High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry.
Identifieur interne : 000218 ( PubMed/Checkpoint ); précédent : 000217; suivant : 000219High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry.
Auteurs : Nadya Pyatigorskaya [France] ; Michael Sharman [France] ; Jean-Christophe Corvol [France] ; Romain Valabregue [France] ; Lydia Yahia-Cherif [France] ; Fabrice Poupon [France] ; Florence Cormier-Dequaire [France] ; Hartwig Siebner ; Stephan Klebe [France] ; Marie Vidailhet [France] ; Alexis Brice [France] ; Stephane Lehéricy [France]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
The goal of this work was to investigate iron deposition in the basal ganglia and thalamus in symptomatic and asymptomatic leucine-rich repeat kinase 2 (LRRK2) and Parkin-associated Parkinson's disease (PD), using R2* relaxometry rate.
DOI: 10.1002/mds.26218
PubMed: 26011561
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nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stephane" last="Lehéricy">Stephane Lehéricy</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26011561</idno><idno type="pmid">26011561</idno><idno type="doi">10.1002/mds.26218</idno><idno type="wicri:Area/PubMed/Corpus">000161</idno><idno type="wicri:Area/PubMed/Curation">000161</idno><idno type="wicri:Area/PubMed/Checkpoint">000218</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry.</title><author><name sortKey="Pyatigorskaya, Nadya" sort="Pyatigorskaya, Nadya" uniqKey="Pyatigorskaya N" first="Nadya" last="Pyatigorskaya">Nadya Pyatigorskaya</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sharman, Michael" sort="Sharman, Michael" uniqKey="Sharman M" first="Michael" last="Sharman">Michael Sharman</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Corvol, Jean Christophe" sort="Corvol, Jean Christophe" uniqKey="Corvol J" first="Jean-Christophe" last="Corvol">Jean-Christophe Corvol</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Valabregue, Romain" sort="Valabregue, Romain" uniqKey="Valabregue R" first="Romain" last="Valabregue">Romain Valabregue</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Yahia Cherif, Lydia" sort="Yahia Cherif, Lydia" uniqKey="Yahia Cherif L" first="Lydia" last="Yahia-Cherif">Lydia Yahia-Cherif</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Poupon, Fabrice" sort="Poupon, Fabrice" uniqKey="Poupon F" first="Fabrice" last="Poupon">Fabrice Poupon</name><affiliation wicri:level="1"><nlm:affiliation>NeuroSpin, Commissariat à l'Energie Atomique (CEA), Gif-Sur-Yvette, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>NeuroSpin, Commissariat à l'Energie Atomique (CEA), Gif-Sur-Yvette</wicri:regionArea><placeName><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation></author><author><name sortKey="Cormier Dequaire, Florence" sort="Cormier Dequaire, Florence" uniqKey="Cormier Dequaire F" first="Florence" last="Cormier-Dequaire">Florence Cormier-Dequaire</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Siebner, Hartwig" sort="Siebner, Hartwig" uniqKey="Siebner H" first="Hartwig" last="Siebner">Hartwig Siebner</name><affiliation><nlm:affiliation>Hvidovre Hospital, University of Copenhagen, Centre for Functional and Diagnostic Imaging and Research, Danish Research Centre for Magnetic Resonance (DRCMR).</nlm:affiliation><wicri:noCountry code="subField">Danish Research Centre for Magnetic Resonance (DRCMR)</wicri:noCountry></affiliation></author><author><name sortKey="Klebe, Stephan" sort="Klebe, Stephan" uniqKey="Klebe S" first="Stephan" last="Klebe">Stephan Klebe</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><affiliation wicri:level="4"><nlm:affiliation>ICM, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm UMR-S1127; CNRS, UMR 7225, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>ICM, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm UMR-S1127; CNRS, UMR 7225, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stephane" last="Lehéricy">Stephane Lehéricy</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The goal of this work was to investigate iron deposition in the basal ganglia and thalamus in symptomatic and asymptomatic leucine-rich repeat kinase 2 (LRRK2) and Parkin-associated Parkinson's disease (PD), using R2* relaxometry rate.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">26011561</PMID><DateCreated><Year>2015</Year><Month>07</Month><Day>16</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>8</Issue><PubDate><Year>2015</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry.</ArticleTitle><Pagination><MedlinePgn>1077-84</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26218</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The goal of this work was to investigate iron deposition in the basal ganglia and thalamus in symptomatic and asymptomatic leucine-rich repeat kinase 2 (LRRK2) and Parkin-associated Parkinson's disease (PD), using R2* relaxometry rate.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Twenty subjects with genetic PD (four symptomatic and two asymptomatic Parkin subjects, nine symptomatic and five asymptomatic LRRK2 subjects) were compared with 20 patients with idiopathic PD (IPD) and 20 healthy subjects. Images were obtained at 3 teslas, using multi-echo T2 and T2* sequences. R2 and R2* values were calculated in the substantia nigra (SN), the striatum, the globus pallidus, and the thalamus.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The R2* values in the SN were increased in IPD and mutation-carrying patients as compared with controls and in mutation-carrying patients as compared with IPD. Asymptomatic mutation carriers showed higher R2* values than controls and did not differ from IPD patients. No changes were seen in the other structures or in R2 values.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">These results are consistent with increased iron load in LRRK2- and Parkin-mutation carriers. The increased R2* in asymptomatic PD-mutation carriers suggests that iron deposition occurs early during the preclinical phase of the disease. R2* measurements may be used as markers for investigating nigrostriatal damage in preclinical mutation-carrying patients.