TESTING OBJECTIVE MEASURES OF MOTOR IMPAIRMENT IN EARLY PARKINSON’S DISEASE: FEASIBILITY STUDY OF AN AT-HOME TESTING DEVICE
Identifieur interne : 000206 ( Pmc/Curation ); précédent : 000205; suivant : 000207TESTING OBJECTIVE MEASURES OF MOTOR IMPAIRMENT IN EARLY PARKINSON’S DISEASE: FEASIBILITY STUDY OF AN AT-HOME TESTING DEVICE
Auteurs : Christopher G. Goetz [États-Unis] ; Glenn T. Stebbins [États-Unis] ; David Wolff [États-Unis] ; William Deleeuw [États-Unis] ; Helen Bronte-Stewart [États-Unis] ; Rodger Elble [États-Unis] ; Mark Hallett [États-Unis] ; John Nutt [États-Unis] ; Lorraine Ramig [États-Unis] ; Terence Sanger [États-Unis] ; Allan D. Wu [États-Unis] ; Peter H. Kraus [Allemagne] ; Lucia M. Blasucci [États-Unis] ; Ejaz A. Shamim [États-Unis] ; Kapil D. Sethi [États-Unis] ; Jennifer Spielman [États-Unis] ; Ken Kubota [États-Unis] ; Andrew S. Grove [États-Unis] ; Eric Dishman [États-Unis] ; C Barr Taylor [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2009.
Abstract
We tested the feasibility of a computer based at-home testing device (AHTD) in early-stage, unmedicated Parkinson’s disease (PD) patients over 6 months. We measured compliance, technical reliability, and patient satisfaction to weekly assessments of tremor, small and large muscle bradykinesia, speech, reaction/movement times, and complex motor control. relative to the UPDRS motor score. The AHTD is a 6.5 x 10 computerized assessment battery. Data are stored on a USB memory stick and sent by internet to a central data repository as encrypted data packets. Although not designed or powered to measure change, the study collected data to observe patterns relative to UPDRS motor scores. Fifty-two PD patients enrolled, and 50 completed the six month trial, 48 remaining without medication. Patients complied with 90.6% of weekly 30-minute assessments, and 98.5% of data packets were successfully transmitted and decrypted. On a 100-point scale, patient satisfaction with the program at study end was 87.2 (range 80–100). UPDRS motor scores significantly worsened over 6 months, and trends for worsening over time occurred for alternating finger taps (p=.08), tremor (p=.06) and speech (p=.11). Change in tremor was a significant predictor of change in UPDRS (p=0.047) and was detected in the first month of the study. This new computer-based technology offers a feasible format for assessing PD-related impairment from home. The high patient compliance and satisfaction suggest the feasibility of its incorporation into larger clinical trials, especially when travel is difficult and early changes or frequent data collection are considered important to document.
Url:
DOI: 10.1002/mds.22379
PubMed: 19086085
PubMed Central: 4161502
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">TESTING OBJECTIVE MEASURES OF MOTOR IMPAIRMENT IN EARLY PARKINSON’S DISEASE: FEASIBILITY STUDY OF AN AT-HOME TESTING DEVICE</title>
<author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name>
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<author><name sortKey="Stebbins, Glenn T" sort="Stebbins, Glenn T" uniqKey="Stebbins G" first="Glenn T." last="Stebbins">Glenn T. Stebbins</name>
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<author><name sortKey="Wolff, David" sort="Wolff, David" uniqKey="Wolff D" first="David" last="Wolff">David Wolff</name>
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<author><name sortKey="Deleeuw, William" sort="Deleeuw, William" uniqKey="Deleeuw W" first="William" last="Deleeuw">William Deleeuw</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Intel Corporation, Santa Clara, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intel Corporation, Santa Clara, CA</wicri:regionArea>
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<author><name sortKey="Bronte Stewart, Helen" sort="Bronte Stewart, Helen" uniqKey="Bronte Stewart H" first="Helen" last="Bronte-Stewart">Helen Bronte-Stewart</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Palo Alto, CA</wicri:regionArea>
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<author><name sortKey="Elble, Rodger" sort="Elble, Rodger" uniqKey="Elble R" first="Rodger" last="Elble">Rodger Elble</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Southern Illinois University, Springfield, IL</wicri:regionArea>
</affiliation>
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<author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Institutes of Health, Bethesda MD</wicri:regionArea>
</affiliation>
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<author><name sortKey="Nutt, John" sort="Nutt, John" uniqKey="Nutt J" first="John" last="Nutt">John Nutt</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Oregon Health Sciences University, Portland OR</wicri:regionArea>
</affiliation>
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<author><name sortKey="Ramig, Lorraine" sort="Ramig, Lorraine" uniqKey="Ramig L" first="Lorraine" last="Ramig">Lorraine Ramig</name>
<affiliation wicri:level="1"><nlm:aff id="A8">University of Colorado, Boulder CO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Colorado, Boulder CO</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A9">National Center for Voice and Speech, Denver, CO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Center for Voice and Speech, Denver, CO</wicri:regionArea>
</affiliation>
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<author><name sortKey="Sanger, Terence" sort="Sanger, Terence" uniqKey="Sanger T" first="Terence" last="Sanger">Terence Sanger</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Stanford University, Palo Alto, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Palo Alto, CA</wicri:regionArea>
</affiliation>
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<author><name sortKey="Wu, Allan D" sort="Wu, Allan D" uniqKey="Wu A" first="Allan D." last="Wu">Allan D. Wu</name>
<affiliation wicri:level="1"><nlm:aff id="A10">University of California, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of California, Los Angeles, CA</wicri:regionArea>
</affiliation>
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<author><name sortKey="Kraus, Peter H" sort="Kraus, Peter H" uniqKey="Kraus P" first="Peter H." last="Kraus">Peter H. Kraus</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Univerität Bochum, Bochum</wicri:regionArea>
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<author><name sortKey="Blasucci, Lucia M" sort="Blasucci, Lucia M" uniqKey="Blasucci L" first="Lucia M." last="Blasucci">Lucia M. Blasucci</name>
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<placeName><region type="state">Illinois</region>
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<author><name sortKey="Shamim, Ejaz A" sort="Shamim, Ejaz A" uniqKey="Shamim E" first="Ejaz A." last="Shamim">Ejaz A. Shamim</name>
<affiliation wicri:level="1"><nlm:aff id="A6">National Institutes of Health, Bethesda MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Institutes of Health, Bethesda MD</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A12">Georgetown University Hospital, Washington DC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Georgetown University Hospital, Washington DC</wicri:regionArea>
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<author><name sortKey="Sethi, Kapil D" sort="Sethi, Kapil D" uniqKey="Sethi K" first="Kapil D." last="Sethi">Kapil D. Sethi</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical College of Georgia, Augusta, GA</wicri:regionArea>
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<author><name sortKey="Spielman, Jennifer" sort="Spielman, Jennifer" uniqKey="Spielman J" first="Jennifer" last="Spielman">Jennifer Spielman</name>
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<author><name sortKey="Kubota, Ken" sort="Kubota, Ken" uniqKey="Kubota K" first="Ken" last="Kubota">Ken Kubota</name>
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<author><name sortKey="Grove, Andrew S" sort="Grove, Andrew S" uniqKey="Grove A" first="Andrew S." last="Grove">Andrew S. Grove</name>
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<author><name sortKey="Dishman, Eric" sort="Dishman, Eric" uniqKey="Dishman E" first="Eric" last="Dishman">Eric Dishman</name>
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<author><name sortKey="Taylor, C Barr" sort="Taylor, C Barr" uniqKey="Taylor C" first="C Barr" last="Taylor">C Barr Taylor</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Kinetics Foundation, Los Altos, CA</wicri:regionArea>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
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<front><div type="abstract" xml:lang="en"><p id="P1">We tested the feasibility of a computer based at-home testing device (AHTD) in early-stage, unmedicated Parkinson’s disease (PD) patients over 6 months. We measured compliance, technical reliability, and patient satisfaction to weekly assessments of tremor, small and large muscle bradykinesia, speech, reaction/movement times, and complex motor control. relative to the UPDRS motor score. The AHTD is a 6.5 x 10 computerized assessment battery. Data are stored on a USB memory stick and sent by internet to a central data repository as encrypted data packets. Although not designed or powered to measure change, the study collected data to observe patterns relative to UPDRS motor scores. Fifty-two PD patients enrolled, and 50 completed the six month trial, 48 remaining without medication. Patients complied with 90.6% of weekly 30-minute assessments, and 98.5% of data packets were successfully transmitted and decrypted. On a 100-point scale, patient satisfaction with the program at study end was 87.2 (range 80–100). UPDRS motor scores significantly worsened over 6 months, and trends for worsening over time occurred for alternating finger taps (p=.08), tremor (p=.06) and speech (p=.11). Change in tremor was a significant predictor of change in UPDRS (p=0.047) and was detected in the first month of the study. This new computer-based technology offers a feasible format for assessing PD-related impairment from home. The high patient compliance and satisfaction suggest the feasibility of its incorporation into larger clinical trials, especially when travel is difficult and early changes or frequent data collection are considered important to document.</p>
</div>
</front>
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<article-id pub-id-type="doi">10.1002/mds.22379</article-id>
<article-id pub-id-type="manuscript">NIHMS622846</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>TESTING OBJECTIVE MEASURES OF MOTOR IMPAIRMENT IN EARLY PARKINSON’S DISEASE: FEASIBILITY STUDY OF AN AT-HOME TESTING DEVICE</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Goetz</surname>
