Brain dynamic neurochemical changes in dystonic patients: a magnetic resonance spectroscopy study
Identifieur interne : 000302 ( Pmc/Curation ); précédent : 000301; suivant : 000303Brain dynamic neurochemical changes in dystonic patients: a magnetic resonance spectroscopy study
Auteurs : M. Marja Ska [États-Unis] ; S. Lehéricy [France] ; R. Valabregue [France] ; T. Popa [France] ; Y. Worbe [France] ; M. Russo [France] ; E. J. Auerbach [États-Unis] ; D. Grabli [France] ; C. Bonnet [France, République tchèque] ; C. Gallea [France] ; M. Coudert [France] ; L. Yahia-Cherif [France] ; M. Vidailhet [France] ; S. Meunier [France]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.
Abstract
Measurements of the concentrations of γ-aminobutyric acid (GABA) and glutamate in the motor cortex and lentiform nucleus of dystonic patients using single voxel 1H magnetic resonance spectroscopy (MRS) have yielded conflicting results so far. This study aimed at investigating dynamic changes in metabolite concentrations after stimulation of the motor cortex in patients with upper limb dystonia.
Using single voxel MRS at 3 T, the concentrations of GABA, glutamate plus glutamine, and
At baseline, there was no group difference in concentration of metabolites in any of the regions. rTMS induced a local (in the stimulated motor cortex) decrease of
The stimulation-induced changes in metabolite concentrations are interpreted in the view of the increased energy demand induced by rTMS. Dynamics of the GABA concentration are specifically impaired in dystonic patients. Whether these changes reflect changes in the extra synaptic or synaptic GABA component is discussed.
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DOI: 10.1002/mds.25279
PubMed: 23239076
PubMed Central: 4410978
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Worbe</name><affiliation wicri:level="1"><nlm:aff id="A3">Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">CNRS, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 7225, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Inserm, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">ICM – Institut du Cerveau et de la Moelle épinière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>ICM – Institut du Cerveau et de la Moelle épinière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Russo, M" sort="Russo, M" uniqKey="Russo M" first="M." last="Russo">M. 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Bonnet</name><affiliation wicri:level="1"><nlm:aff id="A8">Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Clinical Research Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clinical Research Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Department of Biostatistics and Medical Informatics, Pitié-Salpêtrière Hospital, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics and Medical Informatics, Pitié-Salpêtrière Hospital, AP-HP, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Department of Neurology, Charles University in Prague, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Neurology, Charles University in Prague, First Faculty of Medicine and General Teaching Hospital, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Gallea, C" sort="Gallea, C" uniqKey="Gallea C" first="C." last="Gallea">C. Gallea</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre de NeuroImagerie de Recherche – CENIR, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de NeuroImagerie de Recherche – CENIR, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Coudert, M" sort="Coudert, M" uniqKey="Coudert M" first="M." last="Coudert">M. Coudert</name><affiliation wicri:level="1"><nlm:aff id="A9">Clinical Research Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clinical Research Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Department of Biostatistics and Medical Informatics, Pitié-Salpêtrière Hospital, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics and Medical Informatics, Pitié-Salpêtrière Hospital, AP-HP, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Yahia Cherif, L" sort="Yahia Cherif, L" uniqKey="Yahia Cherif L" first="L." last="Yahia-Cherif">L. Yahia-Cherif</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre de NeuroImagerie de Recherche – CENIR, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de NeuroImagerie de Recherche – CENIR, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">CNRS, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 7225, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Inserm, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U975, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M." last="Vidailhet">M. Vidailhet</name><affiliation wicri:level="1"><nlm:aff id="A3">Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">CNRS, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 7225, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Inserm, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">ICM – Institut du Cerveau et de la Moelle épinière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>ICM – Institut du Cerveau et de la Moelle épinière, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Meunier, S" sort="Meunier, S" uniqKey="Meunier S" first="S." last="Meunier">S. Meunier</name><affiliation wicri:level="1"><nlm:aff id="A3">Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">CNRS, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 7225, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Inserm, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">ICM – Institut du Cerveau et de la Moelle épinière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>ICM – Institut du Cerveau et de la Moelle épinière, Paris</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23239076</idno><idno type="pmc">4410978</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410978</idno><idno type="RBID">PMC:4410978</idno><idno type="doi">10.1002/mds.25279</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000302</idno><idno type="wicri:Area/Pmc/Curation">000302</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Brain dynamic neurochemical changes in dystonic patients: a magnetic resonance spectroscopy study</title><author><name sortKey="Marja Ska, M" sort="Marja Ska, M" uniqKey="Marja Ska M" first="M." last="Marja Ska">M. Marja Ska</name><affiliation wicri:level="1"><nlm:aff id="A1">Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis</wicri:regionArea></affiliation></author><author><name sortKey="Lehericy, S" sort="Lehericy, S" uniqKey="Lehericy S" first="S." last="Lehéricy">S. Lehéricy</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre de NeuroImagerie de Recherche – CENIR, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de NeuroImagerie de Recherche – CENIR, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">CNRS, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 