Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations.
Identifieur interne : 000877 ( PubMed/Checkpoint ); précédent : 000876; suivant : 000878Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations.
Auteurs : Roy N. Alcalay [États-Unis] ; Anat Mirelman ; Rachel Saunders-Pullman ; Ming-X Tang ; Helen Mejia Santana ; Deborah Raymond ; Ernest Roos ; Martha Orbe-Reilly ; Tanya Gurevich ; Anat Bar Shira ; Mali Gana Weisz ; Kira Yasinovsky ; Maayan Zalis ; Avner Thaler ; Andres Deik ; Matthew James Barrett ; Jose Cabassa ; Mark Groves ; Ann L. Hunt ; Naomi Lubarr ; Marta San Luciano ; Joan Miravite ; Christina Palmese ; Rivka Sachdev ; Harini Sarva ; Lawrence Severt ; Vicki Shanker ; Matthew Carrington Swan ; Jeannie Soto-Valencia ; Brooke Johannes ; Robert Ortega ; Stanley Fahn ; Lucien Cote ; Cheryl Waters ; Pietro Mazzoni ; Blair Ford ; Elan Louis ; Oren Levy ; Llency Rosado ; Diana Ruiz ; Tsvyatko Dorovski ; Michael Pauciulo ; William Nichols ; Avi Orr-Urtreger ; Laurie Ozelius ; Lorraine Clark ; Nir Giladi ; Susan Bressman ; Karen S. MarderSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Female, Genotype, Glycine (genetics), Humans, Jews (genetics), Male, Middle Aged, Mutation (genetics), Parkinson Disease (ethnology), Parkinson Disease (genetics), Phenotype, Protein-Serine-Threonine Kinases (genetics), Questionnaires, Regression Analysis, Serine (genetics), Severity of Illness Index.
- MESH :
- chemical , genetics : Glycine, Protein-Serine-Threonine Kinases, Serine.
- ethnology : Parkinson Disease.
- genetics : Jews, Mutation, Parkinson Disease.
- Aged, Female, Genotype, Humans, Male, Middle Aged, Phenotype, Questionnaires, Regression Analysis, Severity of Illness Index.
Abstract
The phenotype of Parkinson's disease (PD) in patients with and without leucine-rich repeat kinase 2 (LRRK2) G2019S mutations reportedly is similar; however, large, uniformly evaluated series are lacking. The objective of this study was to characterize the clinical phenotype of Ashkenazi Jewish (AJ) PD carriers of the LRRK2 G2019S mutation. We studied 553 AJ PD patients, including 65 patients who were previously reported, from three sites (two in New York and one in Tel-Aviv). Glucocerebrosidase (GBA) mutation carriers were excluded. Evaluations included the Montreal Cognitive Assessment (MoCA), the Unified Parkinson's Disease Rating Scale (UPDRS), the Geriatric Depression Scale (GDS) and the Non-Motor Symptoms (NMS) questionnaire. Regression models were constructed to test the association between clinical and demographic features and LRRK2 status (outcome) in 488 newly recruited participants. LRRK2 G2019S carriers (n = 97) and non-carriers (n = 391) were similar in age and age at onset of PD. Carriers had longer disease duration (8.6 years vs. 6.1 years; P < 0.001), were more likely to be women (51.5% vs. 37.9%; P = 0.015), and more often reported first symptoms in the lower extremities (40.0% vs. 19.2%; P < 0.001). In logistic models that were adjusted for age, disease duration, sex, education, and site, carriers were more likely to have lower extremity onset (P < 0.001), postural instability and gait difficulty (PIGD) (P = 0.043), and a persistent levodopa response for >5 years (P = 0.042). Performance on the UPDRS, MoCA, GDS, and NMS did not differ by mutation status. PD in AJ LRRK2 G2019S mutation carriers is similar to idiopathic PD but is characterized by more frequent lower extremity involvement at onset and PIGD without the associated cognitive impairment.
