Cognitive impairment in multiple system atrophy
Identifieur interne : 000395 ( Pmc/Curation ); précédent : 000394; suivant : 000396Cognitive impairment in multiple system atrophy
Auteurs : Iva Stankovic [Serbie] ; Florian Krismer [Autriche] ; Aleksandar Jesic [Serbie] ; Angelo Antonini [Italie] ; Thomas Benke [Autriche] ; Richard G. Brown [Royaume-Uni] ; David J. Burn [Royaume-Uni] ; Janice L. Holton [Royaume-Uni] ; Horacio Kaufmann [États-Unis] ; Vladimir S. Kostic [Serbie] ; Helen Ling [Royaume-Uni] ; Wassilios G. Meissner [France] ; Werner Poewe [Autriche] ; Marija Semnic [Serbie] ; Klaus Seppi [Autriche] ; Atsushi Takeda [Japon] ; Daniel Weintraub [États-Unis] ; Gregor K. Wenning [Autriche]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
Abstract
Consensus diagnostic criteria for multiple system atrophy consider dementia as a non-supporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal-executive dysfunction is the most common presentation, while memory and visuospatial functions may also be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidence-based review we here propose future avenues of research that may ultimately lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy.
Url:
DOI: 10.1002/mds.25880
PubMed: 24753321
PubMed Central: 4175376
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<author><name sortKey="Kostic, Vladimir S" sort="Kostic, Vladimir S" uniqKey="Kostic V" first="Vladimir S." last="Kostic">Vladimir S. Kostic</name>
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<front><div type="abstract" xml:lang="en"><p id="P1">Consensus diagnostic criteria for multiple system atrophy consider dementia as a non-supporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal-executive dysfunction is the most common presentation, while memory and visuospatial functions may also be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidence-based review we here propose future avenues of research that may ultimately lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy.</p>
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<title-group><article-title>Cognitive impairment in multiple system atrophy</article-title>
<subtitle>A position statement by the Neuropsychology Task Force of the MDS multiple system atrophy (MODIMSA) Study Group</subtitle>
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<contrib-group><contrib contrib-type="author"><name><surname>Stankovic</surname>
<given-names>Iva</given-names>
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<contrib contrib-type="author"><name><surname>Krismer</surname>
<given-names>Florian</given-names>
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<contrib contrib-type="author"><name><surname>Jesic</surname>
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<contrib contrib-type="author"><name><surname>Antonini</surname>
<given-names>Angelo</given-names>
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<given-names>Thomas</given-names>
</name>
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<contrib contrib-type="author"><name><surname>Brown</surname>
<given-names>Richard G.</given-names>
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<given-names>Janice L.</given-names>
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<contrib contrib-type="author"><name><surname>Kostic</surname>
<given-names>Vladimir S.</given-names>
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<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ling</surname>
<given-names>Helen</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meissner</surname>
<given-names>Wassilios G.</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Poewe</surname>
<given-names>Werner</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Semnic</surname>
<given-names>Marija</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Seppi</surname>
<given-names>Klaus</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Takeda</surname>
<given-names>Atsushi</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weintraub</surname>
<given-names>Daniel</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wenning</surname>
<given-names>Gregor K.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><collab>on behalf of the Movement Disorders Society MSA (MODIMSA) Study Group</collab>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia</aff>
<aff id="A2"><label>2</label>
Department of Neurology, Innsbruck Medical University, Austria</aff>
<aff id="A3"><label>3</label>
Neurology Clinic, Clinical Centre of Vojvodina, Novi Sad, Serbia</aff>
<aff id="A4"><label>4</label>
Department for Parkinson's Disease, “Fondazione Ospedale San Camillo,” I.R.C.C.S., Venice, Italy</aff>
<aff id="A5"><label>5</label>
King's College London, Institute of Psychiatry, Department of Psychology, London, SE5 8AF, UK</aff>
<aff id="A6"><label>6</label>
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE4 5PL, UK</aff>
<aff id="A7"><label>7</label>
Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, University College London, London, UK</aff>
<aff id="A8"><label>8</label>
Dysautonomia Center, Langone Medical Center, New York University, New York, USA</aff>
<aff id="A9"><label>9</label>
Univ. de Bordeaux, Institut des Maladies Neurodégénératives, CNRS UMR 5293, F-33000 Bordeaux, France</aff>
<aff id="A10"><label>10</label>
Department of Neurology, National Hospital Organization Sendai Nishitaga Hospital, Sendai, Japan</aff>
<aff id="A11"><label>11</label>
Departments of Psychiatry and Neurology, Perelman School of Medicine at the University of Pennsylvania, and Parkinson's Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania</aff>
<author-notes><corresp id="FN1">Correspondence To: Prof. Gregor K. Wenning MD, PhD, MSC, Department of Neurology, Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria, Phone: +43 512 504 818 11, <email>gregor.wenning@i-med.ac.at</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>21</day>
<month>6</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>18</day>
<month>4</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>6</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>6</month>
<year>2015</year>
</pub-date>
<volume>29</volume>
<issue>7</issue>
<fpage>857</fpage>
<lpage>867</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/mds.25880</pmc-comment>
<abstract><p id="P1">Consensus diagnostic criteria for multiple system atrophy consider dementia as a non-supporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal-executive dysfunction is the most common presentation, while memory and visuospatial functions may also be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidence-based review we here propose future avenues of research that may ultimately lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy.</p>
</abstract>
<kwd-group><kwd>cognition</kwd>
<kwd>multiple system atrophy</kwd>
<kwd>neuropsychology</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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