7225, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Inserm, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">ICM – Institut du Cerveau et de la Moelle épinière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>ICM – Institut du Cerveau et de la Moelle épinière, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Department of Neuroradiology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neuroradiology, Groupe Hospitalier Pitié-Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Valabregue, R" sort="Valabregue, R" uniqKey="Valabregue R" first="R." last="Valabregue">R. Valabregue</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre de NeuroImagerie de Recherche – CENIR, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de NeuroImagerie de Recherche – CENIR, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Popa, T" sort="Popa, T" uniqKey="Popa T" first="T." last="Popa">T. Popa</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre de NeuroImagerie de Recherche – CENIR, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de NeuroImagerie de Recherche – CENIR, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">CNRS, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 7225, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Inserm, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">ICM – Institut du Cerveau et de la Moelle épinière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>ICM – Institut du Cerveau et de la Moelle épinière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Worbe, Y" sort="Worbe, Y" uniqKey="Worbe Y" first="Y." last="Worbe">Y. Worbe</name><affiliation wicri:level="1"><nlm:aff id="A3">Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">CNRS, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 7225, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Inserm, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">ICM – Institut du Cerveau et de la Moelle épinière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>ICM – Institut du Cerveau et de la Moelle épinière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Russo, M" sort="Russo, M" uniqKey="Russo M" first="M." last="Russo">M. Russo</name><affiliation wicri:level="1"><nlm:aff id="A3">Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">CNRS, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 7225, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Inserm, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U975, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Auerbach, E J" sort="Auerbach, E J" uniqKey="Auerbach E" first="E. J." last="Auerbach">E. J. Auerbach</name><affiliation wicri:level="1"><nlm:aff id="A1">Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis</wicri:regionArea></affiliation></author><author><name sortKey="Grabli, D" sort="Grabli, D" uniqKey="Grabli D" first="D." last="Grabli">D. Grabli</name><affiliation wicri:level="1"><nlm:aff id="A8">Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Bonnet, C" sort="Bonnet, C" uniqKey="Bonnet C" first="C." last="Bonnet">C. Bonnet</name><affiliation wicri:level="1"><nlm:aff id="A8">Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Clinical Research Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clinical Research Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Department of Biostatistics and Medical Informatics, Pitié-Salpêtrière Hospital, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics and Medical Informatics, Pitié-Salpêtrière Hospital, AP-HP, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Department of Neurology, Charles University in Prague, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Neurology, Charles University in Prague, First Faculty of Medicine and General Teaching Hospital, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Gallea, C" sort="Gallea, C" uniqKey="Gallea C" first="C." last="Gallea">C. Gallea</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre de NeuroImagerie de Recherche – CENIR, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de NeuroImagerie de Recherche – CENIR, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Coudert, M" sort="Coudert, M" uniqKey="Coudert M" first="M." last="Coudert">M. Coudert</name><affiliation wicri:level="1"><nlm:aff id="A9">Clinical Research Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clinical Research Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Department of Biostatistics and Medical Informatics, Pitié-Salpêtrière Hospital, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics and Medical Informatics, Pitié-Salpêtrière Hospital, AP-HP, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Yahia Cherif, L" sort="Yahia Cherif, L" uniqKey="Yahia Cherif L" first="L." last="Yahia-Cherif">L. Yahia-Cherif</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre de NeuroImagerie de Recherche – CENIR, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de NeuroImagerie de Recherche – CENIR, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">CNRS, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 7225, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Inserm, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U975, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M." last="Vidailhet">M. Vidailhet</name><affiliation wicri:level="1"><nlm:aff id="A3">Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">CNRS, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 7225, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Inserm, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">ICM – Institut du Cerveau et de la Moelle épinière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>ICM – Institut du Cerveau et de la Moelle épinière, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Meunier, S" sort="Meunier, S" uniqKey="Meunier S" first="S." last="Meunier">S. Meunier</name><affiliation wicri:level="1"><nlm:aff id="A3">Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">CNRS, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 7225, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Inserm, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U975, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">ICM – Institut du Cerveau et de la Moelle épinière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>ICM – Institut du Cerveau et de la Moelle épinière, Paris</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Measurements of the concentrations of γ-aminobutyric acid (GABA) and glutamate in the motor cortex and lentiform nucleus of dystonic patients using single voxel <sup>1</sup>H magnetic resonance spectroscopy (MRS) have yielded conflicting results so far. This study aimed at investigating dynamic changes in metabolite concentrations after stimulation of the motor cortex in patients with upper limb dystonia.