pubmed">23143985</ArticleId><ArticleId IdType="pmc">PMC3581753</ArticleId><ArticleId IdType="mid">NIHMS411433</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name><name sortKey="Hu, Howard" sort="Hu, Howard" uniqKey="Hu H" first="Howard" last="Hu">Howard Hu</name><name sortKey="Press, Daniel Z" sort="Press, Daniel Z" uniqKey="Press D" first="Daniel Z" last="Press">Daniel Z. Press</name><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G" last="Weisskopf">Marc G. Weisskopf</name><name sortKey="Wright, Robert O" sort="Wright, Robert O" uniqKey="Wright R" first="Robert O" last="Wright">Robert O. Wright</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Weuve, Jennifer" sort="Weuve, Jennifer" uniqKey="Weuve J" first="Jennifer" last="Weuve">Jennifer Weuve</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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