Clinical Characteristics in Early Parkinson’s Disease in a Central California Population-Based Study
Identifieur interne : 000196 ( Pmc/Curation ); précédent : 000195; suivant : 000197Clinical Characteristics in Early Parkinson’s Disease in a Central California Population-Based Study
Auteurs : Gail A. Kang [États-Unis] ; Jeff M. Bronstein [États-Unis] ; Donna L. Masterman [États-Unis] ; Matthew Redelings [États-Unis] ; Jarrod A. Crum [États-Unis] ; Beate Ritz [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
Abstract
There is considerable variation in the phenotypic appearance of individuals with idiopathic Parkinson’s disease (PD), which may translate into differences in disease progression in addition to underlying disease etiology. In this publication, we report on the demographic and clinical characteristics of 162 individuals diagnosed with clinically probable PD from January 1998 to June 2003 who resided in predominantly rural communities in central California. The majority of the subjects were Caucasian, male, and between 60 and 79 years of age. The akinetic–rigid and tremor-dominant subtypes were more common than the mixed subtype. The majority of subjects displayed motor signs of rigidity (92.0%), bradykinesia (95.7%), and gait problems (87.0%), whereas less than half (43.3%) of the subjects displayed a tremor. Three fourths of patients received a Hoehn and Yahr Scale score of Stage 2 or higher. One third of the patients were treated with levodopa, and patients under 60 years of age were more likely to be treated with dopamine agonists. Within 3 years after first diagnosis, 13% of subjects showed some signs of depression and 17% of subjects met criteria for mild dementia. Among our subjects, 17.3% reported a family history of PD in first- or second-degree relatives,15.4% a family history of essential tremor, and 14.2% of Alzheimer’s disease. This study represents the most extensive phenotypic description of rural U.S. residents in the initial stages of PD who were recruited in a population-based manner; future follow-up may provide valuable information regarding the prognostic indication of these symptoms/signs and improve our understanding of the underlying etiology of PD.
Url:
DOI: 10.1002/mds.20513
PubMed: 15954133
PubMed Central: 3643967
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<front><div type="abstract" xml:lang="en"><p id="P1">There is considerable variation in the phenotypic appearance of individuals with idiopathic Parkinson’s disease (PD), which may translate into differences in disease progression in addition to underlying disease etiology. In this publication, we report on the demographic and clinical characteristics of 162 individuals diagnosed with clinically probable PD from January 1998 to June 2003 who resided in predominantly rural communities in central California. The majority of the subjects were Caucasian, male, and between 60 and 79 years of age. The akinetic–rigid and tremor-dominant subtypes were more common than the mixed subtype. The majority of subjects displayed motor signs of rigidity (92.0%), bradykinesia (95.7%), and gait problems (87.0%), whereas less than half (43.3%) of the subjects displayed a tremor. Three fourths of patients received a Hoehn and Yahr Scale score of Stage 2 or higher. One third of the patients were treated with levodopa, and patients under 60 years of age were more likely to be treated with dopamine agonists. Within 3 years after first diagnosis, 13% of subjects showed some signs of depression and 17% of subjects met criteria for mild dementia. Among our subjects, 17.3% reported a family history of PD in first- or second-degree relatives,15.4% a family history of essential tremor, and 14.2% of Alzheimer’s disease. This study represents the most extensive phenotypic description of rural U.S. residents in the initial stages of PD who were recruited in a population-based manner; future follow-up may provide valuable information regarding the prognostic indication of these symptoms/signs and improve our understanding of the underlying etiology of PD.</p>
</div>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
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<title-group><article-title>Clinical Characteristics in Early Parkinson’s Disease in a Central California Population-Based Study</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Kang</surname>
<given-names>Gail A.</given-names>
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<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Bronstein</surname>
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<aff id="A1"><label>1</label>
Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA</aff>
<aff id="A2"><label>2</label>
Greater Los Angeles Veterans Administration Medical Center, Los Angeles, California, USA</aff>
<aff id="A3"><label>3</label>
Department of Epidemiology and Environmental Health Sciences, UCLA School of Public Health, Los Angeles, California, USA</aff>
<author-notes><corresp id="FN1"><label>*</label>
Correspondence to: Dr. Beate Ritz, UCLA School of Public Health, Box 951772, 650 Charles E. Young Drive, Los Angeles, CA 90095-1772. <email>britz@ucla.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>16</day>
<month>4</month>
<year>2013</year>
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<pub-date pub-type="ppub"><month>9</month>
<year>2005</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>03</day>
<month>5</month>
<year>2013</year>
</pub-date>
<volume>20</volume>
<issue>9</issue>
<fpage>1133</fpage>
<lpage>1142</lpage>
<permissions><copyright-statement>© 2005 Movement Disorder Society</copyright-statement>
<copyright-year>2005</copyright-year>
</permissions>
<abstract><p id="P1">There is considerable variation in the phenotypic appearance of individuals with idiopathic Parkinson’s disease (PD), which may translate into differences in disease progression in addition to underlying disease etiology. In this publication, we report on the demographic and clinical characteristics of 162 individuals diagnosed with clinically probable PD from January 1998 to June 2003 who resided in predominantly rural communities in central California. The majority of the subjects were Caucasian, male, and between 60 and 79 years of age. The akinetic–rigid and tremor-dominant subtypes were more common than the mixed subtype. The majority of subjects displayed motor signs of rigidity (92.0%), bradykinesia (95.7%), and gait problems (87.0%), whereas less than half (43.3%) of the subjects displayed a tremor. Three fourths of patients received a Hoehn and Yahr Scale score of Stage 2 or higher. One third of the patients were treated with levodopa, and patients under 60 years of age were more likely to be treated with dopamine agonists. Within 3 years after first diagnosis, 13% of subjects showed some signs of depression and 17% of subjects met criteria for mild dementia. Among our subjects, 17.3% reported a family history of PD in first- or second-degree relatives,15.4% a family history of essential tremor, and 14.2% of Alzheimer’s disease. This study represents the most extensive phenotypic description of rural U.S. residents in the initial stages of PD who were recruited in a population-based manner; future follow-up may provide valuable information regarding the prognostic indication of these symptoms/signs and improve our understanding of the underlying etiology of PD.</p>
</abstract>
<kwd-group><kwd>idiopathic Parkinson’s disease (PD)</kwd>
<kwd>phenotypic description</kwd>
<kwd>disease progression</kwd>
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<funding-group><award-group><funding-source country="United States">National Institute of Environmental Health Sciences : NIEHS</funding-source>
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