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Using single voxel MRS at 3 T, the concentrations of GABA, glutamate plus glutamine, and <italic>N</italic>-acetylaspartate were measured bilaterally in the primary sensorimotor cortex, lentiform nucleus, and occipital region before and after 5 Hz transcranial magnetic stimulation (TMS) over the dominant motor cortex. Data obtained from 15 patients with upper limb primary dystonia were compared to data obtained from 14 healthy volunteers.</p></sec><sec id="S3"><title>Results</title><p id="P3">At baseline, there was no group difference in concentration of metabolites in any of the regions. rTMS induced a local (in the stimulated motor cortex) decrease of <italic>N</italic>-acetylaspartate (p < 0.006) to the same extent in healthy volunteers and patients. GABA concentrations were modulated differently, however, decreasing mildly in patients and increasing mildly in healthy volunteers (p = 0.05). There were no remote effects in the lentiform nucleus in either group.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">The stimulation-induced changes in metabolite concentrations are interpreted in the view of the increased energy demand induced by rTMS. Dynamics of the GABA concentration are specifically impaired in dystonic patients. Whether these changes reflect changes in the extra synaptic or synaptic GABA component is discussed.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23239076</article-id><article-id pub-id-type="pmc">4410978</article-id><article-id pub-id-type="doi">10.1002/mds.25279</article-id><article-id pub-id-type="manuscript">NIHMS680282</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Brain dynamic neurochemical changes in dystonic patients: a magnetic resonance spectroscopy study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Marjańska</surname><given-names>M.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lehéricy</surname><given-names>S.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Valabregue</surname><given-names>R.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Popa</surname><given-names>T.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Worbe</surname><given-names>Y.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Russo</surname><given-names>M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Auerbach</surname><given-names>E.J.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Grabli</surname><given-names>D.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Bonnet</surname><given-names>C.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Gallea</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Coudert</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Yahia-Cherif</surname><given-names>L.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Vidailhet</surname><given-names>M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Meunier</surname><given-names>S.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib></contrib-group><aff id="A1"><label>1</label>Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, USA</aff><aff id="A2"><label>2</label>Centre de NeuroImagerie de Recherche – CENIR, Paris, France</aff><aff id="A3"><label>3</label>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de, l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</aff><aff id="A4"><label>4</label>CNRS, UMR 7225, Paris, France</aff><aff id="A5"><label>5</label>Inserm, U975, Paris, France</aff><aff id="A6"><label>6</label>ICM – Institut du Cerveau et de la Moelle épinière, Paris, France</aff><aff id="A7"><label>7</label>Department of Neuroradiology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</aff><aff id="A8"><label>8</label>Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</aff><aff id="A9"><label>9</label>Clinical Research Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris, France</aff><aff id="A10"><label>10</label>Department of Biostatistics and Medical Informatics, Pitié-Salpêtrière Hospital, AP-HP, Paris, France</aff><aff id="A11"><label>11</label>Department of Neurology, Charles University in Prague, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author: Sabine Meunier, M.D., Ph.D. bâtiment ICM CIC, room 1040, Groupe Hospitalier Pitié-Salpêtrière, 47 boulevard de l’Hôpital, 75013 Paris, France, phone: +33142165777, fax: +33142162474, <email>sabine.meunier@upmc.fr</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>16</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>12</day><month>12</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>27</day><month>4</month><year>2015</year></pub-date><volume>28</volume><issue>2</issue><fpage>201</fpage><lpage>209</lpage><pmc-comment>elocation-id from pubmed: 10.1002/mds.25279</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">Measurements of the concentrations of γ-aminobutyric acid (GABA) and glutamate in the motor cortex and lentiform nucleus of dystonic patients using single voxel <sup>1</sup>H magnetic resonance spectroscopy (MRS) have yielded conflicting results so far. This study aimed at investigating dynamic changes in metabolite concentrations after stimulation of the motor cortex in patients with upper limb dystonia.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Using single voxel MRS at 3 T, the concentrations of GABA, glutamate plus glutamine, and <italic>N</italic>-acetylaspartate were measured bilaterally in the primary sensorimotor cortex, lentiform nucleus, and occipital region before and after 5 Hz transcranial magnetic stimulation (TMS) over the dominant motor cortex. Data obtained from 15 patients with upper limb primary dystonia were compared to data obtained from 14 healthy volunteers.</p></sec><sec id="S3"><title>Results</title><p id="P3">At baseline, there was no group difference in concentration of metabolites in any of the regions. rTMS induced a local (in the stimulated motor cortex) decrease of <italic>N</italic>-acetylaspartate (p < 0.006) to the same extent in healthy volunteers and patients. GABA concentrations were modulated differently, however, decreasing mildly in patients and increasing mildly in healthy volunteers (p = 0.05). There were no remote effects in the lentiform nucleus in either group.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">The stimulation-induced changes in metabolite concentrations are interpreted in the view of the increased energy demand induced by rTMS. Dynamics of the GABA concentration are specifically impaired in dystonic patients. Whether these changes reflect changes in the extra synaptic or synaptic GABA component is discussed.</p></sec></abstract><kwd-group><kwd>gamma-aminobutyric acid (GABA)</kwd><kwd>NAA</kwd><kwd>transcranial magnetic stimulation</kwd><kwd>dystonia</kwd><kwd>spectroscopy</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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