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pyatigorskaya</LastName><ForeName>Nadya</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Assistance Publique Hôpitaux de Paris, Service de neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharman</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corvol</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ICM, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm UMR-S1127; CNRS, UMR 7225, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Assistance Publique Hôpitaux de Paris, INSERM, Centre d'Investigation Clinique (CIC9503), Département des Maladies du Système Nerveux, Pitié-Salpêtrière Hospital, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valabregue</LastName><ForeName>Romain</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ICM, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm UMR-S1127; CNRS, UMR 7225, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yahia-Cherif</LastName><ForeName>Lydia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Assistance Publique Hôpitaux de Paris, Service de neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ICM, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm UMR-S1127; CNRS, UMR 7225, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poupon</LastName><ForeName>Fabrice</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>NeuroSpin, Commissariat à l'Energie Atomique (CEA), Gif-Sur-Yvette, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cormier-Dequaire</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ICM, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm UMR-S1127; CNRS, UMR 7225, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Assistance Publique Hôpitaux de Paris, INSERM, Centre d'Investigation Clinique (CIC9503), Département des Maladies du Système Nerveux, Pitié-Salpêtrière Hospital, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siebner</LastName><ForeName>Hartwig</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Hvidovre Hospital, University of Copenhagen, Centre for Functional and Diagnostic Imaging and Research, Danish Research Centre for Magnetic Resonance (DRCMR).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klebe</LastName><ForeName>Stephan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ICM, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm UMR-S1127; CNRS, UMR 7225, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Assistance Publique Hôpitaux de Paris, INSERM, Centre d'Investigation Clinique (CIC9503), Département des Maladies du Système Nerveux, Pitié-Salpêtrière Hospital, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Assistance Publique Hôpitaux de Paris, Département de Génétique et Cytogénétique, Hôpital Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University Hospital of Würzburg, Würzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vidailhet</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>ICM, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm UMR-S1127; CNRS, UMR 7225, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Assistance Publique Hôpitaux de Paris, Clinique des mouvements anormaux, Département des Maladies du Système Nerveux, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brice</LastName><ForeName>Alexis</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ICM, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm UMR-S1127; CNRS, UMR 7225, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Assistance Publique Hôpitaux de Paris, Département de Génétique et Cytogénétique, Hôpital Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lehéricy</LastName><ForeName>Stephane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Assistance Publique Hôpitaux de Paris, Service de neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ICM, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm UMR-S1127; CNRS, UMR 7225, Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">LRRK2</Keyword><Keyword MajorTopicYN="N">MRI</Keyword><Keyword MajorTopicYN="N">Parkin</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">relaxometry</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>1</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>2</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>3</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>5</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26011561</ArticleId><ArticleId IdType="doi">10.1002/mds.26218</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Gif-sur-Yvette</li><li>Paris</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><noCountry><name sortKey="Siebner, Hartwig" sort="Siebner, Hartwig" uniqKey="Siebner H" first="Hartwig" last="Siebner">Hartwig Siebner</name></noCountry><country name="France"><noRegion><name sortKey="Pyatigorskaya, Nadya" sort="Pyatigorskaya, Nadya" uniqKey="Pyatigorskaya N" first="Nadya" last="Pyatigorskaya">Nadya Pyatigorskaya</name></noRegion><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Cormier Dequaire, Florence" sort="Cormier Dequaire, Florence" uniqKey="Cormier Dequaire F" first="Florence" last="Cormier-Dequaire">Florence Cormier-Dequaire</name><name sortKey="Corvol, Jean Christophe" sort="Corvol, Jean Christophe" uniqKey="Corvol J" first="Jean-Christophe" last="Corvol">Jean-Christophe Corvol</name><name sortKey="Klebe, Stephan" sort="Klebe, Stephan" uniqKey="Klebe S" first="Stephan" last="Klebe">Stephan Klebe</name><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stephane" last="Lehéricy">Stephane Lehéricy</name><name sortKey="Poupon, Fabrice" sort="Poupon, Fabrice" uniqKey="Poupon F" first="Fabrice" last="Poupon">Fabrice Poupon</name><name sortKey="Sharman, Michael" sort="Sharman, Michael" uniqKey="Sharman M" first="Michael" last="Sharman">Michael Sharman</name><name sortKey="Valabregue, Romain" sort="Valabregue, Romain" uniqKey="Valabregue R" first="Romain" last="Valabregue">Romain Valabregue</name><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><name sortKey="Yahia Cherif, Lydia" sort="Yahia Cherif, Lydia" uniqKey="Yahia Cherif L" first="Lydia" last="Yahia-Cherif">Lydia Yahia-Cherif</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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