Antisaccades and executive dysfunction in early drug-naive Parkinson's disease: The discovery study.
Identifieur interne : 000321 ( PubMed/Checkpoint ); précédent : 000320; suivant : 000322Antisaccades and executive dysfunction in early drug-naive Parkinson's disease: The discovery study.
Auteurs : Chrystalina A. Antoniades [Royaume-Uni] ; Nele Demeyere [Royaume-Uni] ; Christopher Kennard [Royaume-Uni] ; Glyn W. Humphreys [Royaume-Uni] ; Michele T. Hu [Royaume-Uni]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Cognitive impairment is well recognized in Parkinson's disease (PD), but when it begins to develop is unclear. The aim of this study was to identify early signs of cognitive impairment along with abnormalities in saccadic behavior in newly diagnosed unmedicated PD patients.
DOI: 10.1002/mds.26134
PubMed: 25600361
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Antoniades</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Demeyere, Nele" sort="Demeyere, Nele" uniqKey="Demeyere N" first="Nele" last="Demeyere">Nele Demeyere</name><affiliation wicri:level="4"><nlm:affiliation>Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Kennard, Christopher" sort="Kennard, Christopher" uniqKey="Kennard C" first="Christopher" last="Kennard">Christopher Kennard</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Humphreys, Glyn W" sort="Humphreys, Glyn W" uniqKey="Humphreys G" first="Glyn W" last="Humphreys">Glyn W. 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Antoniades</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Demeyere, Nele" sort="Demeyere, Nele" uniqKey="Demeyere N" first="Nele" last="Demeyere">Nele Demeyere</name><affiliation wicri:level="4"><nlm:affiliation>Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Kennard, Christopher" sort="Kennard, Christopher" uniqKey="Kennard C" first="Christopher" last="Kennard">Christopher Kennard</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Humphreys, Glyn W" sort="Humphreys, Glyn W" uniqKey="Humphreys G" first="Glyn W" last="Humphreys">Glyn W. Humphreys</name><affiliation wicri:level="4"><nlm:affiliation>Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Hu, Michele T" sort="Hu, Michele T" uniqKey="Hu M" first="Michele T" last="Hu">Michele T. Hu</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cognitive impairment is well recognized in Parkinson's disease (PD), but when it begins to develop is unclear. The aim of this study was to identify early signs of cognitive impairment along with abnormalities in saccadic behavior in newly diagnosed unmedicated PD patients.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">25600361</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>20</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>May</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Antisaccades and executive dysfunction in early drug-naive Parkinson's disease: The discovery study.</ArticleTitle><Pagination><MedlinePgn>843-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26134</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Cognitive impairment is well recognized in Parkinson's disease (PD), but when it begins to develop is unclear. The aim of this study was to identify early signs of cognitive impairment along with abnormalities in saccadic behavior in newly diagnosed unmedicated PD patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Nineteen drug-naive PD patients and 20 controls were examined using a battery of tests, including an antisaccade task, phonemic and semantic verbal fluencies, and a switching and rule finding task.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">With simple tasks, no differences were found between the two groups. However, cognitive performance of the two groups diverged with more complex tasks, occurring independently of PD-related motor impairment. Patients exhibited higher antisaccadic error rates and switch costs in the task switching test, and performed significantly worse in the rule finding task.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Certain cognitive domains and saccadic parameters are already significantly impoverished in newly diagnosed Parkinson's patients, even before the initiation of medication.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Antoniades</LastName><ForeName>Chrystalina A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demeyere</LastName><ForeName>Nele</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kennard</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Humphreys</LastName><ForeName>Glyn W</ForeName><Initials>GW</Initials><AffiliationInfo><Affiliation>Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Michele T</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>01</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">antisaccades</Keyword><Keyword MajorTopicYN="N">executive function</Keyword><Keyword MajorTopicYN="N">eye movements</Keyword><Keyword MajorTopicYN="N">task switching</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>7</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>11</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>11</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>1</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>1</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>1</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>1</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25600361</ArticleId><ArticleId IdType="doi">10.1002/mds.26134</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Oxfordshire</li></region><settlement><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Antoniades, Chrystalina A" sort="Antoniades, Chrystalina A" uniqKey="Antoniades C" first="Chrystalina A" last="Antoniades">Chrystalina A. Antoniades</name></region><name sortKey="Demeyere, Nele" sort="Demeyere, Nele" uniqKey="Demeyere N" first="Nele" last="Demeyere">Nele Demeyere</name><name sortKey="Hu, Michele T" sort="Hu, Michele T" uniqKey="Hu M" first="Michele T" last="Hu">Michele T. Hu</name><name sortKey="Humphreys, Glyn W" sort="Humphreys, Glyn W" uniqKey="Humphreys G" first="Glyn W" last="Humphreys">Glyn W. Humphreys</name><name sortKey="Kennard, Christopher" sort="Kennard, Christopher" uniqKey="Kennard C" first="Christopher" last="Kennard">Christopher Kennard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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