Functional connectivity changes related to cognitive and motor performance in spinocerebellar ataxia type 2.
Identifieur interne : 000234 ( PubMed/Checkpoint ); précédent : 000233; suivant : 000235Functional connectivity changes related to cognitive and motor performance in spinocerebellar ataxia type 2.
Auteurs : Carlos R. Hernandez-Castillo [Mexique] ; Víctor Galvez [Mexique] ; Roberto E. Mercadillo [Mexique] ; Rosalinda Díaz [Mexique] ; Petra Yescas [Mexique] ; Leticia Martinez [Mexique] ; Adriana Ochoa [Mexique] ; Luis Velazquez-Perez [Cuba] ; Juan Fernandez-Ruiz [Mexique]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Several neuropathological studies in spinocerebellar ataxia type 2 (SCA2) have revealed significant atrophy of the cerebellum, brainstem, sensorimotor cortex, and several regions in the frontal lobe. However, the impact of the neurodegeneration on the functional integration of the remaining tissue is unknown. To analyze the clinical impact of these functional changes, we correlated the abnormal functional connectivity found in SCA2 patients with their scores in clinical scales. To obtain the functional connectivity changes, we followed two approaches. In one we used areas with significant cerebellar gray matter atrophy as anchor seeds, and in the other we performed a whole-brain data-driven analysis.
DOI: 10.1002/mds.26320
PubMed: 26256273
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Manuel Velasco Suarez</wicri:noRegion></affiliation></author><author><name sortKey="Velazquez Perez, Luis" sort="Velazquez Perez, Luis" uniqKey="Velazquez Perez L" first="Luis" last="Velazquez-Perez">Luis Velazquez-Perez</name><affiliation wicri:level="1"><nlm:affiliation>Centro para la Investigación y Rehabilitación de las Ataxias Hereditarias, Cuba.</nlm:affiliation><country xml:lang="fr">Cuba</country><wicri:regionArea>Centro para la Investigación y Rehabilitación de las Ataxias Hereditarias</wicri:regionArea></affiliation></author><author><name sortKey="Fernandez Ruiz, Juan" sort="Fernandez Ruiz, Juan" uniqKey="Fernandez Ruiz J" first="Juan" last="Fernandez-Ruiz">Juan Fernandez-Ruiz</name><affiliation wicri:level="1"><nlm:affiliation>Programa de Doctorado en Neuroetología, Universidad Veracruzana, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Programa de Doctorado en Neuroetología, Universidad Veracruzana</wicri:regionArea><wicri:noRegion>Universidad Veracruzana</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26256273</idno><idno type="pmid">26256273</idno><idno type="doi">10.1002/mds.26320</idno><idno type="wicri:Area/PubMed/Corpus">000072</idno><idno type="wicri:Area/PubMed/Curation">000072</idno><idno type="wicri:Area/PubMed/Checkpoint">000234</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Functional connectivity changes related to cognitive and motor performance in spinocerebellar ataxia type 2.</title><author><name sortKey="Hernandez Castillo, Carlos R" sort="Hernandez Castillo, Carlos R" uniqKey="Hernandez Castillo C" first="Carlos R" last="Hernandez-Castillo">Carlos R. Hernandez-Castillo</name><affiliation wicri:level="1"><nlm:affiliation>Consejo Nacional de Ciencia y Tecnología-Cátedras-Instituto de Neuroetologia, Universidad Veracruzana, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Consejo Nacional de Ciencia y Tecnología-Cátedras-Instituto de Neuroetologia, Universidad Veracruzana</wicri:regionArea><wicri:noRegion>Universidad Veracruzana</wicri:noRegion></affiliation></author><author><name sortKey="Galvez, Victor" sort="Galvez, Victor" uniqKey="Galvez V" first="Víctor" last="Galvez">Víctor Galvez</name><affiliation wicri:level="1"><nlm:affiliation>Programa de Doctorado en Neuroetología, Universidad Veracruzana, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Programa de Doctorado en Neuroetología, Universidad Veracruzana</wicri:regionArea><wicri:noRegion>Universidad Veracruzana</wicri:noRegion></affiliation></author><author><name sortKey="Mercadillo, Roberto E" sort="Mercadillo, Roberto E" uniqKey="Mercadillo R" first="Roberto E" last="Mercadillo">Roberto E. Mercadillo</name><affiliation wicri:level="1"><nlm:affiliation>Cátedras CONACYT, Área de Neurociencias, Depto. de Biología de la Reproducción, Universidad Autónoma Metropolitana-Unidad Iztapalapa, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Cátedras CONACYT, Área de Neurociencias, Depto. de Biología de la Reproducción, Universidad Autónoma Metropolitana-Unidad Iztapalapa</wicri:regionArea><wicri:noRegion>Universidad Autónoma Metropolitana-Unidad Iztapalapa</wicri:noRegion></affiliation></author><author><name sortKey="Diaz, Rosalinda" sort="Diaz, Rosalinda" uniqKey="Diaz R" first="Rosalinda" last="Díaz">Rosalinda Díaz</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Neuropsicología, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Laboratorio de Neuropsicología, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México</wicri:regionArea><wicri:noRegion>Universidad Nacional Autónoma de México</wicri:noRegion></affiliation></author><author><name sortKey="Yescas, Petra" sort="Yescas, Petra" uniqKey="Yescas