DOI: 10.1002/mds.25647
PubMed: 24243757
Affiliations:
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Alcalay</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Mirelman, Anat" sort="Mirelman, Anat" uniqKey="Mirelman A" first="Anat" last="Mirelman">Anat Mirelman</name></author><author><name sortKey="Saunders Pullman, Rachel" sort="Saunders Pullman, Rachel" uniqKey="Saunders Pullman R" first="Rachel" last="Saunders-Pullman">Rachel Saunders-Pullman</name></author><author><name sortKey="Tang, Ming X" sort="Tang, Ming X" uniqKey="Tang M" first="Ming-X" last="Tang">Ming-X Tang</name></author><author><name sortKey="Mejia Santana, Helen" sort="Mejia Santana, Helen" uniqKey="Mejia Santana H" first="Helen" last="Mejia Santana">Helen Mejia Santana</name></author><author><name sortKey="Raymond, Deborah" sort="Raymond, Deborah" uniqKey="Raymond D" first="Deborah" last="Raymond">Deborah Raymond</name></author><author><name sortKey="Roos, Ernest" sort="Roos, Ernest" uniqKey="Roos E" first="Ernest" last="Roos">Ernest Roos</name></author><author><name sortKey="Orbe Reilly, Martha" sort="Orbe Reilly, Martha" uniqKey="Orbe Reilly M" first="Martha" last="Orbe-Reilly">Martha Orbe-Reilly</name></author><author><name sortKey="Gurevich, Tanya" sort="Gurevich, Tanya" uniqKey="Gurevich T" first="Tanya" last="Gurevich">Tanya Gurevich</name></author><author><name sortKey="Bar Shira, Anat" sort="Bar Shira, Anat" uniqKey="Bar Shira A" first="Anat" last="Bar Shira">Anat Bar Shira</name></author><author><name sortKey="Gana Weisz, Mali" sort="Gana Weisz, Mali" uniqKey="Gana Weisz M" first="Mali" last="Gana Weisz">Mali Gana Weisz</name></author><author><name sortKey="Yasinovsky, Kira" sort="Yasinovsky, Kira" uniqKey="Yasinovsky K" first="Kira" last="Yasinovsky">Kira Yasinovsky</name></author><author><name sortKey="Zalis, Maayan" sort="Zalis, Maayan" uniqKey="Zalis M" first="Maayan" last="Zalis">Maayan Zalis</name></author><author><name sortKey="Thaler, Avner" sort="Thaler, Avner" uniqKey="Thaler A" first="Avner" last="Thaler">Avner Thaler</name></author><author><name sortKey="Deik, Andres" sort="Deik, Andres" uniqKey="Deik A" first="Andres" last="Deik">Andres Deik</name></author><author><name sortKey="Barrett, Matthew James" sort="Barrett, Matthew James" uniqKey="Barrett M" first="Matthew James" last="Barrett">Matthew James Barrett</name></author><author><name sortKey="Cabassa, Jose" sort="Cabassa, Jose" uniqKey="Cabassa J" first="Jose" last="Cabassa">Jose Cabassa</name></author><author><name sortKey="Groves, Mark" sort="Groves, Mark" uniqKey="Groves M" first="Mark" last="Groves">Mark Groves</name></author><author><name sortKey="Hunt, Ann L" sort="Hunt, Ann L" uniqKey="Hunt A" first="Ann L" last="Hunt">Ann L. Hunt</name></author><author><name sortKey="Lubarr, Naomi" sort="Lubarr, Naomi" uniqKey="Lubarr N" first="Naomi" last="Lubarr">Naomi Lubarr</name></author><author><name sortKey="San Luciano, Marta" sort="San Luciano, Marta" uniqKey="San Luciano M" first="Marta" last="San Luciano">Marta San Luciano</name></author><author><name sortKey="Miravite, Joan" sort="Miravite, Joan" uniqKey="Miravite J" first="Joan" last="Miravite">Joan Miravite</name></author><author><name sortKey="Palmese, Christina" sort="Palmese, Christina" uniqKey="Palmese C" first="Christina" last="Palmese">Christina Palmese</name></author><author><name sortKey="Sachdev, Rivka" sort="Sachdev, Rivka" uniqKey="Sachdev R" first="Rivka" last="Sachdev">Rivka Sachdev</name></author><author><name sortKey="Sarva, Harini" sort="Sarva, Harini" uniqKey="Sarva H" first="Harini" last="Sarva">Harini Sarva</name></author><author><name sortKey="Severt, Lawrence" sort="Severt, Lawrence" uniqKey="Severt L" first="Lawrence" last="Severt">Lawrence Severt</name></author><author><name sortKey="Shanker, Vicki" sort="Shanker, Vicki" uniqKey="Shanker V" first="Vicki" last="Shanker">Vicki Shanker</name></author><author><name sortKey="Swan, Matthew Carrington" sort="Swan, Matthew Carrington" uniqKey="Swan M" first="Matthew Carrington" last="Swan">Matthew Carrington Swan</name></author><author><name sortKey="Soto Valencia, Jeannie" sort="Soto Valencia, Jeannie" uniqKey="Soto Valencia J" first="Jeannie" last="Soto-Valencia">Jeannie Soto-Valencia</name></author><author><name sortKey="Johannes, Brooke" sort="Johannes, Brooke" uniqKey="Johannes B" first="Brooke" last="Johannes">Brooke Johannes</name></author><author><name sortKey="Ortega, Robert" sort="Ortega, Robert" uniqKey="Ortega R" first="Robert" last="Ortega">Robert Ortega</name></author><author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name></author><author><name