Primary progressive aphasia with parkinsonism.
Identifieur interne : 000845 ( PubMed/Checkpoint ); précédent : 000844; suivant : 000846Primary progressive aphasia with parkinsonism.
Auteurs : Karen M. Doherty [Royaume-Uni] ; Jonathan D. Rohrer ; Andrew J. Lees ; Janice L. Holton ; Jason WarrenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Amyloid beta-Peptides (metabolism), Aphasia, Primary Progressive (etiology), Brain (pathology), Gait Disorders, Neurologic (etiology), Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mental Status Schedule, Parkinsonian Disorders (complications), Parkinsonian Disorders (pathology), Writing, alpha-Synuclein (metabolism), tau Proteins (metabolism).
- MESH :
- chemical , metabolism : Amyloid beta-Peptides, alpha-Synuclein, tau Proteins.
- complications : Parkinsonian Disorders.
- etiology : Aphasia, Primary Progressive, Gait Disorders, Neurologic.
- pathology : Brain, Parkinsonian Disorders.
- Aged, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mental Status Schedule, Writing.
Abstract
A 65-year-old man presented with word-finding difficulty and gait disturbance. His speech was nonfluent with word retrieval impairment and difficulties with sentence repetition. Other cognitive domains were intact initially. He developed asymmetrical bradykinesia, rigidity and a rest tremor. Over the following 8 years, his speech production impairment slowly deteriorated with the development of a motor speech disorder, anomia, impaired repetition of single words as well as sentences, and impaired comprehension of initially sentences then single words. His parkinsonian syndrome also deteriorated with limited response to levodopa. Serial brain MRI revealed progressive asymmetric perisylvian atrophy. He died after a disease duration of 12 years. The clinical syndrome is discussed by an expert, the pathology is described, and important clinical points from the case are highlighted.
DOI: 10.1002/mds.25341
PubMed: 23401267
Affiliations:
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Doherty</name><affiliation wicri:level="3"><nlm:affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rohrer, Jonathan D" sort="Rohrer, Jonathan D" uniqKey="Rohrer J" first="Jonathan D" last="Rohrer">Jonathan D. Rohrer</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name></author><author><name sortKey="Holton, Janice L" sort="Holton, Janice L" uniqKey="Holton J" first="Janice L" last="Holton">Janice L. Holton</name></author><author><name sortKey="Warren, Jason" sort="Warren, Jason" uniqKey="Warren J" first="Jason" last="Warren">Jason Warren</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Amyloid beta-Peptides (metabolism)</term><term>Aphasia, Primary Progressive (etiology)</term><term>Brain (pathology)</term><term>Gait Disorders, Neurologic (etiology)</term><term>Humans</term><term>Longitudinal Studies</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mental Status Schedule</term><term>Parkinsonian Disorders (complications)</term><term>Parkinsonian Disorders (pathology)</term><term>Writing</term><term>alpha-Synuclein (metabolism)</term><term>tau Proteins (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amyloid beta-Peptides</term><term>alpha-Synuclein</term><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Aphasia, Primary Progressive</term><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Longitudinal Studies</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mental Status Schedule</term><term>Writing</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A 65-year-old man presented with word-finding difficulty and gait disturbance. His speech was nonfluent with word retrieval impairment and difficulties with sentence repetition. Other cognitive domains were intact initially. He developed asymmetrical bradykinesia, rigidity and a rest tremor. Over the following 8 years, his speech production impairment slowly deteriorated with the development of a motor speech disorder, anomia, impaired repetition of single words as well as sentences, and impaired comprehension of initially sentences then single words. His parkinsonian syndrome also deteriorated with limited response to levodopa. Serial brain MRI revealed progressive asymmetric perisylvian atrophy. He died after a disease duration of 12 years. The clinical syndrome is discussed by an expert, the pathology is described, and important clinical points from the case are highlighted.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23401267</PMID><DateCreated><Year>2013</Year><Month>06</Month><Day>26</Day></DateCreated><DateCompleted><Year>2014</Year><Month>01</Month><Day>30</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>6</Issue><PubDate><Year>2013</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Primary progressive aphasia with parkinsonism.</ArticleTitle><Pagination><MedlinePgn>741-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25341</ELocationID><Abstract><AbstractText>A 65-year-old man presented with word-finding difficulty and gait disturbance. His speech was nonfluent with word retrieval impairment and difficulties with sentence repetition. Other cognitive domains were intact initially. He developed asymmetrical bradykinesia, rigidity and a rest tremor. Over the following 8 years, his speech production impairment slowly deteriorated with the development of a motor speech disorder, anomia, impaired repetition of single words as well as sentences, and impaired comprehension of initially sentences then single words. His parkinsonian syndrome also deteriorated with limited response to levodopa. Serial brain MRI revealed progressive asymmetric perisylvian atrophy. He died after a disease duration of 12 years. The clinical syndrome is discussed by an expert, the pathology is described, and important clinical points from the case are highlighted.</AbstractText><CopyrightInformation>Copyright © 2013 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Doherty</LastName><ForeName>Karen M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rohrer</LastName><ForeName>Jonathan D</ForeName><Initials>JD</Initials></Author><Author ValidYN="Y"><LastName>Lees</LastName><ForeName>Andrew J</ForeName><Initials>AJ</Initials></Author><Author ValidYN="Y"><LastName>Holton</LastName><ForeName>Janice L</ForeName><Initials>JL</Initials></Author><Author 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beta-Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051844">alpha-Synuclein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016875">tau Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2003 Mar-Apr;24(2):197-211</RefSource><PMID Version="1">12498954</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2002 Jun 25;58(12):1791-800</RefSource><PMID Version="1">12084879</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 1991;6(4):342-6</RefSource><PMID Version="1">1758453</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2005 Dec 27;65(12):1863-72</RefSource><PMID Version="1">16237129</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2007 Jul;130(Pt 7):1787-98</RefSource><PMID Version="1">17535834</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cortex. 2007 Oct;43(7):835-45</RefSource><PMID Version="1">17941342</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cortex. 2009 Sep;45(8):912-4</RefSource><PMID Version="1">19447385</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2010 Jul;133(Pt 7):2045-57</RefSource><PMID Version="1">20584946</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Alzheimers Dis Other Demen. 2011 Feb;26(1):72-7</RefSource><PMID Version="1">21282281</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2011 Mar 15;76(11):1006-14</RefSource><PMID Version="1">21325651</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Alzheimer Res. 2011 May;8(3):266-72</RefSource><PMID Version="1">21222598</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2011 Sep;134(Pt 9):2565-81</RefSource><PMID Version="1">21908872</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Neuropathol. 2012 Jan;123(1):1-11</RefSource><PMID Version="1">22101365</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2012 Apr;33(4):744-52</RefSource><PMID Version="1">20580129</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2004 Mar;55(3):335-46</RefSource><PMID Version="1">14991811</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016229">Amyloid beta-Peptides</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName 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Holton</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name><name sortKey="Rohrer, Jonathan D" sort="Rohrer, Jonathan D" uniqKey="Rohrer J" first="Jonathan D" last="Rohrer">Jonathan D. Rohrer</name><name sortKey="Warren, Jason" sort="Warren, Jason" uniqKey="Warren J" first="Jason" last="Warren">Jason Warren</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Doherty, Karen M" sort="Doherty, Karen M" uniqKey="Doherty K" first="Karen M" last="Doherty">Karen M. Doherty</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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