P" first="Petra" last="Yescas">Petra Yescas</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Neurogenética y Biología Molecular, Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Neurogenética y Biología Molecular, Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez</wicri:regionArea><wicri:noRegion>Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez</wicri:noRegion></affiliation></author><author><name sortKey="Martinez, Leticia" sort="Martinez, Leticia" uniqKey="Martinez L" first="Leticia" last="Martinez">Leticia Martinez</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Neurogenética y Biología Molecular, Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Neurogenética y Biología Molecular, Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez</wicri:regionArea><wicri:noRegion>Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez</wicri:noRegion></affiliation></author><author><name sortKey="Ochoa, Adriana" sort="Ochoa, Adriana" uniqKey="Ochoa A" first="Adriana" last="Ochoa">Adriana Ochoa</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Neurogenética y Biología Molecular, Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Neurogenética y Biología Molecular, Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez</wicri:regionArea><wicri:noRegion>Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez</wicri:noRegion></affiliation></author><author><name sortKey="Velazquez Perez, Luis" sort="Velazquez Perez, Luis" uniqKey="Velazquez Perez L" first="Luis" last="Velazquez-Perez">Luis Velazquez-Perez</name><affiliation wicri:level="1"><nlm:affiliation>Centro para la Investigación y Rehabilitación de las Ataxias Hereditarias, Cuba.</nlm:affiliation><country xml:lang="fr">Cuba</country><wicri:regionArea>Centro para la Investigación y Rehabilitación de las Ataxias Hereditarias</wicri:regionArea></affiliation></author><author><name sortKey="Fernandez Ruiz, Juan" sort="Fernandez Ruiz, Juan" uniqKey="Fernandez Ruiz J" first="Juan" last="Fernandez-Ruiz">Juan Fernandez-Ruiz</name><affiliation wicri:level="1"><nlm:affiliation>Programa de Doctorado en Neuroetología, Universidad Veracruzana, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Programa de Doctorado en Neuroetología, Universidad Veracruzana</wicri:regionArea><wicri:noRegion>Universidad Veracruzana</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several neuropathological studies in spinocerebellar ataxia type 2 (SCA2) have revealed significant atrophy of the cerebellum, brainstem, sensorimotor cortex, and several regions in the frontal lobe. However, the impact of the neurodegeneration on the functional integration of the remaining tissue is unknown. To analyze the clinical impact of these functional changes, we correlated the abnormal functional connectivity found in SCA2 patients with their scores in clinical scales. To obtain the functional connectivity changes, we followed two approaches. In one we used areas with significant cerebellar gray matter atrophy as anchor seeds, and in the other we performed a whole-brain data-driven analysis.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">26256273</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>03</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>10</Issue><PubDate><Year>2015</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Functional connectivity changes related to cognitive and motor performance in spinocerebellar ataxia type 2.</ArticleTitle><Pagination><MedlinePgn>1391-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26320</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Several neuropathological studies in spinocerebellar ataxia type 2 (SCA2) have revealed significant atrophy of the cerebellum, brainstem, sensorimotor cortex, and several regions in the frontal lobe. However, the impact of the neurodegeneration on the functional integration of the remaining tissue is unknown. To analyze the clinical impact of these functional changes, we correlated the abnormal functional connectivity found in SCA2 patients with their scores in clinical scales. To obtain the functional connectivity changes, we followed two approaches. In one we used areas with significant cerebellar gray matter atrophy as anchor seeds, and in the other we performed a whole-brain data-driven analysis.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Fourteen genetically confirmed SCA2 patients and aged-matched healthy controls participated in the study. Voxel-based morphometry and resting-state functional magnetic resonance imaging (fMRI) were done to analyze structural and functional brain changes. Independent component analysis and dual regression were used for intrinsic network comparison. Significant functional connectivity differences were correlated with the behavioral scores.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Seed-based analysis found reduced functional connectivity within the cerebellum and between the cerebellum and frontal/parietal cortices. Cerebellar functional connectivity increases were found with parietal, frontal, and temporal areas. Intrinsic network analysis found a functional decrease in the cerebellar network, and increase in the default-mode and fronto-parietal networks. Further analysis showed significant correlations between clinical scores and the abnormal functional connectivity strength.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our findings show significant correlations between functional connectivity changes in key areas affected in SCA2 and these patients' motor and neuropsychological impairments, adding an important insight to our understanding of the pathophysiology of SCA2.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hernandez-Castillo</LastName><ForeName>Carlos R</ForeName><Initials>CR</Initials><AffiliationInfo><Affiliation>Consejo Nacional de Ciencia y Tecnología-Cátedras-Instituto de Neuroetologia, Universidad Veracruzana, México.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galvez</LastName><ForeName>Víctor</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Programa de Doctorado en Neuroetología, Universidad Veracruzana, México.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mercadillo</LastName><ForeName>Roberto E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>Cátedras CONACYT, Área de Neurociencias, Depto. de Biología de la Reproducción, Universidad Autónoma Metropolitana-Unidad Iztapalapa, México.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Díaz</LastName><ForeName>Rosalinda</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Laboratorio de Neuropsicología, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yescas</LastName><ForeName>Petra</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Departamento de Neurogenética y Biología Molecular, Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez, México.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martinez</LastName><ForeName>Leticia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Departamento de Neurogenética y Biología Molecular, Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez, México.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ochoa</LastName><ForeName>Adriana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Departamento de Neurogenética y Biología Molecular, Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez, México.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Velazquez-Perez</LastName><ForeName>Luis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Centro para la Investigación y Rehabilitación de las Ataxias Hereditarias, Cuba.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandez-Ruiz</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Programa de Doctorado en Neuroetología, Universidad Veracruzana, México.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratorio de Neuropsicología, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Facultad de Psicología, Universidad Veracruzana, México.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>08</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">SARA</Keyword><Keyword MajorTopicYN="N">Spinocerebellar ataxia type 2</Keyword><Keyword MajorTopicYN="N">cerebellum</Keyword><Keyword MajorTopicYN="N">functional connectivity</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>1</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>4</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>5</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>8</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26256273</ArticleId><ArticleId IdType="doi">10.1002/mds.26320</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Cuba</li><li>Mexique</li></country></list><tree><country name="Mexique"><noRegion><name sortKey="Hernandez Castillo, Carlos R" sort="Hernandez Castillo, Carlos R" uniqKey="Hernandez Castillo C" first="Carlos R" last="Hernandez-Castillo">Carlos R. Hernandez-Castillo</name></noRegion><name sortKey="Diaz, Rosalinda" sort="Diaz, Rosalinda" uniqKey="Diaz R" first="Rosalinda" last="Díaz">Rosalinda Díaz</name><name sortKey="Fernandez Ruiz, Juan" sort="Fernandez Ruiz, Juan" uniqKey="Fernandez Ruiz J" first="Juan" last="Fernandez-Ruiz">Juan Fernandez-Ruiz</name><name sortKey="Galvez, Victor" sort="Galvez, Victor" uniqKey="Galvez V" first="Víctor" last="Galvez">Víctor Galvez</name><name sortKey="Martinez, Leticia" sort="Martinez, Leticia" uniqKey="Martinez L" first="Leticia" last="Martinez">Leticia Martinez</name><name sortKey="Mercadillo, Roberto E" sort="Mercadillo, Roberto E" uniqKey="Mercadillo R" first="Roberto E" last="Mercadillo">Roberto E. Mercadillo</name><name sortKey="Ochoa, Adriana" sort="Ochoa, Adriana" uniqKey="Ochoa A" first="Adriana" last="Ochoa">Adriana Ochoa</name><name sortKey="Yescas, Petra" sort="Yescas, Petra" uniqKey="Yescas P" first="Petra" last="Yescas">Petra Yescas</name></country><country name="Cuba"><noRegion><name sortKey="Velazquez Perez, Luis" sort="Velazquez Perez, Luis" uniqKey="Velazquez Perez L" first="Luis" last="Velazquez-Perez">Luis Velazquez-Perez</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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