Hippocampal, Caudate, and Ventricular Changes in Parkinson’s Disease with and Without Dementia
Identifieur interne : 000089 ( Pmc/Curation ); précédent : 000088; suivant : 000090Hippocampal, Caudate, and Ventricular Changes in Parkinson’s Disease with and Without Dementia
Auteurs : Liana G. Apostolova [États-Unis] ; Mona Beyer [Norvège] ; Amity E. Green [États-Unis] ; Kristy S. Hwang [États-Unis] ; Jonathan H. Morra [États-Unis] ; Yi-Yu Chou [États-Unis] ; Christina Avedissian [États-Unis] ; Dag Aarsland [Norvège] ; Carmen C. Janvin [Norvège] ; Jan P. Larsen [Norvège] ; Jeffrey L. Cummings [États-Unis] ; Paul M. Thompson [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
Abstract
Parkinson’s disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson’s Disease Rating Scale (UPDRS) Part III:motor subscale and Mini-Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend-level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between-group differences in radial distance ranged between 20–30% for caudate and 5–20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend-level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement.
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DOI: 10.1002/mds.22799
PubMed: 20437538
PubMed Central: 3068920
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Apostolova</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation></author><author><name sortKey="Beyer, Mona" sort="Beyer, Mona" uniqKey="Beyer M" first="Mona" last="Beyer">Mona Beyer</name><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Radiology, Stavanger University Hospital, Stavanger, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Radiology, Stavanger University Hospital, Stavanger</wicri:regionArea></affiliation></author><author><name sortKey="Green, Amity E" sort="Green, Amity E" uniqKey="Green A" first="Amity E." last="Green">Amity E. 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Thompson</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20437538</idno><idno type="pmc">3068920</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068920</idno><idno type="RBID">PMC:3068920</idno><idno type="doi">10.1002/mds.22799</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000089</idno><idno type="wicri:Area/Pmc/Curation">000089</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hippocampal, Caudate, and Ventricular Changes in Parkinson’s Disease with and Without Dementia</title><author><name sortKey="Apostolova, Liana G" sort="Apostolova, Liana G" uniqKey="Apostolova L" first="Liana G." last="Apostolova">Liana G. Apostolova</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation></author><author><name sortKey="Beyer, Mona" sort="Beyer, Mona" uniqKey="Beyer M" first="Mona" last="Beyer">Mona Beyer</name><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Radiology, Stavanger University Hospital, Stavanger, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Radiology, Stavanger University Hospital, Stavanger</wicri:regionArea></affiliation></author><author><name sortKey="Green, Amity E" sort="Green, Amity E" uniqKey="Green A" first="Amity E." last="Green">Amity E. Green</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation></author><author><name sortKey="Hwang, Kristy S" sort="Hwang, Kristy S" uniqKey="Hwang K" first="Kristy S." last="Hwang">Kristy S. Hwang</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation></author><author><name sortKey="Morra, Jonathan H" sort="Morra, Jonathan H" uniqKey="Morra J" first="Jonathan H." last="Morra">Jonathan H. Morra</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation></author><author><name sortKey="Chou, Yi Yu" sort="Chou, Yi Yu" uniqKey="Chou Y" first="Yi-Yu" last="Chou">Yi-Yu Chou</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation></author><author><name sortKey="Avedissian, Christina" sort="Avedissian, Christina" uniqKey="Avedissian C" first="Christina" last="Avedissian">Christina Avedissian</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><affiliation wicri:level="1"><nlm:aff id="A4"> Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger</wicri:regionArea></affiliation></author><author><name sortKey="Janvin, Carmen C" sort="Janvin, Carmen C" uniqKey="Janvin C" first="Carmen C." last="Janvin">Carmen C. Janvin</name><affiliation wicri:level="1"><nlm:aff id="A4"> Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger</wicri:regionArea></affiliation></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P." last="Larsen">Jan P. Larsen</name><affiliation wicri:level="1"><nlm:aff id="A5"> Department of Neurology, Stavanger University Hospital, Stavanger, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Neurology, Stavanger University Hospital, Stavanger</wicri:regionArea></affiliation></author><author><name sortKey="Cummings, Jeffrey L" sort="Cummings, Jeffrey L" uniqKey="Cummings J" first="Jeffrey L." last="Cummings">Jeffrey L. Cummings</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6"> Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Parkinson’s disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson’s Disease Rating Scale (UPDRS) Part III:motor subscale and Mini-Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend-level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between-group differences in radial distance ranged between 20–30% for caudate and 5–20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend-level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20437538</article-id><article-id pub-id-type="pmc">3068920</article-id><article-id pub-id-type="doi">10.1002/mds.22799</article-id><article-id pub-id-type="manuscript">NIHMS278106</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Hippocampal, Caudate, and Ventricular Changes in Parkinson’s Disease with and Without Dementia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Apostolova</surname><given-names>Liana G.</given-names></name><degrees>MD</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Beyer</surname><given-names>Mona</given-names></name><degrees>MD, PhD</degrees><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Green</surname><given-names>Amity E.</given-names></name><degrees>BS</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Hwang</surname><given-names>Kristy S.</given-names></name><degrees>BS</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Morra</surname><given-names>Jonathan H.</given-names></name><degrees>PhD</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Chou</surname><given-names>Yi-Yu</given-names></name><degrees>MS</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Avedissian</surname><given-names>Christina</given-names></name><degrees>BS</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Aarsland</surname><given-names>Dag</given-names></name><degrees>MD, PhD</degrees><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Janvin</surname><given-names>Carmen C.</given-names></name><degrees>PhD</degrees><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Larsen</surname><given-names>Jan P.</given-names></name><degrees>MD, PhD</degrees><xref rid="A5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Cummings</surname><given-names>Jeffrey L.</given-names></name><degrees>MD</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Thompson</surname><given-names>Paul M.</given-names></name><degrees>PhD</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref></contrib></contrib-group><aff id="A1"><label>1</label> Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</aff><aff id="A2"><label>2</label> Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</aff><aff id="A3"><label>3</label> Department of Radiology, Stavanger University Hospital, Stavanger, Norway</aff><aff id="A4"><label>4</label> Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</aff><aff id="A5"><label>5</label> Department of Neurology, Stavanger University Hospital, Stavanger, Norway</aff><aff id="A6"><label>6</label> Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, California, USA</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence to: Liana G. Apostolova, Mary S. Easton Center Alzheimer’s Disease Center, 10911 Weyburn Ave, 2nd floor, Los Angeles, CA 90095., <email>lapostolova@mednet.ucla.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>15</day><month>3</month><year>2011</year></pub-date><pub-date pub-type="ppub"><day>30</day><month>4</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>31</day><month>3</month><year>2011</year></pub-date><volume>25</volume><issue>6</issue><fpage>687</fpage><lpage>688</lpage><abstract><p id="P1">Parkinson’s disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson’s Disease Rating Scale (UPDRS) Part III:motor subscale and Mini-Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend-level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between-group differences in radial distance ranged between 20–30% for caudate and 5–20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend-level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement.</p></abstract><kwd-group><kwd>Parkinson disease dementia (PDD)</kwd><kwd>mild cognitive impairment (MCI)</kwd><kwd>hippocampal atrophy</kwd><kwd>caudate atrophy</kwd><kwd>ventricular enlargement</kwd></kwd-group><contract-num rid="AG1">P50 AG016570-11A1
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