MovDisordV3, PubMed, Checkpoint, bibRecord, 000651

Cognitive deficits in Parkinson's disease: a cognitive neuroscience perspective.

Identifieur interne : 000651 ( PubMed/Checkpoint ); précédent : 000650; suivant : 000652

Cognitive deficits in Parkinson's disease: a cognitive neuroscience perspective.

Auteurs : Trevor W. Robbins [Royaume-Uni] ; Roshan Cools

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.

RBID : pubmed:24757109

English descriptors

KwdEn :
- Animals, Cognition (physiology), Cognition Disorders (etiology), Cognition Disorders (physiopathology), Dementia (etiology), Dementia (physiopathology), Humans, Memory (physiology), Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology).
MESH :
- complications : Parkinson Disease.
- diagnosis : Parkinson Disease.
- etiology : Cognition Disorders, Dementia.
- physiology : Cognition, Memory.
- physiopathology : Cognition Disorders, Dementia, Parkinson Disease.
- Animals, Humans.

Abstract

Progress in characterization of the nature, neural basis, and treatment of cognitive deficits in Parkinson's disease is reviewed from the perspective of cognitive neuroscience. An initial emphasis on fronto-striatal executive deficits is surveyed along with the discoveries of disruption as well as remediation of certain impairments by dopaminergic mediation and their association with theories of reinforcement learning. Subsequent focus on large cohorts has revealed considerable heterogeneity in the cognitive impairments as well as a suggestion of at least two distinct syndromes, with the dopamine-dependent fronto-striatal deficits being somewhat independent of other signs commonly associated with Parkinson's disease dementia. The utility is proposed of a new, integrated cognitive neuroscience approach based on combining genetic and neuroimaging methodologies with neuropsychological and, ultimately, psychopharmacological approaches.

DOI: 10.1002/mds.25853
PubMed: 24757109

Affiliations:

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pubmed:24757109

Le document en format XML

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<term>Dementia (etiology)</term>
<term>Dementia (physiopathology)</term>
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<front><div type="abstract" xml:lang="en">Progress in characterization of the nature, neural basis, and treatment of cognitive deficits in Parkinson's disease is reviewed from the perspective of cognitive neuroscience. An initial emphasis on fronto-striatal executive deficits is surveyed along with the discoveries of disruption as well as remediation of certain impairments by dopaminergic mediation and their association with theories of reinforcement learning. Subsequent focus on large cohorts has revealed considerable heterogeneity in the cognitive impairments as well as a suggestion of at least two distinct syndromes, with the dopamine-dependent fronto-striatal deficits being somewhat independent of other signs commonly associated with Parkinson's disease dementia. The utility is proposed of a new, integrated cognitive neuroscience approach based on combining genetic and neuroimaging methodologies with neuropsychological and, ultimately, psychopharmacological approaches.</div>
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<DateCompleted><Year>2014</Year>
<Month>12</Month>
<Day>19</Day>
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<DateRevised><Year>2015</Year>
<Month>07</Month>
<Day>08</Day>
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<JournalIssue CitedMedium="Internet"><Volume>29</Volume>
<Issue>5</Issue>
<PubDate><Year>2014</Year>
<Month>Apr</Month>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<CopyrightInformation>© 2014 International Parkinson and Movement Disorder Society.</CopyrightInformation>
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<Keyword MajorTopicYN="N">prefrontal cortex</Keyword>
<Keyword MajorTopicYN="N">striatum</Keyword>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Robbins, Trevor W" sort="Robbins, Trevor W" uniqKey="Robbins T" first="Trevor W" last="Robbins">Trevor W. Robbins</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Cognitive deficits in Parkinson's disease: a cognitive neuroscience perspective.

Cognitive deficits in Parkinson's disease: a cognitive neuroscience perspective.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki