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Brain biochemistry in autopsied patients with essential tremor

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Brain biochemistry in autopsied patients with essential tremor

Auteurs : Holly A. Shill ; Charles H. Adler ; Thomas G. Beach ; Lih-Fen Lue ; John N. Caviness ; Marwan N. Sabbagh ; Lucia I. Sue ; Douglas G. Walker

Source :

Movement Disorders [ 0885-3185 ] ; 2011.

RBID : PMC:3261329

Abstract

Background

The pathology of essential tremor is increasingly being studied; however, there are limited studies of biochemical changes in this condition.

Methods

We studied several candidate biochemical/anatomical systems in the brainstem, striatum and cerebellum of 23 essential tremor subjects who came to autopsy, comparing them to a control population.

Results

Striatal tyrosine hydroxylase, a marker of dopaminergic neurons, was 91.7 ±113.2 ng/mg versus 96.4±102.7 ng/mg (not significant) in cases and controls. Locus ceruleus dopamine beta-hydroxylase, a marker of noradrenergic neurons, was not significantly different between essential tremor and control groups. Parvalbumin, a marker of GABAergic neurons, was 199.3±42.0 versus 251.4±74.8 ng/mg (p=0.025) in the pons in the region of the locus ceruleus of essential tremor versus controls, while there was no difference in cerebellar parvalbumin.

Conclusion

These results are supportive of a possible role for reduced GABAergic function within the locus ceruleus in essential tremor. The hypothesis that essential tremor represents early Parkinson’s disease was not supported as striatal dopaminergic markers were not reduced compared to control subjects.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261329

DOI: 10.1002/mds.24004
PubMed: 22038525
PubMed Central: 3261329

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<author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A." last="Shill">Holly A. Shill</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H." last="Adler">Charles H. Adler</name>
<affiliation><nlm:aff id="A2">Mayo Clinic Arizona</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
</affiliation>
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<author><name sortKey="Lue, Lih Fen" sort="Lue, Lih Fen" uniqKey="Lue L" first="Lih-Fen" last="Lue">Lih-Fen Lue</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Caviness, John N" sort="Caviness, John N" uniqKey="Caviness J" first="John N." last="Caviness">John N. Caviness</name>
<affiliation><nlm:aff id="A2">Mayo Clinic Arizona</nlm:aff>
</affiliation>
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<author><name sortKey="Sabbagh, Marwan N" sort="Sabbagh, Marwan N" uniqKey="Sabbagh M" first="Marwan N." last="Sabbagh">Marwan N. Sabbagh</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sue, Lucia I" sort="Sue, Lucia I" uniqKey="Sue L" first="Lucia I" last="Sue">Lucia I. Sue</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Walker, Douglas G" sort="Walker, Douglas G" uniqKey="Walker D" first="Douglas G." last="Walker">Douglas G. Walker</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Brain biochemistry in autopsied patients with essential tremor</title>
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<author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H." last="Adler">Charles H. Adler</name>
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<author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name>
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</affiliation>
</author>
<author><name sortKey="Lue, Lih Fen" sort="Lue, Lih Fen" uniqKey="Lue L" first="Lih-Fen" last="Lue">Lih-Fen Lue</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Caviness, John N" sort="Caviness, John N" uniqKey="Caviness J" first="John N." last="Caviness">John N. Caviness</name>
<affiliation><nlm:aff id="A2">Mayo Clinic Arizona</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sabbagh, Marwan N" sort="Sabbagh, Marwan N" uniqKey="Sabbagh M" first="Marwan N." last="Sabbagh">Marwan N. Sabbagh</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sue, Lucia I" sort="Sue, Lucia I" uniqKey="Sue L" first="Lucia I" last="Sue">Lucia I. Sue</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Walker, Douglas G" sort="Walker, Douglas G" uniqKey="Walker D" first="Douglas G." last="Walker">Douglas G. Walker</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
</affiliation>
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<series><title level="j">Movement Disorders</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">The pathology of essential tremor is increasingly being studied; however, there are limited studies of biochemical changes in this condition.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">We studied several candidate biochemical/anatomical systems in the brainstem, striatum and cerebellum of 23 essential tremor subjects who came to autopsy, comparing them to a control population.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Striatal tyrosine hydroxylase, a marker of dopaminergic neurons, was 91.7 ±113.2 ng/mg versus 96.4±102.7 ng/mg (not significant) in cases and controls. Locus ceruleus dopamine beta-hydroxylase, a marker of noradrenergic neurons, was not significantly different between essential tremor and control groups. Parvalbumin, a marker of GABAergic neurons, was 199.3±42.0 versus 251.4±74.8 ng/mg (p=0.025) in the pons in the region of the locus ceruleus of essential tremor versus controls, while there was no difference in cerebellar parvalbumin.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">These results are supportive of a possible role for reduced GABAergic function within the locus ceruleus in essential tremor. The hypothesis that essential tremor represents early Parkinson’s disease was not supported as striatal dopaminergic markers were not reduced compared to control subjects.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
<journal-title-group><journal-title>Movement Disorders</journal-title>
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<issn pub-type="ppub">0885-3185</issn>
<issn pub-type="epub">1531-8257</issn>
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<article-meta><article-id pub-id-type="pmid">22038525</article-id>
<article-id pub-id-type="pmc">3261329</article-id>
<article-id pub-id-type="doi">10.1002/mds.24004</article-id>
<article-id pub-id-type="manuscript">NIHMS327532</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Brain biochemistry in autopsied patients with essential tremor</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Shill</surname>
<given-names>Holly A.</given-names>
</name>
<degrees>MD</degrees>
<xref rid="A1" ref-type="aff">1</xref>
<email>Holly.shill@bannerhealth.com</email>
</contrib>
<contrib contrib-type="author"><name><surname>Adler</surname>
<given-names>Charles H.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref rid="A2" ref-type="aff">2</xref>
<email>cadler@mayo.edu</email>
</contrib>
<contrib contrib-type="author"><name><surname>Beach</surname>
<given-names>Thomas G</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref rid="A1" ref-type="aff">1</xref>
<email>Thomas.beach@bannerhealth.com</email>
</contrib>
<contrib contrib-type="author"><name><surname>Lue</surname>
<given-names>Lih-Fen</given-names>
</name>
<degrees>PhD</degrees>
<xref rid="A1" ref-type="aff">1</xref>
<email>Lihfen.lue@bannerhealth.com</email>
</contrib>
<contrib contrib-type="author"><name><surname>Caviness</surname>
<given-names>John N.</given-names>
</name>
<degrees>MD</degrees>
<xref rid="A2" ref-type="aff">2</xref>
<email>jcaviness@mayo.edu</email>
</contrib>
<contrib contrib-type="author"><name><surname>Sabbagh</surname>
<given-names>Marwan N.</given-names>
</name>
<degrees>MD</degrees>
<xref rid="A1" ref-type="aff">1</xref>
<email>Marwan.sabbagh@bannerhealth.com</email>
</contrib>
<contrib contrib-type="author"><name><surname>Sue</surname>
<given-names>Lucia I</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
<email>Lucia.sue@bannerhealth.com</email>
</contrib>
<contrib contrib-type="author"><name><surname>Walker</surname>
<given-names>Douglas G.</given-names>
</name>
<degrees>PhD</degrees>
<xref rid="A1" ref-type="aff">1</xref>
<email>Douglas.walker@bannerhealth.com</email>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Banner Sun Health Research Institute</aff>
<aff id="A2"><label>2</label>
Mayo Clinic Arizona</aff>
<author-notes><corresp id="FN1">Correspondence to: Holly Shill MD, Director, Christopher Center for Parkinson Research, 10515 W. Santa Fe Dr., Sun City, AZ 85351, Phone: (623) 875-6500, Fax: (623) 875-6504, <email>holly.shill@bannerhealth.com</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>7</day>
<month>10</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>28</day>
<month>10</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><month>1</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>1</month>
<year>2013</year>
</pub-date>
<volume>27</volume>
<issue>1</issue>
<fpage>113</fpage>
<lpage>117</lpage>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">The pathology of essential tremor is increasingly being studied; however, there are limited studies of biochemical changes in this condition.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">We studied several candidate biochemical/anatomical systems in the brainstem, striatum and cerebellum of 23 essential tremor subjects who came to autopsy, comparing them to a control population.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Striatal tyrosine hydroxylase, a marker of dopaminergic neurons, was 91.7 ±113.2 ng/mg versus 96.4±102.7 ng/mg (not significant) in cases and controls. Locus ceruleus dopamine beta-hydroxylase, a marker of noradrenergic neurons, was not significantly different between essential tremor and control groups. Parvalbumin, a marker of GABAergic neurons, was 199.3±42.0 versus 251.4±74.8 ng/mg (p=0.025) in the pons in the region of the locus ceruleus of essential tremor versus controls, while there was no difference in cerebellar parvalbumin.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">These results are supportive of a possible role for reduced GABAergic function within the locus ceruleus in essential tremor. The hypothesis that essential tremor represents early Parkinson’s disease was not supported as striatal dopaminergic markers were not reduced compared to control subjects.</p>
</sec>
</abstract>
<kwd-group><title>Search terms</title>
<kwd>tremor</kwd>
<kwd>pathology</kwd>
<kwd>GABA</kwd>
<kwd>norepinephrine</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute on Aging  : NIA</funding-source>
<award-id>P30 AG019610-05 || AG</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Brain biochemistry in autopsied patients with essential tremor

Brain biochemistry in autopsied patients with essential tremor

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Abstract

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