<given-names>Christopher G.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stebbins</surname>
<given-names>Glenn T.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wolff</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>DeLeeuw</surname>
<given-names>William</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bronte-Stewart</surname>
<given-names>Helen</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Elble</surname>
<given-names>Rodger</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hallett</surname>
<given-names>Mark</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nutt</surname>
<given-names>John</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ramig</surname>
<given-names>Lorraine</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sanger</surname>
<given-names>Terence</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wu</surname>
<given-names>Allan D.</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kraus</surname>
<given-names>Peter H.</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blasucci</surname>
<given-names>Lucia M.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shamim</surname>
<given-names>Ejaz A.</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sethi</surname>
<given-names>Kapil D.</given-names>
</name>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spielman</surname>
<given-names>Jennifer</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kubota</surname>
<given-names>Ken</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grove</surname>
<given-names>Andrew S.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dishman</surname>
<given-names>Eric</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Taylor</surname>
<given-names>C Barr</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Rush University Medical Center, Chicago, IL USA</aff>
<aff id="A2"><label>2</label>
Kinetics Foundation, Los Altos, CA, USA</aff>
<aff id="A3"><label>3</label>
Intel Corporation, Santa Clara, CA, USA</aff>
<aff id="A4"><label>4</label>
Stanford University, Palo Alto, CA, USA</aff>
<aff id="A5"><label>5</label>
Southern Illinois University, Springfield, IL, USA</aff>
<aff id="A6"><label>6</label>
National Institutes of Health, Bethesda MD, USA</aff>
<aff id="A7"><label>7</label>
Oregon Health Sciences University, Portland OR, USA</aff>
<aff id="A8"><label>8</label>
University of Colorado, Boulder CO, USA</aff>
<aff id="A9"><label>9</label>
National Center for Voice and Speech, Denver, CO, USA</aff>
<aff id="A10"><label>10</label>
University of California, Los Angeles, CA, USA</aff>
<aff id="A11"><label>11</label>
Univerität Bochum, Bochum, Germany</aff>
<aff id="A12"><label>12</label>
Georgetown University Hospital, Washington DC, USA</aff>
<aff id="A13"><label>13</label>
Medical College of Georgia, Augusta, GA, USA</aff>
<author-notes><corresp id="FN1">Address correspondence to: C G Goetz, 1725 W. Harrison Street, Suite 755, Chicago, IL 60612 Telephone: 312-942-8016: FAX: 312-563-2024: <email>cgoetz@rush.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>23</day>
<month>8</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><day>15</day>
<month>3</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>11</day>
<month>9</month>
<year>2014</year>
</pub-date>
<volume>24</volume>
<issue>4</issue>
<fpage>551</fpage>
<lpage>556</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/mds.22379</pmc-comment>
<abstract><p id="P1">We tested the feasibility of a computer based at-home testing device (AHTD) in early-stage, unmedicated Parkinson’s disease (PD) patients over 6 months. We measured compliance, technical reliability, and patient satisfaction to weekly assessments of tremor, small and large muscle bradykinesia, speech, reaction/movement times, and complex motor control. relative to the UPDRS motor score. The AHTD is a 6.5 x 10 computerized assessment battery. Data are stored on a USB memory stick and sent by internet to a central data repository as encrypted data packets. Although not designed or powered to measure change, the study collected data to observe patterns relative to UPDRS motor scores. Fifty-two PD patients enrolled, and 50 completed the six month trial, 48 remaining without medication. Patients complied with 90.6% of weekly 30-minute assessments, and 98.5% of data packets were successfully transmitted and decrypted. On a 100-point scale, patient satisfaction with the program at study end was 87.2 (range 80–100). UPDRS motor scores significantly worsened over 6 months, and trends for worsening over time occurred for alternating finger taps (p=.08), tremor (p=.06) and speech (p=.11). Change in tremor was a significant predictor of change in UPDRS (p=0.047) and was detected in the first month of the study. This new computer-based technology offers a feasible format for assessing PD-related impairment from home. The high patient compliance and satisfaction suggest the feasibility of its incorporation into larger clinical trials, especially when travel is difficult and early changes or frequent data collection are considered important to document.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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