Colonic bacterial composition in Parkinson's disease.
Identifieur interne : 000289 ( PubMed/Checkpoint ); précédent : 000288; suivant : 000290Colonic bacterial composition in Parkinson's disease.
Auteurs : Ali Keshavarzian [États-Unis] ; Stefan J. Green [États-Unis] ; Phillip A. Engen [États-Unis] ; Robin M. Voigt [États-Unis] ; Ankur Naqib [États-Unis] ; Christopher B. Forsyth [États-Unis] ; Ece Mutlu [États-Unis] ; Kathleen M. Shannon [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
We showed that Parkinson's disease (PD) patients have alpha-synuclein (α-Syn) aggregation in their colon with evidence of colonic inflammation. If PD patients have altered colonic microbiota, dysbiosis might be the mechanism of neuroinflammation that leads to α-Syn misfolding and PD pathology.
DOI: 10.1002/mds.26307
PubMed: 26179554
Affiliations:
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Green</name><affiliation wicri:level="2"><nlm:affiliation>DNA Services Facility, Research Resources Center, University of Illinois at Chicago, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>DNA Services Facility, Research Resources Center, University of Illinois at Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Engen, Phillip A" sort="Engen, Phillip A" uniqKey="Engen P" first="Phillip A" last="Engen">Phillip A. Engen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Voigt, Robin M" sort="Voigt, Robin M" uniqKey="Voigt R" first="Robin M" last="Voigt">Robin M. Voigt</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Naqib, Ankur" sort="Naqib, Ankur" uniqKey="Naqib A" first="Ankur" last="Naqib">Ankur Naqib</name><affiliation wicri:level="2"><nlm:affiliation>DNA Services Facility, Research Resources Center, University of Illinois at Chicago, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>DNA Services Facility, Research Resources Center, University of Illinois at Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Forsyth, Christopher B" sort="Forsyth, Christopher B" uniqKey="Forsyth C" first="Christopher B" last="Forsyth">Christopher B. Forsyth</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Mutlu, Ece" sort="Mutlu, Ece" uniqKey="Mutlu E" first="Ece" last="Mutlu">Ece Mutlu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We showed that Parkinson's disease (PD) patients have alpha-synuclein (α-Syn) aggregation in their colon with evidence of colonic inflammation. If PD patients have altered colonic microbiota, dysbiosis might be the mechanism of neuroinflammation that leads to α-Syn misfolding and PD pathology.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">26179554</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>03</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>10</Issue><PubDate><Year>2015</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Colonic bacterial composition in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1351-60</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26307</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">We showed that Parkinson's disease (PD) patients have alpha-synuclein (α-Syn) aggregation in their colon with evidence of colonic inflammation. If PD patients have altered colonic microbiota, dysbiosis might be the mechanism of neuroinflammation that leads to α-Syn misfolding and PD pathology.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Sixty-six sigmoid mucosal biopsies and 65 fecal samples were collected from 38 PD patients and 34 healthy controls. Mucosal-associated and feces microbiota compositions were characterized using high-throughput ribosomal RNA gene amplicon sequencing. Data were correlated with clinical measures of PD, and a predictive assessment of microbial community functional potential was used to identify microbial functions.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The mucosal and fecal microbial community of PD patients was significantly different than control subjects, with the fecal samples showing more marked differences than the sigmoid mucosa. At the taxonomic level of genus, putative, "anti-inflammatory" butyrate-producing bacteria from the genera Blautia, Coprococcus, and Roseburia were significantly more abundant in feces of controls than PD patients. Bacteria from the genus Faecalibacterium were significantly more abundant in the mucosa of controls than PD. Putative, "proinflammatory" Proteobacteria of the genus Ralstonia were significantly more abundant in mucosa of PD than controls. Predictive metagenomics indicated that a large number of genes involved in metabolism were significantly lower in the PD fecal microbiome, whereas genes involved in lipopolysaccharide biosynthesis and type III bacterial secretion systems were significantly higher in PD patients.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This report provides evidence that proinflammatory dysbiosis is present in PD patients and could trigger inflammation-induced misfolding of α-Syn and development of PD pathology.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Keshavarzian</LastName><ForeName>Ali</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pharmacology, Rush University Medical Center, Chicago, Illinois, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Physiology, Rush University Medical Center, Chicago, Illinois, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Green</LastName><ForeName>Stefan J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>DNA Services Facility, Research Resources Center, University of Illinois at Chicago, Chicago, Illinois, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Engen</LastName><ForeName>Phillip A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Voigt</LastName><ForeName>Robin M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Naqib</LastName><ForeName>Ankur</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>DNA Services Facility, Research Resources Center, University of Illinois at Chicago, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Forsyth</LastName><ForeName>Christopher B</ForeName><Initials>CB</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry, Rush University Medical Center, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mutlu</LastName><ForeName>Ece</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shannon</LastName><ForeName>Kathleen M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Department of Neurology, Rush University Medical Center, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>07</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">a-synuclein</Keyword><Keyword MajorTopicYN="N">colonic mucosa and feces</Keyword><Keyword MajorTopicYN="N">dysbiosis</Keyword><Keyword MajorTopicYN="N">microbiota</Keyword><Keyword MajorTopicYN="N">putative butyrate producing short-chain fatty acids</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>1</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>5</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>5</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>7</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>7</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>7</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26179554</ArticleId><ArticleId IdType="doi">10.1002/mds.26307</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Keshavarzian, Ali" sort="Keshavarzian, Ali" uniqKey="Keshavarzian A" first="Ali" last="Keshavarzian">Ali Keshavarzian</name></region><name sortKey="Engen, Phillip A" sort="Engen, Phillip A" uniqKey="Engen P" first="Phillip A" last="Engen">Phillip A. Engen</name><name sortKey="Forsyth, Christopher B" sort="Forsyth, Christopher B" uniqKey="Forsyth C" first="Christopher B" last="Forsyth">Christopher B. Forsyth</name><name sortKey="Green, Stefan J" sort="Green, Stefan J" uniqKey="Green S" first="Stefan J" last="Green">Stefan J. Green</name><name sortKey="Mutlu, Ece" sort="Mutlu, Ece" uniqKey="Mutlu E" first="Ece" last="Mutlu">Ece Mutlu</name><name sortKey="Naqib, Ankur" sort="Naqib, Ankur" uniqKey="Naqib A" first="Ankur" last="Naqib">Ankur Naqib</name><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name><name sortKey="Voigt, Robin M" sort="Voigt, Robin M" uniqKey="Voigt R" first="Robin M" last="Voigt">Robin M. Voigt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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