sortKey="Cote, Lucien" sort="Cote, Lucien" uniqKey="Cote L" first="Lucien" last="Cote">Lucien Cote</name></author><author><name sortKey="Waters, Cheryl" sort="Waters, Cheryl" uniqKey="Waters C" first="Cheryl" last="Waters">Cheryl Waters</name></author><author><name sortKey="Mazzoni, Pietro" sort="Mazzoni, Pietro" uniqKey="Mazzoni P" first="Pietro" last="Mazzoni">Pietro Mazzoni</name></author><author><name sortKey="Ford, Blair" sort="Ford, Blair" uniqKey="Ford B" first="Blair" last="Ford">Blair Ford</name></author><author><name sortKey="Louis, Elan" sort="Louis, Elan" uniqKey="Louis E" first="Elan" last="Louis">Elan Louis</name></author><author><name sortKey="Levy, Oren" sort="Levy, Oren" uniqKey="Levy O" first="Oren" last="Levy">Oren Levy</name></author><author><name sortKey="Rosado, Llency" sort="Rosado, Llency" uniqKey="Rosado L" first="Llency" last="Rosado">Llency Rosado</name></author><author><name sortKey="Ruiz, Diana" sort="Ruiz, Diana" uniqKey="Ruiz D" first="Diana" last="Ruiz">Diana Ruiz</name></author><author><name sortKey="Dorovski, Tsvyatko" sort="Dorovski, Tsvyatko" uniqKey="Dorovski T" first="Tsvyatko" last="Dorovski">Tsvyatko Dorovski</name></author><author><name sortKey="Pauciulo, Michael" sort="Pauciulo, Michael" uniqKey="Pauciulo M" first="Michael" last="Pauciulo">Michael Pauciulo</name></author><author><name sortKey="Nichols, William" sort="Nichols, William" uniqKey="Nichols W" first="William" last="Nichols">William Nichols</name></author><author><name sortKey="Orr Urtreger, Avi" sort="Orr Urtreger, Avi" uniqKey="Orr Urtreger A" first="Avi" last="Orr-Urtreger">Avi Orr-Urtreger</name></author><author><name sortKey="Ozelius, Laurie" sort="Ozelius, Laurie" uniqKey="Ozelius L" first="Laurie" last="Ozelius">Laurie Ozelius</name></author><author><name sortKey="Clark, Lorraine" sort="Clark, Lorraine" uniqKey="Clark L" first="Lorraine" last="Clark">Lorraine Clark</name></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name></author><author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name></author><author><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S" last="Marder">Karen S. Marder</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24243757</idno><idno type="pmid">24243757</idno><idno type="doi">10.1002/mds.25647</idno><idno type="wicri:Area/PubMed/Corpus">000676</idno><idno type="wicri:Area/PubMed/Curation">000676</idno><idno type="wicri:Area/PubMed/Checkpoint">000877</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations.</title><author><name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N" last="Alcalay">Roy N. Alcalay</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Mirelman, Anat" sort="Mirelman, Anat" uniqKey="Mirelman A" first="Anat" last="Mirelman">Anat Mirelman</name></author><author><name sortKey="Saunders Pullman, Rachel" sort="Saunders Pullman, Rachel" uniqKey="Saunders Pullman R" first="Rachel" last="Saunders-Pullman">Rachel Saunders-Pullman</name></author><author><name sortKey="Tang, Ming X" sort="Tang, Ming X" uniqKey="Tang M" first="Ming-X" last="Tang">Ming-X Tang</name></author><author><name sortKey="Mejia Santana, Helen" sort="Mejia Santana, Helen" uniqKey="Mejia Santana H" first="Helen" last="Mejia Santana">Helen Mejia Santana</name></author><author><name sortKey="Raymond, Deborah" sort="Raymond, Deborah" uniqKey="Raymond D" first="Deborah" last="Raymond">Deborah Raymond</name></author><author><name sortKey="Roos, Ernest" sort="Roos, Ernest" uniqKey="Roos E" first="Ernest" last="Roos">Ernest Roos</name></author><author><name sortKey="Orbe Reilly, Martha" sort="Orbe Reilly, Martha" uniqKey="Orbe Reilly M" first="Martha" last="Orbe-Reilly">Martha Orbe-Reilly</name></author><author><name sortKey="Gurevich, Tanya" sort="Gurevich, Tanya" uniqKey="Gurevich T" first="Tanya" last="Gurevich">Tanya Gurevich</name></author><author><name sortKey="Bar Shira, Anat" sort="Bar Shira, Anat" uniqKey="Bar Shira A" first="Anat" last="Bar Shira">Anat Bar Shira</name></author><author><name sortKey="Gana Weisz, Mali" sort="Gana Weisz, Mali" uniqKey="Gana Weisz M" first="Mali" last="Gana Weisz">Mali Gana Weisz</name></author><author><name sortKey="Yasinovsky, Kira" sort="Yasinovsky, Kira" uniqKey="Yasinovsky K" first="Kira" last="Yasinovsky">Kira Yasinovsky</name></author><author><name sortKey="Zalis, Maayan" sort="Zalis, Maayan" uniqKey="Zalis M" first="Maayan" last="Zalis">Maayan Zalis</name></author><author><name sortKey="Thaler, Avner" sort="Thaler, Avner" uniqKey="Thaler A" first="Avner" last="Thaler">Avner Thaler</name></author><author><name sortKey="Deik, Andres" sort="Deik, Andres" uniqKey="Deik A" first="Andres" last="Deik">Andres Deik</name></author><author><name sortKey="Barrett, Matthew James" sort="Barrett, Matthew James" uniqKey="Barrett M" first="Matthew James" last="Barrett">Matthew James Barrett</name></author><author><name sortKey="Cabassa, Jose" sort="Cabassa, Jose" uniqKey="Cabassa J" first="Jose" last="Cabassa">Jose Cabassa</name></author><author><name sortKey="Groves, Mark" sort="Groves, Mark" uniqKey="Groves M" first="Mark" last="Groves">Mark Groves</name></author><author><name sortKey="Hunt, Ann L" sort="Hunt, Ann L" uniqKey="Hunt A" first="Ann L" last="Hunt">Ann L. Hunt</name></author><author><name sortKey="Lubarr, Naomi" sort="Lubarr, Naomi" uniqKey="Lubarr N" first="Naomi" last="Lubarr">Naomi Lubarr</name></author><author><name sortKey="San Luciano, Marta" sort="San Luciano, Marta" uniqKey="San Luciano M" first="Marta" last="San Luciano">Marta San Luciano</name></author><author><name sortKey="Miravite, Joan" sort="Miravite, Joan" uniqKey="Miravite J" first="Joan" last="Miravite">Joan Miravite</name></author><author><name sortKey="Palmese, Christina" sort="Palmese, Christina" uniqKey="Palmese C" first="Christina" last="Palmese">Christina Palmese</name></author><author><name sortKey="Sachdev, Rivka" sort="Sachdev, Rivka" uniqKey="Sachdev R" first="Rivka" last="Sachdev">Rivka Sachdev</name></author><author><name sortKey="Sarva, Harini" sort="Sarva, Harini" uniqKey="Sarva H" first="Harini" last="Sarva">Harini Sarva</name></author><author><name sortKey="Severt, Lawrence" sort="Severt, Lawrence" uniqKey="Severt L" first="Lawrence" last="Severt">Lawrence Severt</name></author><author><name sortKey="Shanker, Vicki" sort="Shanker, Vicki" uniqKey="Shanker V" first="Vicki" last="Shanker">Vicki Shanker</name></author><author><name sortKey="Swan, Matthew Carrington" sort="Swan, Matthew Carrington" uniqKey="Swan M" first="Matthew Carrington" last="Swan">Matthew Carrington Swan</name></author><author><name sortKey="Soto Valencia, Jeannie" sort="Soto Valencia, Jeannie" uniqKey="Soto Valencia J" first="Jeannie" last="Soto-Valencia">Jeannie Soto-Valencia</name></author><author><name sortKey="Johannes, Brooke" sort="Johannes, Brooke" uniqKey="Johannes B" first="Brooke" last="Johannes">Brooke Johannes</name></author><author><name sortKey="Ortega, Robert" sort="Ortega, Robert" uniqKey="Ortega R" first="Robert" last="Ortega">Robert Ortega</name></author><author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name></author><author><name sortKey="Cote, Lucien" sort="Cote, Lucien" uniqKey="Cote L" first="Lucien" last="Cote">Lucien Cote</name></author><author><name sortKey="Waters, Cheryl" sort="Waters, Cheryl" uniqKey="Waters C" first="Cheryl" last="Waters">Cheryl Waters</name></author><author><name sortKey="Mazzoni, Pietro" sort="Mazzoni, Pietro" uniqKey="Mazzoni P" first="Pietro" last="Mazzoni">Pietro Mazzoni</name></author><author><name sortKey="Ford, Blair" sort="Ford, Blair" uniqKey="Ford B" first="Blair" last="Ford">Blair Ford</name></author><author><name sortKey="Louis, Elan" sort="Louis, Elan" uniqKey="Louis E" first="Elan" last="Louis">Elan Louis</name></author><author><name sortKey="Levy, Oren" sort="Levy, Oren" uniqKey="Levy O" first="Oren" last="Levy">Oren Levy</name></author><author><name sortKey="Rosado, Llency" sort="Rosado, Llency" uniqKey="Rosado L" first="Llency" last="Rosado">Llency Rosado</name></author><author><name sortKey="Ruiz, Diana" sort="Ruiz, Diana" uniqKey="Ruiz D" first="Diana" last="Ruiz">Diana Ruiz</name></author><author><name sortKey="Dorovski, Tsvyatko" sort="Dorovski, Tsvyatko" uniqKey="Dorovski T" first="Tsvyatko" last="Dorovski">Tsvyatko Dorovski</name></author><author><name sortKey="Pauciulo, Michael" sort="Pauciulo, Michael" uniqKey="Pauciulo M" first="Michael" last="Pauciulo">Michael Pauciulo</name></author><author><name sortKey="Nichols, William" sort="Nichols, William" uniqKey="Nichols W" first="William" last="Nichols">William Nichols</name></author><author><name sortKey="Orr Urtreger, Avi" sort="Orr Urtreger, Avi" uniqKey="Orr Urtreger A" first="Avi" last="Orr-Urtreger">Avi Orr-Urtreger</name></author><author><name sortKey="Ozelius, Laurie" sort="Ozelius, Laurie" uniqKey="Ozelius L" first="Laurie" last="Ozelius">Laurie Ozelius</name></author><author><name sortKey="Clark, Lorraine" sort="Clark, Lorraine" uniqKey="Clark L" first="Lorraine" last="Clark">Lorraine Clark</name></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name></author><author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name></author><author><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S" last="Marder">Karen