Genetic risk and age in Parkinson's disease: Continuum not stratum.
Identifieur interne : 000227 ( PubMed/Checkpoint ); précédent : 000226; suivant : 000228Genetic risk and age in Parkinson's disease: Continuum not stratum.
Auteurs : Mike A. Nalls [États-Unis] ; Valentina Escott-Price [Royaume-Uni] ; Nigel M. Williams [Royaume-Uni] ; Steven Lubbe [Royaume-Uni] ; Margaux F. Keller [États-Unis] ; Huw R. Morris [Royaume-Uni] ; Andrew B. Singleton [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Recent genomewide association study meta-analyses have identified 28 loci associated with risk of Parkinson's disease (PD). We sought to investigate whether these genetic risk factors are associated with PD age at onset.
DOI: 10.1002/mds.26192
PubMed: 25778492
Affiliations:
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Nalls</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Escott Price, Valentina" sort="Escott Price, Valentina" uniqKey="Escott Price V" first="Valentina" last="Escott-Price">Valentina Escott-Price</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="Williams, Nigel M" sort="Williams, Nigel M" uniqKey="Williams N" first="Nigel M" last="Williams">Nigel M. Williams</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="Lubbe, Steven" sort="Lubbe, Steven" uniqKey="Lubbe S" first="Steven" last="Lubbe">Steven Lubbe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Neuroscience, UCL Institute of Neurology, London, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neuroscience, UCL Institute of Neurology, London, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Keller, Margaux F" sort="Keller, Margaux F" uniqKey="Keller M" first="Margaux F" last="Keller">Margaux F. 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Nalls</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Escott Price, Valentina" sort="Escott Price, Valentina" uniqKey="Escott Price V" first="Valentina" last="Escott-Price">Valentina Escott-Price</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="Williams, Nigel M" sort="Williams, Nigel M" uniqKey="Williams N" first="Nigel M" last="Williams">Nigel M. Williams</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="Lubbe, Steven" sort="Lubbe, Steven" uniqKey="Lubbe S" first="Steven" last="Lubbe">Steven Lubbe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Neuroscience, UCL Institute of Neurology, London, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neuroscience, UCL Institute of Neurology, London, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Keller, Margaux F" sort="Keller, Margaux F" uniqKey="Keller M" first="Margaux F" last="Keller">Margaux F. Keller</name><affiliation wicri:level="2"><nlm:affiliation>Merck Research Laboratories, Cambridge, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck Research Laboratories, Cambridge, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Morris, Huw R" sort="Morris, Huw R" uniqKey="Morris H" first="Huw R" last="Morris">Huw R. Morris</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Neuroscience, UCL Institute of Neurology, London, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neuroscience, UCL Institute of Neurology, London, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B" last="Singleton">Andrew B. Singleton</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent genomewide association study meta-analyses have identified 28 loci associated with risk of Parkinson's disease (PD). We sought to investigate whether these genetic risk factors are associated with PD age at onset.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">25778492</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>20</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>May</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Genetic risk and age in Parkinson's disease: Continuum not stratum.</ArticleTitle><Pagination><MedlinePgn>850-4</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26192</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Recent genomewide association study meta-analyses have identified 28 loci associated with risk of Parkinson's disease (PD). We sought to investigate whether these genetic risk factors are associated with PD age at onset.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Genetic risk scores from these loci were calculated for 6,249 cases. Linear regression tested associations between cumulative genetic risk and PD age at onset.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Increasing genetic risk scores were associated with earlier age at onset (beta = -0.10, P = 2.92 × 10(-8) , adjusted r(2) = 0.27). Single standard deviation increase in genetic risk score is associated with 37.44 d earlier age at onset. Highest genetic risk was found at 31 to 60 y, onset slightly below average age at onset (AAO).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Common genetic risk factors have a small but consistent association with AAO in PD.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nalls</LastName><ForeName>Mike A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Escott-Price</LastName><ForeName>Valentina</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Williams</LastName><ForeName>Nigel M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lubbe</LastName><ForeName>Steven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Clinical Neuroscience, UCL Institute of Neurology, London, England, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keller</LastName><ForeName>Margaux F</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>Merck Research Laboratories, Cambridge, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morris</LastName><ForeName>Huw R</ForeName><Initials>HR</Initials><AffiliationInfo><Affiliation>Department of Clinical Neuroscience, UCL Institute of Neurology, London, England, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singleton</LastName><ForeName>Andrew B</ForeName><Initials>AB</Initials><AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>International Parkinson's Disease Genomics Consortium (IPDGC)</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G0700943</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G1100643</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">age at onset</Keyword><Keyword MajorTopicYN="N">genetics</Keyword><Keyword MajorTopicYN="N">statistics</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>11</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>1</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>3</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25778492</ArticleId><ArticleId IdType="doi">10.1002/mds.26192</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Maryland</li><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Nalls, Mike A" sort="Nalls, Mike A" uniqKey="Nalls M" first="Mike A" last="Nalls">Mike A. Nalls</name></region><name sortKey="Keller, Margaux F" sort="Keller, Margaux F" uniqKey="Keller M" first="Margaux F" last="Keller">Margaux F. Keller</name><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B" last="Singleton">Andrew B. Singleton</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Escott Price, Valentina" sort="Escott Price, Valentina" uniqKey="Escott Price V" first="Valentina" last="Escott-Price">Valentina Escott-Price</name></noRegion><name sortKey="Lubbe, Steven" sort="Lubbe, Steven" uniqKey="Lubbe S" first="Steven" last="Lubbe">Steven Lubbe</name><name sortKey="Morris, Huw R" sort="Morris, Huw R" uniqKey="Morris H" first="Huw R" last="Morris">Huw R. Morris</name><name sortKey="Williams, Nigel M" sort="Williams, Nigel M" uniqKey="Williams N" first="Nigel M" last="Williams">Nigel M. Williams</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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