Abnormal dorsal premotor-motor inhibition in writer's cramp.
Identifieur interne : 000696 ( PubMed/Checkpoint ); précédent : 000695; suivant : 000697Abnormal dorsal premotor-motor inhibition in writer's cramp.
Auteurs : Sarah Pirio Richardson [États-Unis] ; Sandra Beck ; Barbara Bliem ; Mark HallettSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Analysis of Variance, Case-Control Studies, Choice Behavior, Dystonic Disorders (pathology), Electromyography, Evoked Potentials, Motor (physiology), Female, Functional Laterality, H-Reflex (physiology), Humans, Inhibition (Psychology), Male, Motor Cortex (physiopathology), Neural Inhibition (physiology), Reaction Time, Spinal Cord (physiopathology), Transcranial Magnetic Stimulation.
- MESH :
- pathology : Dystonic Disorders.
- physiology : Evoked Potentials, Motor, H-Reflex, Neural Inhibition.
- physiopathology : Motor Cortex, Spinal Cord.
- Analysis of Variance, Case-Control Studies, Choice Behavior, Electromyography, Female, Functional Laterality, Humans, Inhibition (Psychology), Male, Reaction Time, Transcranial Magnetic Stimulation.
Abstract
The authors hypothesized that a deficient premotor-motor inhibitory network contributes to the unwanted involuntary movements in dystonia. The authors studied nine controls and nine patients with writer's cramp (WC). Dorsal premotor-motor cortical inhibition (dPMI) was tested by applying conditioning transcranial magnetic stimulation (TMS) to the dorsal premotor cortex and then a test pulse to the ipsilateral motor cortex at an interval of 6 ms. The authors used an H-reflex in flexor carpi radialis paired with TMS over the premotor cortex to assess for spinal cord excitability change. Finally, the authors interrupted a choice reaction time task with TMS over dorsal premotor cortex to assess performance in a nondystonic task. The results showed that WC patients exhibited dPMI at rest (88.5%, the ratio of conditioned to unconditioned test pulse), in contrast to controls, who did not show dPMI (109.6%) (P = 0.0198). This difference between patients and controls persisted during contraction (100% vs. 112%) and pen-holding (95.6% vs. 111%). The H-reflex in the arm was not modulated by the premotor cortex stimulation. The WC patients made more errors, and the error rate improved with TMS over the premotor cortex. These results suggest that abnormal premotor-motor interactions may play a role in the pathophysiology of focal dystonia. The dPMI was not modulated by task in either group, but was constantly greater in the patients. The significance of the increased inhibition is likely to be compensatory. It appears to be a robust finding and, in combination with other features, could be further explored as a biomarker.
DOI: 10.1002/mds.25878
PubMed: 24710852
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Abnormal dorsal premotor-motor inhibition in writer's cramp.</title><author><name sortKey="Pirio Richardson, Sarah" sort="Pirio Richardson, Sarah" uniqKey="Pirio Richardson S" first="Sarah" last="Pirio Richardson">Sarah Pirio Richardson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Beck, Sandra" sort="Beck, Sandra" uniqKey="Beck S" first="Sandra" last="Beck">Sandra Beck</name></author><author><name sortKey="Bliem, Barbara" sort="Bliem, Barbara" uniqKey="Bliem B" first="Barbara" last="Bliem">Barbara Bliem</name></author><author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24710852</idno><idno type="pmid">24710852</idno><idno type="doi">10.1002/mds.25878</idno><idno type="wicri:Area/PubMed/Corpus">000544</idno><idno type="wicri:Area/PubMed/Curation">000544</idno><idno type="wicri:Area/PubMed/Checkpoint">000696</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Abnormal dorsal premotor-motor inhibition in writer's cramp.</title><author><name sortKey="Pirio Richardson, Sarah" sort="Pirio Richardson, Sarah" uniqKey="Pirio Richardson S" first="Sarah" last="Pirio Richardson">Sarah Pirio Richardson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Beck, Sandra" sort="Beck, Sandra" uniqKey="Beck S" first="Sandra" last="Beck">Sandra Beck</name></author><author><name sortKey="Bliem, Barbara" sort="Bliem, Barbara" uniqKey="Bliem B" first="Barbara" last="Bliem">Barbara Bliem</name></author><author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Choice Behavior</term><term>Dystonic Disorders (pathology)</term><term>Electromyography</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Functional Laterality</term><term>H-Reflex (physiology)</term><term>Humans</term><term>Inhibition (Psychology)</term><term>Male</term><term>Motor Cortex (physiopathology)</term><term>Neural Inhibition (physiology)</term><term>Reaction Time</term><term>Spinal Cord (physiopathology)</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>H-Reflex</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Spinal Cord</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Choice Behavior</term><term>Electromyography</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Inhibition (Psychology)</term><term>Male</term><term>Reaction Time</term><term>Transcranial Magnetic Stimulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The authors hypothesized that a deficient premotor-motor inhibitory network contributes to the unwanted involuntary movements in dystonia. The authors studied nine controls and nine patients with writer's cramp (WC). Dorsal premotor-motor cortical inhibition (dPMI) was tested by applying conditioning transcranial magnetic stimulation (TMS) to the dorsal premotor cortex and then a test pulse to the ipsilateral motor cortex at an interval of 6 ms. The authors used an H-reflex in flexor carpi radialis paired with TMS over the premotor cortex to assess for spinal cord excitability change. Finally, the authors interrupted a choice reaction time task with TMS over dorsal premotor cortex to assess performance in a nondystonic task. The results showed that WC patients exhibited dPMI at rest (88.5%, the ratio of conditioned to unconditioned test pulse), in contrast to controls, who did not show dPMI (109.6%) (P = 0.0198). This difference between patients and controls persisted during contraction (100% vs. 112%) and pen-holding (95.6% vs. 111%). The H-reflex in the arm was not modulated by the premotor cortex stimulation. The WC patients made more errors, and the error rate improved with TMS over the premotor cortex. These results suggest that abnormal premotor-motor interactions may play a role in the pathophysiology of focal dystonia. The dPMI was not modulated by task in either group, but was constantly greater in the patients. The significance of the increased inhibition is likely to be compensatory. It appears to be a robust finding and, in combination with other features, could be further explored as a biomarker.