S. Marder</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Female</term><term>Genotype</term><term>Glycine (genetics)</term><term>Humans</term><term>Jews (genetics)</term><term>Male</term><term>Middle Aged</term><term>Mutation (genetics)</term><term>Parkinson Disease (ethnology)</term><term>Parkinson Disease (genetics)</term><term>Phenotype</term><term>Protein-Serine-Threonine Kinases (genetics)</term><term>Questionnaires</term><term>Regression Analysis</term><term>Serine (genetics)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glycine</term><term>Protein-Serine-Threonine Kinases</term><term>Serine</term></keywords><keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Jews</term><term>Mutation</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Phenotype</term><term>Questionnaires</term><term>Regression Analysis</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The phenotype of Parkinson's disease (PD) in patients with and without leucine-rich repeat kinase 2 (LRRK2) G2019S mutations reportedly is similar; however, large, uniformly evaluated series are lacking. The objective of this study was to characterize the clinical phenotype of Ashkenazi Jewish (AJ) PD carriers of the LRRK2 G2019S mutation. We studied 553 AJ PD patients, including 65 patients who were previously reported, from three sites (two in New York and one in Tel-Aviv). Glucocerebrosidase (GBA) mutation carriers were excluded. Evaluations included the Montreal Cognitive Assessment (MoCA), the Unified Parkinson's Disease Rating Scale (UPDRS), the Geriatric Depression Scale (GDS) and the Non-Motor Symptoms (NMS) questionnaire. Regression models were constructed to test the association between clinical and demographic features and LRRK2 status (outcome) in 488 newly recruited participants. LRRK2 G2019S carriers (n = 97) and non-carriers (n = 391) were similar in age and age at onset of PD. Carriers had longer disease duration (8.6 years vs. 6.1 years; P < 0.001), were more likely to be women (51.5% vs. 37.9%; P = 0.015), and more often reported first symptoms in the lower extremities (40.0% vs. 19.2%; P < 0.001). In logistic models that were adjusted for age, disease duration, sex, education, and site, carriers were more likely to have lower extremity onset (P < 0.001), postural instability and gait difficulty (PIGD) (P = 0.043), and a persistent levodopa response for >5 years (P = 0.042). Performance on the UPDRS, MoCA, GDS, and NMS did not differ by mutation status. PD in AJ LRRK2 G2019S mutation carriers is similar to idiopathic PD but is characterized by more frequent lower extremity involvement at onset and PIGD without the associated cognitive impairment.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24243757</PMID><DateCreated><Year>2013</Year><Month>12</Month><Day>10</Day></DateCreated><DateCompleted><Year>2014</Year><Month>07</Month><Day>29</Day></DateCompleted><DateRevised><Year>2014</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>14</Issue><PubDate><Year>2013</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations.</ArticleTitle><Pagination><MedlinePgn>1966-71</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25647</ELocationID><Abstract><AbstractText>The phenotype of Parkinson's disease (PD) in patients with and without leucine-rich repeat kinase 2 (LRRK2) G2019S mutations reportedly is similar; however, large, uniformly evaluated series are lacking. The objective of this study was to characterize the clinical phenotype of Ashkenazi Jewish (AJ) PD carriers of the LRRK2 G2019S mutation. We studied 553 AJ PD patients, including 65 patients who were previously reported, from three sites (two in New York and one in Tel-Aviv). Glucocerebrosidase (GBA) mutation carriers were excluded. Evaluations included the Montreal Cognitive Assessment (MoCA), the Unified Parkinson's Disease Rating Scale (UPDRS), the Geriatric Depression Scale (GDS) and the Non-Motor Symptoms (NMS) questionnaire. Regression models were constructed to test the association between clinical and demographic features and LRRK2 status (outcome) in 488 newly recruited participants. LRRK2 G2019S carriers (n = 97) and non-carriers (n = 391) were similar in age and age at onset of PD. Carriers had longer disease duration (8.6 years vs. 6.1 years; P < 0.001), were more likely to be women (51.5% vs. 37.9%; P = 0.015), and more often reported first symptoms in the lower extremities (40.0% vs. 19.2%; P < 0.001). In logistic models that were adjusted for age, disease duration, sex, education, and site, carriers were more likely to have lower extremity onset (P < 0.001), postural instability and gait difficulty (PIGD) (P = 0.043), and a persistent levodopa response for >5 years (P = 0.042). Performance on the UPDRS, MoCA, GDS, and NMS did not differ by mutation status. PD in AJ LRRK2 G2019S mutation carriers is similar to idiopathic PD but is characterized by more frequent lower extremity involvement at onset and PIGD without the associated cognitive impairment.