Cognition in Movement Disorders: Where Can We Hope to be in Ten Years?
Identifieur interne : 000402 ( Pmc/Curation ); précédent : 000401; suivant : 000403Cognition in Movement Disorders: Where Can We Hope to be in Ten Years?
Auteurs : David Burn [Royaume-Uni] ; Daniel Weintraub [États-Unis] ; Bernard Ravina [États-Unis] ; Irene Litvan [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
Abstract
Cognitive impairment and dementia associated with movement disorders represent a major management challenge and area of unmet need. This article has focused upon Parkinson’s disease as an exemplar condition, but many of the roadblocks and efforts to overcome these are applicable, in a general sense, to other disorders. Short of a “penicillin moment”—a chance discovery or piece of unintended good fortune—progress is likely to be incremental. Cognitive therapies may end up being multiple and possibly multimodal, parallel with the cancer therapy field. Ultimately, benefit for one condition may extend to others as commonality in protein aggregation, synergistic pathological effects between proteins, and pathological spread emerges.
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DOI: 10.1002/mds.25850
PubMed: 24757118
PubMed Central: 4371593
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This article has focused upon Parkinson’s disease as an exemplar condition, but many of the roadblocks and efforts to overcome these are applicable, in a general sense, to other disorders. Short of a “penicillin moment”—a chance discovery or piece of unintended good fortune—progress is likely to be incremental. Cognitive therapies may end up being multiple and possibly multimodal, parallel with the cancer therapy field. Ultimately, benefit for one condition may extend to others as commonality in protein aggregation, synergistic pathological effects between proteins, and pathological spread emerges.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24757118</article-id><article-id pub-id-type="pmc">4371593</article-id><article-id pub-id-type="doi">10.1002/mds.25850</article-id><article-id pub-id-type="manuscript">NIHMS671144</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Cognition in Movement Disorders: Where Can We Hope to be in Ten Years?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Burn</surname><given-names>David</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Weintraub</surname><given-names>Daniel</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ravina</surname><given-names>Bernard</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Litvan</surname><given-names>Irene</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, UK</aff><aff id="A2"><label>2</label>Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA</aff><aff id="A3"><label>3</label>Neurology Clinical Development, Biogen Idec, Cambridge, Massachusetts, USA</aff><aff id="A4"><label>4</label>Movement Disorder Center, Department of Neurosciences, University of California, San Diego, California, USA</aff><author-notes><corresp id="cor1"><label>*</label><bold>Correspondence to:</bold> Dr. David J. Burn, Clinical Aging Research Unit, Newcastle University, Campus for Aging and Vitality, Newcastle upon Tyne, NE4 5PL, UK; <email>david.burn@ncl.ac.uk</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>4</month><year>2015</year></pub-date><volume>29</volume><issue>5</issue><fpage>704</fpage><lpage>711</lpage><pmc-comment>elocation-id from pubmed: 10.1002/mds.25850</pmc-comment>
<permissions><copyright-statement>© 2014 International Parkinson and Movement Disorder Society</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p id="P1">Cognitive impairment and dementia associated with movement disorders represent a major management challenge and area of unmet need. This article has focused upon Parkinson’s disease as an exemplar condition, but many of the roadblocks and efforts to overcome these are applicable, in a general sense, to other disorders. Short of a “penicillin moment”—a chance discovery or piece of unintended good fortune—progress is likely to be incremental. Cognitive therapies may end up being multiple and possibly multimodal, parallel with the cancer therapy field. Ultimately, benefit for one condition may extend to others as commonality in protein aggregation, synergistic pathological effects between proteins, and pathological spread emerges.</p></abstract><kwd-group><kwd>Parkinson’s disease</kwd><kwd>dementia</kwd><kwd>cognitive testing</kwd><kwd>biomarkers</kwd><kwd>therapeutics</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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