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24710852</PMID><DateCreated><Year>2014</Year><Month>05</Month><Day>06</Day></DateCreated><DateCompleted><Year>2014</Year><Month>12</Month><Day>19</Day></DateCompleted><DateRevised><Year>2015</Year><Month>08</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>May</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Abnormal dorsal premotor-motor inhibition in writer's cramp.</ArticleTitle><Pagination><MedlinePgn>797-803</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25878</ELocationID><Abstract><AbstractText>The authors hypothesized that a deficient premotor-motor inhibitory network contributes to the unwanted involuntary movements in dystonia. The authors studied nine controls and nine patients with writer's cramp (WC). Dorsal premotor-motor cortical inhibition (dPMI) was tested by applying conditioning transcranial magnetic stimulation (TMS) to the dorsal premotor cortex and then a test pulse to the ipsilateral motor cortex at an interval of 6 ms. The authors used an H-reflex in flexor carpi radialis paired with TMS over the premotor cortex to assess for spinal cord excitability change. Finally, the authors interrupted a choice reaction time task with TMS over dorsal premotor cortex to assess performance in a nondystonic task. The results showed that WC patients exhibited dPMI at rest (88.5%, the ratio of conditioned to unconditioned test pulse), in contrast to controls, who did not show dPMI (109.6%) (P = 0.0198). This difference between patients and controls persisted during contraction (100% vs. 112%) and pen-holding (95.6% vs. 111%). The H-reflex in the arm was not modulated by the premotor cortex stimulation. The WC patients made more errors, and the error rate improved with TMS over the premotor cortex. These results suggest that abnormal premotor-motor interactions may play a role in the pathophysiology of focal dystonia. The dPMI was not modulated by task in either group, but was constantly greater in the patients. The significance of the increased inhibition is likely to be compensatory. It appears to be a robust finding and, in combination with other features, could be further explored as a biomarker.</AbstractText><CopyrightInformation>© 2014 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pirio Richardson</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beck</LastName><ForeName>Sandra</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Bliem</LastName><ForeName>Barbara</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Hallett</LastName><ForeName>Mark</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>KL2 TR000089</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>KL2 TR000089</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR000041</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR000041</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>04</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(10):e47574</RefSource><PMID Version="1">23071824</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Brain Mapp. 2013 Mar;34(3):613-25</RefSource><PMID Version="1">22113948</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Brain Res. 2013 Mar;225(1):85-92</RefSource><PMID Version="1">23192337</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2013 Feb;136(Pt 2):444-54</RefSource><PMID 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RefType="Cites"><RefSource>Neurobiol Dis. 2011 May;42(2):177-84</RefSource><PMID Version="1">20817092</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 1999 Sep 15;19(18):8043-8</RefSource><PMID Version="1">10479704</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000704">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016022">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002755">Choice Behavior</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020821">Dystonic Disorders</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004576">Electromyography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019054">Evoked Potentials, Motor</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007839">Functional Laterality</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006181">H-Reflex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D007266">Inhibition (Psychology)</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009044">Motor Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009433">Neural Inhibition</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013116">Spinal Cord</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D050781">Transcranial Magnetic Stimulation</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS592294</OtherID><OtherID Source="NLM">PMC4122418</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">TMS</Keyword><Keyword MajorTopicYN="N">dystonia</Keyword><Keyword MajorTopicYN="N">motor cortex</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>10</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>1</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>2</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>4</Month><Day>7</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>12</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24710852</ArticleId><ArticleId IdType="doi">10.1002/mds.25878</ArticleId><ArticleId IdType="pmc">PMC4122418</ArticleId><ArticleId IdType="mid">NIHMS592294</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Beck, Sandra" sort="Beck, Sandra" uniqKey="Beck S" first="Sandra" last="Beck">Sandra Beck</name><name sortKey="Bliem, Barbara" sort="Bliem, Barbara" uniqKey="Bliem B" first="Barbara" last="Bliem">Barbara Bliem</name><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Pirio Richardson, Sarah" sort="Pirio Richardson, Sarah" uniqKey="Pirio Richardson S" first="Sarah" last="Pirio Richardson">Sarah Pirio Richardson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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