</AbstractText><CopyrightInformation>© 2013 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Alcalay</LastName><ForeName>Roy N</ForeName><Initials>RN</Initials><AffiliationInfo><Affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mirelman</LastName><ForeName>Anat</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Saunders-Pullman</LastName><ForeName>Rachel</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Ming-X</ForeName><Initials>MX</Initials></Author><Author ValidYN="Y"><LastName>Mejia Santana</LastName><ForeName>Helen</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Raymond</LastName><ForeName>Deborah</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Roos</LastName><ForeName>Ernest</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Orbe-Reilly</LastName><ForeName>Martha</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Gurevich</LastName><ForeName>Tanya</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Bar Shira</LastName><ForeName>Anat</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Gana Weisz</LastName><ForeName>Mali</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Yasinovsky</LastName><ForeName>Kira</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Zalis</LastName><ForeName>Maayan</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Thaler</LastName><ForeName>Avner</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Deik</LastName><ForeName>Andres</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Barrett</LastName><ForeName>Matthew James</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Cabassa</LastName><ForeName>Jose</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Groves</LastName><ForeName>Mark</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hunt</LastName><ForeName>Ann L</ForeName><Initials>AL</Initials></Author><Author ValidYN="Y"><LastName>Lubarr</LastName><ForeName>Naomi</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>San Luciano</LastName><ForeName>Marta</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Miravite</LastName><ForeName>Joan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Palmese</LastName><ForeName>Christina</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Sachdev</LastName><ForeName>Rivka</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Sarva</LastName><ForeName>Harini</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Severt</LastName><ForeName>Lawrence</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Shanker</LastName><ForeName>Vicki</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Swan</LastName><ForeName>Matthew Carrington</ForeName><Initials>MC</Initials></Author><Author ValidYN="Y"><LastName>Soto-Valencia</LastName><ForeName>Jeannie</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Johannes</LastName><ForeName>Brooke</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Ortega</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Fahn</LastName><ForeName>Stanley</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Cote</LastName><ForeName>Lucien</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Waters</LastName><ForeName>Cheryl</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Mazzoni</LastName><ForeName>Pietro</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Ford</LastName><ForeName>Blair</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Louis</LastName><ForeName>Elan</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Levy</LastName><ForeName>Oren</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Rosado</LastName><ForeName>Llency</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Ruiz</LastName><ForeName>Diana</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Dorovski</LastName><ForeName>Tsvyatko</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Pauciulo</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Nichols</LastName><ForeName>William</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Orr-Urtreger</LastName><ForeName>Avi</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Ozelius</LastName><ForeName>Laurie</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>Lorraine</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Giladi</LastName><ForeName>Nir</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Bressman</LastName><ForeName>Susan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Marder</LastName><ForeName>Karen S</ForeName><Initials>KS</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>10628097</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K02 NS073836</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K02 NS080915</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K02NS080915</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NS050487</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NS060113</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS036630</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS060113</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 NS050487</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R56NS036630</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 RR024156</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 RR024156</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR000040</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>10</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>452VLY9402</RegistryNumber><NameOfSubstance UI="D012694">Serine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="C495280">LRRK2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>TE7660XO1C</RegistryNumber><NameOfSubstance 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Dec;28(14):1912-4</RefSource><PMID Version="1">24307480</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005838">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005998">Glycine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007585">Jews</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009154">Mutation</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000208">ethnology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010641">Phenotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017346">Protein-Serine-Threonine Kinases</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011795">Questionnaires</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012044">Regression Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012694">Serine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS516685</OtherID><OtherID Source="NLM">PMC3859844</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">LRRK2</Keyword><Keyword MajorTopicYN="N">Parkinson</Keyword><Keyword MajorTopicYN="N">genetics</Keyword><Keyword MajorTopicYN="N">postural instability and gait difficulty</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>5</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>7</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>7</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>11</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>11</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24243757</ArticleId><ArticleId IdType="doi">10.1002/mds.25647</ArticleId><ArticleId IdType="pmc">PMC3859844</ArticleId><ArticleId IdType="mid">NIHMS516685</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><noCountry><name sortKey="Bar Shira, Anat" sort="Bar Shira, Anat" uniqKey="Bar Shira A" first="Anat" last="Bar Shira">Anat Bar Shira</name><name sortKey="Barrett, Matthew James" sort="Barrett, Matthew James" uniqKey="Barrett M" first="Matthew James" last="Barrett">Matthew James Barrett</name><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name><name sortKey="Cabassa, Jose" sort="Cabassa, Jose" uniqKey="Cabassa J" first="Jose" last="Cabassa">Jose Cabassa</name><name sortKey="Clark, Lorraine" sort="Clark, Lorraine" uniqKey="Clark L" first="Lorraine" last="Clark">Lorraine Clark</name><name sortKey="Cote, Lucien" sort="Cote, Lucien" uniqKey="Cote L" first="Lucien" last="Cote">Lucien Cote</name><name sortKey="Deik, Andres" sort="Deik, Andres" uniqKey="Deik A" first="Andres" last="Deik">Andres Deik</name><name sortKey="Dorovski, Tsvyatko" sort="Dorovski, Tsvyatko" uniqKey="Dorovski T" first="Tsvyatko" last="Dorovski">Tsvyatko Dorovski</name><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name><name sortKey="Ford, Blair" sort="Ford, Blair" uniqKey="Ford B" first="Blair" last="Ford">Blair Ford</name><name sortKey="Gana Weisz, Mali" sort="Gana Weisz, Mali" uniqKey="Gana Weisz M" first="Mali" last="Gana Weisz">Mali Gana Weisz</name><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><name sortKey="Groves, Mark" sort="Groves, Mark" uniqKey="Groves M" first="Mark" last="Groves">Mark Groves</name><name