Regional Alterations of Brain Microstructure in Parkinson's Disease Using Diffusion Tensor Imaging
Identifieur interne : 000250 ( Pmc/Curation ); précédent : 000249; suivant : 000251Regional Alterations of Brain Microstructure in Parkinson's Disease Using Diffusion Tensor Imaging
Auteurs : W. Zhan [États-Unis] ; G. A. Kang [États-Unis] ; G. A. Glass [États-Unis] ; Y. Zhang [États-Unis] ; C. Shirley [États-Unis] ; R. Millin [États-Unis] ; K. L. Possin [États-Unis] ; M. Nezamzadeh [États-Unis] ; M. W. Weiner [États-Unis] ; W. J. Marks [États-Unis] ; N. Schuff [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2011.
Abstract
This study tested the hypothesis that diffusion tensor imaging (DTI) can detect alteration in microscopic integrity of white matter (WM) and basal ganglia (BG) regions known to be involved in Parkinson's disease (PD) pathology. It was also hypothesized that there is an association between the DTI abnormality and PD severity and subtype. DTI at 4 Tesla was obtained in 12 PD and 20 control subjects. The DTI measures of fractional anisotropy (FA) and mean diffusivity (MD) were evaluated using both region of interest (ROI) and voxel-based methods. Movement deficits in PD subjects were assessed using Motor Subscale (Part III) of the Unified Parkinson's Disease Rating Scale (UPDRS). Subtype determination of movement deficits was derived based upon results of subjects’ UPDRS ratings. Reduced FA (p<0.05, corrected) was found in PD subjects in a number of regions, including the precentral gyrus, substantia nigra, putamen, posterior striatum, frontal WM, and in regions related to the supplementary motor areas. Reduced FA in the substantia nigra correlated (p<0.05, corrected) with increased UPDRS motor scores. Significant spatial correlations between FA alterations in putamen and other PD-affected regions were also found in the context of PD subtypes index analysis. Our data suggest that microstructural alterations detected with DTI might serve as a potential biomarker for PD.
Url:
DOI: 10.1002/mds.23917
PubMed: 21850668
PubMed Central: 4472452
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000250
Links to Exploration step
PMC:4472452Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regional Alterations of Brain Microstructure in Parkinson's Disease Using Diffusion Tensor Imaging</title><author><name sortKey="Zhan, W" sort="Zhan, W" uniqKey="Zhan W" first="W." last="Zhan">W. Zhan</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author><author><name sortKey="Kang, G A" sort="Kang, G A" uniqKey="Kang G" first="G. A." last="Kang">G. A. Kang</name><affiliation wicri:level="1"><nlm:aff id="A2"> Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, 4150 Clement Street, 127P, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, 4150 Clement Street, 127P, San Francisco, CA 94121</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Neurology, University of California, San Francisco, CA 94143, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, University of California, San Francisco, CA 94143</wicri:regionArea></affiliation></author><author><name sortKey="Glass, G A" sort="Glass, G A" uniqKey="Glass G" first="G. A." last="Glass">G. A. Glass</name><affiliation wicri:level="1"><nlm:aff id="A2"> Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, 4150 Clement Street, 127P, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, 4150 Clement Street, 127P, San Francisco, CA 94121</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Neurology, University of California, San Francisco, CA 94143, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, University of California, San Francisco, CA 94143</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Y" sort="Zhang, Y" uniqKey="Zhang Y" first="Y." last="Zhang">Y. Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author><author><name sortKey="Shirley, C" sort="Shirley, C" uniqKey="Shirley C" first="C." last="Shirley">C. Shirley</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author><author><name sortKey="Millin, R" sort="Millin, R" uniqKey="Millin R" first="R." last="Millin">R. Millin</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author><author><name sortKey="Possin, K L" sort="Possin, K L" uniqKey="Possin K" first="K. L." last="Possin">K. L. Possin</name><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Neurology, University of California, San Francisco, CA 94143, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, University of California, San Francisco, CA 94143</wicri:regionArea></affiliation></author><author><name sortKey="Nezamzadeh, M" sort="Nezamzadeh, M" uniqKey="Nezamzadeh M" first="M." last="Nezamzadeh">M. Nezamzadeh</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author><author><name sortKey="Weiner, M W" sort="Weiner, M W" uniqKey="Weiner M" first="M. W." last="Weiner">M. W. Weiner</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author><author><name sortKey="Marks, W J" sort="Marks, W J" uniqKey="Marks W" first="W. J." last="Marks">W. J. Marks</name><affiliation