The Inferior Olivary Nucleus: A Postmortem Study of Essential Tremor Cases vs. Controls
Identifieur interne : 000317 ( Pmc/Curation ); précédent : 000316; suivant : 000318The Inferior Olivary Nucleus: A Postmortem Study of Essential Tremor Cases vs. Controls
Auteurs : Elan D. Louis [États-Unis] ; Rachel Babij [États-Unis] ; Etty Cortés [États-Unis] ; Jean-Paul G. Vonsattel [États-Unis] ; Phyllis L. Faust [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
Abstract
The pathogenesis of essential tremor is poorly understood. Historically, the inferior olivary nucleus has been hypothesized to play an important role in the generation of tremor in essential tremor, yet a detailed, controlled, anatomic-pathological study of that brain region has yet to be conducted.
A detailed postmortem study was undertaken of the microscopic changes in the inferior olivary nucleus of 14 essential tremor cases vs. 15 age-matched controls at the Essential Tremor Centralized Brain Repository. A series of metrics was used to quantify microscopic neuronal and glial changes in the inferior olivary nucleus and its input and output tracts. Olivary linear neuronal density was also assessed.
Cases and controls did not differ from one another with respect to any of the assessed metrics (p values ranged from 0.23 – 1.0). Olivary linear neuronal density was also similar in cases and controls (p = 0.62). Paddle-shaped neurons, a morphologic shape change in olivary neurons, which to our knowledge have not been previously recognized, occurred to an equal degree in ET cases and controls (p = 0.89), and correlated with several markers of neuronal loss and gliosis.
A systematic postmortem study of the microscopic changes in the inferior olivary nucleus did not detect any differences between cases and controls. These data, along with positron emission tomography data, which have failed to identify any metabolic abnormality of the olive, indicate that if the olive is involved in essential tremor, there is no clearly identifiable structural or metabolic correlate.
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DOI: 10.1002/mds.25400
PubMed: 23483605
PubMed Central: 3688649
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Louis</name><affiliation wicri:level="1"><nlm:aff id="A1">GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Babij, Rachel" sort="Babij, Rachel" uniqKey="Babij R" first="Rachel" last="Babij">Rachel Babij</name><affiliation wicri:level="1"><nlm:aff id="A1">GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Cortes, Etty" sort="Cortes, Etty" uniqKey="Cortes E" first="Etty" last="Cortés">Etty Cortés</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Pathology and Cell Biology, Columbia University Medical Center and the New York Presbyterian Hospital, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pathology and Cell Biology, Columbia University Medical Center and the New York Presbyterian Hospital, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Vonsattel, Jean Paul G" sort="Vonsattel, Jean Paul G" uniqKey="Vonsattel J" first="Jean-Paul G." last="Vonsattel">Jean-Paul G. Vonsattel</name><affiliation wicri:level="1"><nlm:aff id="A2">Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Department of Pathology and Cell Biology, Columbia University Medical Center and the New York Presbyterian Hospital, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pathology and Cell Biology, Columbia University Medical Center and the New York Presbyterian Hospital, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Faust, Phyllis L" sort="Faust, Phyllis L" uniqKey="Faust P" first="Phyllis L." last="Faust">Phyllis L. Faust</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Pathology and Cell Biology, Columbia University Medical Center and the New York Presbyterian Hospital, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pathology and Cell Biology, Columbia University Medical Center and the New York Presbyterian Hospital, New York, NY</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">The pathogenesis of essential tremor is poorly understood. Historically, the inferior olivary nucleus has been hypothesized to play an important role in the generation of tremor in essential tremor, yet a detailed, controlled, anatomic-pathological study of that brain region has yet to be conducted.</p></sec><sec id="S2"><title>Methods</title><p id="P2">A detailed postmortem study was undertaken of the microscopic changes in the inferior olivary nucleus of 14 essential tremor cases vs. 15 age-matched controls at the Essential Tremor Centralized Brain Repository. A series of metrics was used to quantify microscopic neuronal and glial changes in the inferior olivary nucleus and its input and output tracts. Olivary linear neuronal density was also assessed.</p></sec><sec id="S3"><title>Results</title><p id="P3">Cases and controls did not differ from one another with respect to any of the assessed metrics (p values ranged from 0.23 – 1.0). Olivary linear neuronal density was also similar in cases and controls (p = 0.62). Paddle-shaped neurons, a morphologic shape change in olivary neurons, which to our knowledge have not been previously recognized, occurred to an equal degree in ET cases and controls (p = 0.89), and correlated with several markers of neuronal loss and gliosis.</p></sec><sec id="S4"><title>Discussion</title><p id="P4">A systematic postmortem study of the microscopic changes in the inferior olivary nucleus did not detect any differences between cases and controls. These data, along with positron emission tomography data, which have failed to identify any metabolic abnormality of the olive, indicate that if the olive is involved in essential tremor, there is no clearly identifiable structural or metabolic correlate.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23483605</article-id><article-id pub-id-type="pmc">3688649</article-id><article-id pub-id-type="doi">10.1002/mds.25400</article-id><article-id pub-id-type="manuscript">NIHMS439523</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The Inferior Olivary Nucleus: A Postmortem Study of Essential Tremor Cases vs. Controls</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Louis</surname><given-names>Elan D.</given-names></name><degrees>MD MSc</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Babij</surname><given-names>Rachel</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Cortés</surname><given-names>Etty</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Vonsattel</surname><given-names>Jean-Paul G.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Faust</surname><given-names>Phyllis L.</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib></contrib-group><aff id="A1"><label>1</label>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</aff><aff id="A2"><label>2</label>Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</aff><aff id="A3"><label>3</label>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</aff><aff id="A4"><label>4</label>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.</aff><aff id="A5"><label>5</label>Department of Pathology and Cell Biology, Columbia University Medical Center and the New York Presbyterian Hospital, New York, NY, USA.</aff><author-notes><corresp id="cor1"><bold>Correspondence:</bold> Dr. Elan Louis, Unit 198, Neurological Institute, 710 West 168<sup>th</sup> Street, New York, NY, 10032, USA. Tel: (212) 305 – 9194, FAX: (212) 305-1304, <email>EDL2@columbia.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>31</day><month>1</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>11</day><month>3</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>6</month><year>2014</year></pub-date><volume>28</volume><issue>6</issue><fpage>779</fpage><lpage>786</lpage><abstract><sec id="S1"><title>Background</title><p id="P1">The pathogenesis of essential tremor is poorly understood. Historically, the inferior olivary nucleus has been hypothesized to play an important role in the generation of tremor in essential tremor, yet a detailed, controlled, anatomic-pathological study of that brain region has yet to be conducted.</p></sec><sec id="S2"><title>Methods</title><p id="P2">A detailed postmortem study was undertaken of the microscopic changes in the inferior olivary nucleus of 14 essential tremor cases vs. 15 age-matched controls at the Essential Tremor Centralized Brain Repository. A series of metrics was used to quantify microscopic neuronal and glial changes in the inferior olivary nucleus and its input and output tracts. Olivary linear neuronal density was also assessed.</p></sec><sec id="S3"><title>Results</title><p id="P3">Cases and controls did not differ from one another with respect to any of the assessed metrics (p values ranged from 0.23 – 1.0). Olivary linear neuronal density was also similar in cases and controls (p = 0.62). Paddle-shaped neurons, a morphologic shape change in olivary neurons, which to our knowledge have not been previously recognized, occurred to an equal degree in ET cases and controls (p = 0.89), and correlated with several markers of neuronal loss and gliosis.</p></sec><sec id="S4"><title>Discussion</title><p id="P4">A systematic postmortem study of the microscopic changes in the inferior olivary nucleus did not detect any differences between cases and controls. These data, along with positron emission tomography data, which have failed to identify any metabolic abnormality of the olive, indicate that if the olive is involved in essential tremor, there is no clearly identifiable structural or metabolic correlate.</p></sec></abstract><kwd-group><kwd>essential tremor</kwd><kwd>brain</kwd><kwd>pathology</kwd><kwd>inferior olivary nucleus</kwd><kwd>pathophysiology</kwd><kwd>neurodegenerative</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>R01 NS042859 || NS</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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