sortKey="Gurevich, Tanya" sort="Gurevich, Tanya" uniqKey="Gurevich T" first="Tanya" last="Gurevich">Tanya Gurevich</name><name sortKey="Hunt, Ann L" sort="Hunt, Ann L" uniqKey="Hunt A" first="Ann L" last="Hunt">Ann L. Hunt</name><name sortKey="Johannes, Brooke" sort="Johannes, Brooke" uniqKey="Johannes B" first="Brooke" last="Johannes">Brooke Johannes</name><name sortKey="Levy, Oren" sort="Levy, Oren" uniqKey="Levy O" first="Oren" last="Levy">Oren Levy</name><name sortKey="Louis, Elan" sort="Louis, Elan" uniqKey="Louis E" first="Elan" last="Louis">Elan Louis</name><name sortKey="Lubarr, Naomi" sort="Lubarr, Naomi" uniqKey="Lubarr N" first="Naomi" last="Lubarr">Naomi Lubarr</name><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S" last="Marder">Karen S. Marder</name><name sortKey="Mazzoni, Pietro" sort="Mazzoni, Pietro" uniqKey="Mazzoni P" first="Pietro" last="Mazzoni">Pietro Mazzoni</name><name sortKey="Mejia Santana, Helen" sort="Mejia Santana, Helen" uniqKey="Mejia Santana H" first="Helen" last="Mejia Santana">Helen Mejia Santana</name><name sortKey="Miravite, Joan" sort="Miravite, Joan" uniqKey="Miravite J" first="Joan" last="Miravite">Joan Miravite</name><name sortKey="Mirelman, Anat" sort="Mirelman, Anat" uniqKey="Mirelman A" first="Anat" last="Mirelman">Anat Mirelman</name><name sortKey="Nichols, William" sort="Nichols, William" uniqKey="Nichols W" first="William" last="Nichols">William Nichols</name><name sortKey="Orbe Reilly, Martha" sort="Orbe Reilly, Martha" uniqKey="Orbe Reilly M" first="Martha" last="Orbe-Reilly">Martha Orbe-Reilly</name><name sortKey="Orr Urtreger, Avi" sort="Orr Urtreger, Avi" uniqKey="Orr Urtreger A" first="Avi" last="Orr-Urtreger">Avi Orr-Urtreger</name><name sortKey="Ortega, Robert" sort="Ortega, Robert" uniqKey="Ortega R" first="Robert" last="Ortega">Robert Ortega</name><name sortKey="Ozelius, Laurie" sort="Ozelius, Laurie" uniqKey="Ozelius L" first="Laurie" last="Ozelius">Laurie Ozelius</name><name sortKey="Palmese, Christina" sort="Palmese, Christina" uniqKey="Palmese C" first="Christina" last="Palmese">Christina Palmese</name><name sortKey="Pauciulo, Michael" sort="Pauciulo, Michael" uniqKey="Pauciulo M" first="Michael" last="Pauciulo">Michael Pauciulo</name><name sortKey="Raymond, Deborah" sort="Raymond, Deborah" uniqKey="Raymond D" first="Deborah" last="Raymond">Deborah Raymond</name><name sortKey="Roos, Ernest" sort="Roos, Ernest" uniqKey="Roos E" first="Ernest" last="Roos">Ernest Roos</name><name sortKey="Rosado, Llency" sort="Rosado, Llency" uniqKey="Rosado L" first="Llency" last="Rosado">Llency Rosado</name><name sortKey="Ruiz, Diana" sort="Ruiz, Diana" uniqKey="Ruiz D" first="Diana" last="Ruiz">Diana Ruiz</name><name sortKey="Sachdev, Rivka" sort="Sachdev, Rivka" uniqKey="Sachdev R" first="Rivka" last="Sachdev">Rivka Sachdev</name><name sortKey="San Luciano, Marta" sort="San Luciano, Marta" uniqKey="San Luciano M" first="Marta" last="San Luciano">Marta San Luciano</name><name sortKey="Sarva, Harini" sort="Sarva, Harini" uniqKey="Sarva H" first="Harini" last="Sarva">Harini Sarva</name><name sortKey="Saunders Pullman, Rachel" sort="Saunders Pullman, Rachel" uniqKey="Saunders Pullman R" first="Rachel" last="Saunders-Pullman">Rachel Saunders-Pullman</name><name sortKey="Severt, Lawrence" sort="Severt, Lawrence" uniqKey="Severt L" first="Lawrence" last="Severt">Lawrence Severt</name><name sortKey="Shanker, Vicki" sort="Shanker, Vicki" uniqKey="Shanker V" first="Vicki" last="Shanker">Vicki Shanker</name><name sortKey="Soto Valencia, Jeannie" sort="Soto Valencia, Jeannie" uniqKey="Soto Valencia J" first="Jeannie" last="Soto-Valencia">Jeannie Soto-Valencia</name><name sortKey="Swan, Matthew Carrington" sort="Swan, Matthew Carrington" uniqKey="Swan M" first="Matthew Carrington" last="Swan">Matthew Carrington Swan</name><name sortKey="Tang, Ming X" sort="Tang, Ming X" uniqKey="Tang M" first="Ming-X" last="Tang">Ming-X Tang</name><name sortKey="Thaler, Avner" sort="Thaler, Avner" uniqKey="Thaler A" first="Avner" last="Thaler">Avner Thaler</name><name sortKey="Waters, Cheryl" sort="Waters, Cheryl" uniqKey="Waters C" first="Cheryl" last="Waters">Cheryl Waters</name><name sortKey="Yasinovsky, Kira" sort="Yasinovsky, Kira" uniqKey="Yasinovsky K" first="Kira" last="Yasinovsky">Kira Yasinovsky</name><name sortKey="Zalis, Maayan" sort="Zalis, Maayan" uniqKey="Zalis M" first="Maayan" last="Zalis">Maayan Zalis</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N" last="Alcalay">Roy N. Alcalay</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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