Movement Disorders (revue)

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In vivo dopaminergic and serotonergic dysfunction in DCTN1 gene mutation carriers.

Identifieur interne : 000557 ( PubMed/Checkpoint ); précédent : 000556; suivant : 000558

In vivo dopaminergic and serotonergic dysfunction in DCTN1 gene mutation carriers.

Auteurs : Andre C. Felicio [Canada] ; Katherine Dinelle ; Pankaj A. Agarwal ; Jessamyn Mckenzie ; Nicole Heffernan ; Jeremy D. Road ; Silke Appel-Cresswell ; Zbigniew K. Wszolek ; Matthew J. Farrer ; Michael Schulzer ; Vesna Sossi ; A Jon Stoessl

Source :

RBID : pubmed:24797316

English descriptors

Abstract

We used positron emission tomography (PET) to assess dopaminergic and serotonergic terminal density in three subjects carrying a mutation in the DCT1 gene, two clinically affected with Perry syndrome.

DOI: 10.1002/mds.25893
PubMed: 24797316


Affiliations:


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pubmed:24797316

Le document en format XML

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<div type="abstract" xml:lang="en">We used positron emission tomography (PET) to assess dopaminergic and serotonergic terminal density in three subjects carrying a mutation in the DCT1 gene, two clinically affected with Perry syndrome.</div>
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<AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">We used positron emission tomography (PET) to assess dopaminergic and serotonergic terminal density in three subjects carrying a mutation in the DCT1 gene, two clinically affected with Perry syndrome.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">All subjects had brain imaging using 18F-6-fluoro-l-dopa (FDOPA, dopamine synthesis and storage), (+)-11C-dihydrotetrabenazine (DTBZ, vesicular monoamine transporter type 2), and 11C-raclopride (RAC, dopamine D2/D3 receptors). One subject also underwent PET with 11C-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB, serotonin transporter).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">FDOPA-PET and DTBZ-PET in the affected individuals showed a reduction of striatal tracer uptake. Also, RAC-PET showed higher uptake in these area. DASB-PET showed significant uptake changes in left orbitofrontal cortex, bilateral anterior insula, left dorsolateral prefrontal cortex, left orbitofrontal cortex, left posterior cingulate cortex, left caudate, and left ventral striatum.</AbstractText>
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