wicri:level="1"><nlm:aff id="A2"> Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, 4150 Clement Street, 127P, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, 4150 Clement Street, 127P, San Francisco, CA 94121</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Neurology, University of California, San Francisco, CA 94143, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, University of California, San Francisco, CA 94143</wicri:regionArea></affiliation></author><author><name sortKey="Schuff, N" sort="Schuff, N" uniqKey="Schuff N" first="N." last="Schuff">N. Schuff</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21850668</idno><idno type="pmc">4472452</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472452</idno><idno type="RBID">PMC:4472452</idno><idno type="doi">10.1002/mds.23917</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000250</idno><idno type="wicri:Area/Pmc/Curation">000250</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Regional Alterations of Brain Microstructure in Parkinson's Disease Using Diffusion Tensor Imaging</title><author><name sortKey="Zhan, W" sort="Zhan, W" uniqKey="Zhan W" first="W." last="Zhan">W. Zhan</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author><author><name sortKey="Kang, G A" sort="Kang, G A" uniqKey="Kang G" first="G. A." last="Kang">G. A. Kang</name><affiliation wicri:level="1"><nlm:aff id="A2"> Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, 4150 Clement Street, 127P, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, 4150 Clement Street, 127P, San Francisco, CA 94121</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Neurology, University of California, San Francisco, CA 94143, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, University of California, San Francisco, CA 94143</wicri:regionArea></affiliation></author><author><name sortKey="Glass, G A" sort="Glass, G A" uniqKey="Glass G" first="G. A." last="Glass">G. A. Glass</name><affiliation wicri:level="1"><nlm:aff id="A2"> Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, 4150 Clement Street, 127P, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, 4150 Clement Street, 127P, San Francisco, CA 94121</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Neurology, University of California, San Francisco, CA 94143, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, University of California, San Francisco, CA 94143</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Y" sort="Zhang, Y" uniqKey="Zhang Y" first="Y." last="Zhang">Y. Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author><author><name sortKey="Shirley, C" sort="Shirley, C" uniqKey="Shirley C" first="C." last="Shirley">C. Shirley</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author><author><name sortKey="Millin, R" sort="Millin, R" uniqKey="Millin R" first="R." last="Millin">R. Millin</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author><author><name sortKey="Possin, K L" sort="Possin, K L" uniqKey="Possin K" first="K. L." last="Possin">K. L. Possin</name><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Neurology, University of California, San Francisco, CA 94143, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, University of California, San Francisco, CA 94143</wicri:regionArea></affiliation></author><author><name sortKey="Nezamzadeh, M" sort="Nezamzadeh, M" uniqKey="Nezamzadeh M" first="M." last="Nezamzadeh">M. Nezamzadeh</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author><author><name sortKey="Weiner, M W" sort="Weiner, M W" uniqKey="Weiner M" first="M. W." last="Weiner">M. W. Weiner</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author><author><name sortKey="Marks, W J" sort="Marks, W J" uniqKey="Marks W" first="W. J." last="Marks">W. J. Marks</name><affiliation wicri:level="1"><nlm:aff id="A2"> Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, 4150 Clement Street, 127P, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, 4150 Clement Street, 127P, San Francisco, CA 94121</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Neurology, University of California, San Francisco, CA 94143, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, University of California, San Francisco, CA 94143</wicri:regionArea></affiliation></author><author><name sortKey="Schuff, N" sort="Schuff, N" uniqKey="Schuff N" first="N." last="Schuff">N. Schuff</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">This study tested the hypothesis that diffusion tensor imaging (DTI) can detect alteration in microscopic integrity of white matter (WM) and basal ganglia (BG) regions known to be involved in Parkinson's disease (PD) pathology. It was also hypothesized that there is an association between the DTI abnormality and PD severity and subtype. DTI at 4 Tesla was obtained in 12 PD and 20 control subjects. The DTI measures of fractional anisotropy (FA) and mean diffusivity (MD) were evaluated using both region of interest (ROI) and voxel-based methods. Movement deficits in PD subjects were assessed using Motor Subscale (Part III) of the Unified Parkinson's Disease Rating Scale (UPDRS). Subtype determination of movement deficits was derived based upon results of subjects’ UPDRS ratings. Reduced FA (p<0.05, corrected) was found in PD subjects in a number of regions, including the precentral gyrus, substantia nigra, putamen, posterior striatum, frontal WM, and in regions related to the supplementary motor areas. Reduced FA in the substantia nigra correlated (p<0.05, corrected) with increased UPDRS motor scores. Significant spatial correlations between FA alterations in putamen and other PD-affected regions were also found in the context of PD subtypes index analysis. Our data suggest that microstructural alterations detected with DTI might serve as a potential biomarker for PD.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21850668</article-id><article-id pub-id-type="pmc">4472452</article-id><article-id pub-id-type="doi">10.1002/mds.23917</article-id><article-id pub-id-type="manuscript">NIHMS690020</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Regional Alterations of Brain Microstructure in Parkinson's Disease Using Diffusion Tensor Imaging</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhan</surname><given-names>W.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>G.A.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Glass</surname><given-names>G.A.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Y.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shirley</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Millin</surname><given-names>R.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Possin</surname><given-names>K.L.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Nezamzadeh</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Weiner</surname><given-names>M.W.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Marks</surname><given-names>W.J.</given-names><suffix>Jr.</suffix></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Schuff</surname><given-names>N.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label> Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.</aff><aff id="A2"><label>2</label> Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, 4150 Clement Street, 127P, San Francisco, CA 94121, USA.</aff><aff id="A3"><label>3</label> Department of Neurology, University of California, San Francisco, CA 94143, USA</aff><author-notes><corresp id="CR1"><label>*</label> Correspondence should be addressed to: Wang Zhan, Ph.D. Department of Radiology University of California San Francisco VA Medical Center 114M 4150 Clement Street, San Francisco, CA 94121, USA Tel: 415-221-4810x6454 Fax: 415-668-2864 <email>Wang.Zhan@gmail.com</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>5</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>17</day><month>8</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>18</day><month>6</month><year>2015</year></pub-date><volume>27</volume><issue>1</issue><fpage>90</fpage><lpage>97</lpage><pmc-comment>elocation-id from pubmed: 10.1002/mds.23917</pmc-comment>
<abstract><p id="P1">This study tested the hypothesis that diffusion tensor imaging (DTI) can detect alteration in microscopic integrity of white matter (WM) and basal ganglia (BG) regions known to be involved in Parkinson's disease (PD) pathology. It was also hypothesized that there is an association between the DTI abnormality and PD severity and subtype. DTI at 4 Tesla was obtained in 12 PD and 20 control subjects. The DTI measures of fractional anisotropy (FA) and mean diffusivity (MD) were evaluated using both region of interest (ROI) and voxel-based methods. Movement deficits in PD subjects were assessed using Motor Subscale (Part III) of the Unified Parkinson's Disease Rating Scale (UPDRS). Subtype determination of movement deficits was derived based upon results of subjects’ UPDRS ratings. Reduced FA (p<0.05, corrected) was found in PD subjects in a number of regions, including the precentral gyrus, substantia nigra, putamen, posterior striatum, frontal WM, and in regions related to the supplementary motor areas. Reduced FA in the substantia nigra correlated (p<0.05, corrected) with increased UPDRS motor scores. Significant spatial correlations between FA alterations in putamen and other PD-affected regions were also found in the context of PD subtypes index analysis. Our data suggest that microstructural alterations detected with DTI might serve as a potential biomarker for PD.</p></abstract><kwd-group><kwd>diffusion tensor imaging</kwd><kwd>magnetic resonance imaging</kwd><kwd>Parkinson's disease</kwd><kwd>Subtypes</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000250 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000250 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:4472452
|texte= Regional Alterations of Brain Microstructure in Parkinson's Disease Using Diffusion Tensor Imaging
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:21850668" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |