RELATIONSHIP BETWEEN PROPRIOCEPTION AT THE KNEE JOINT AND GAIT ATAXIA IN HSAN III
Identifieur interne : 000328 ( Pmc/Curation ); précédent : 000327; suivant : 000329RELATIONSHIP BETWEEN PROPRIOCEPTION AT THE KNEE JOINT AND GAIT ATAXIA IN HSAN III
Auteurs : Vaughan G. Macefield [Australie] ; Lucy J. Norcliffe-Kaufmann [États-Unis] ; Felicia B. Axelrod [États-Unis] ; Horacio Kaufmann [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
Abstract
Hereditary sensory and autonomic neuropathy type III features a marked ataxic gait that progressively worsens over time. We assessed whether proprioceptive disturbances can explain the ataxia. Proprioception at the knee joint was assessed using passive joint angle matching in 18 patients and 14 age-matched controls; 5 patients with cerebellar ataxia were also studied. Ataxia was quantified using the Brief Ataxia Rating Score, which ranged from 7 to 26/30. Neuropathy patients performed poorly in judging joint position: mean absolute error was 8.7±1.0° and the range was very wide (2.8–18.1°); conversely, absolute error was only 2.7±0.3° (1.6–5.5°) in the controls and 3.0±0.2° (2.1–3.4°) in the cerebellar patients. This error was positively correlated to the degree of ataxia in the neuropathy patients but not the cerebellar patients, suggesting that poor proprioceptive acuity at the knee joint is a major contributor to the ataxic gait associated with hereditary sensory and autonomic neuropathy type III.
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DOI: 10.1002/mds.25482
PubMed: 23681701
PubMed Central: 3694996
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Vaughan G. Macefield<affiliation><nlm:aff id="A2">School of Medicine, University of Western Sydney</nlm:aff><wicri:noCountry code="subfield">University of Western Sydney</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Neuroscience Research Australia, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroscience Research Australia, Sydney</wicri:regionArea></affiliation>Le document en format XML
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Norcliffe-Kaufmann</name><affiliation wicri:level="1"><nlm:aff id="A1">Dysautonomia Center, NYU Langone Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dysautonomia Center, NYU Langone Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Axelrod, Felicia B" sort="Axelrod, Felicia B" uniqKey="Axelrod F" first="Felicia B." last="Axelrod">Felicia B. 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We assessed whether proprioceptive disturbances can explain the ataxia. Proprioception at the knee joint was assessed using passive joint angle matching in 18 patients and 14 age-matched controls; 5 patients with cerebellar ataxia were also studied. Ataxia was quantified using the Brief Ataxia Rating Score, which ranged from 7 to 26/30. Neuropathy patients performed poorly in judging joint position: mean absolute error was 8.7±1.0° and the range was very wide (2.8–18.1°); conversely, absolute error was only 2.7±0.3° (1.6–5.5°) in the controls and 3.0±0.2° (2.1–3.4°) in the cerebellar patients. This error was positively correlated to the degree of ataxia in the neuropathy patients but not the cerebellar patients, suggesting that poor proprioceptive acuity at the knee joint is a major contributor to the ataxic gait associated with hereditary sensory and autonomic neuropathy type III.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23681701</article-id><article-id pub-id-type="pmc">3694996</article-id><article-id pub-id-type="doi">10.1002/mds.25482</article-id><article-id pub-id-type="manuscript">NIHMS467271</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>RELATIONSHIP BETWEEN PROPRIOCEPTION AT THE KNEE JOINT AND GAIT ATAXIA IN HSAN III</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Macefield</surname><given-names>Vaughan G.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Norcliffe-Kaufmann</surname><given-names>Lucy J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Axelrod</surname><given-names>Felicia B.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kaufmann</surname><given-names>Horacio</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Dysautonomia Center, NYU Langone Medical Center, New York, USA</aff><aff id="A2"><label>2</label>School of Medicine, University of Western Sydney</aff><aff id="A3"><label>3</label>Neuroscience Research Australia, Sydney, Australia</aff><author-notes><corresp id="FN1">Corresponding author: Prof Vaughan Macefield, School of Medicine, University of Western Sydney, Locked Bag 1797, Penrith NSW 2751, Australia, Phone: +61 2 4620 3779, Fax: +61 2 4620 3890, <email>v.macefield@uws.edu.au</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>16</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>16</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>6</month><year>2014</year></pub-date><volume>28</volume><issue>6</issue><fpage>823</fpage><lpage>827</lpage><abstract><p id="P1">Hereditary sensory and autonomic neuropathy type III features a marked ataxic gait that progressively worsens over time. We assessed whether proprioceptive disturbances can explain the ataxia. Proprioception at the knee joint was assessed using passive joint angle matching in 18 patients and 14 age-matched controls; 5 patients with cerebellar ataxia were also studied. Ataxia was quantified using the Brief Ataxia Rating Score, which ranged from 7 to 26/30. Neuropathy patients performed poorly in judging joint position: mean absolute error was 8.7±1.0° and the range was very wide (2.8–18.1°); conversely, absolute error was only 2.7±0.3° (1.6–5.5°) in the controls and 3.0±0.2° (2.1–3.4°) in the cerebellar patients. This error was positively correlated to the degree of ataxia in the neuropathy patients but not the cerebellar patients, suggesting that poor proprioceptive acuity at the knee joint is a major contributor to the ataxic gait associated with hereditary sensory and autonomic neuropathy type III.</p></abstract><kwd-group><kwd>congenital insensitivity to pain</kwd><kwd>familial dysautonomia</kwd><kwd>joint sense</kwd><kwd>hereditary sensory & autonomic neuropathy</kwd><kwd>muscle spindles</kwd><kwd>proprioception</kwd><kwd>Riley-Day syndrome</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>U54 NS065736 || NS</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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