Parkinsonism in patients with a history of amphetamine exposure
Identifieur interne : 000076 ( Pmc/Curation ); précédent : 000075; suivant : 000077Parkinsonism in patients with a history of amphetamine exposure
Auteurs : Chadwick W. Christine [États-Unis] ; Elisabeth R. Garwood ; Lauren E. Schrock ; Daniel E. Austin ; Charles E. Mcculloch [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
Abstract
We recently found a higher rate of prolonged amphetamine exposure in patients diagnosed with Parkinson's disease (PD) than in spouse/caregiver controls. Since distinguishing features have been described in some patients with parkinsonism due to environment exposures (e.g. manganese), we sought to compare the clinical features of PD patients with
Url:
DOI: 10.1002/mds.22915
PubMed: 20063432
PubMed Central: 2831101
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Lauren E. Schrock<affiliation><nlm:aff id="A3">Department of Neurology, University of Utah</nlm:aff>
<wicri:noCountry code="subfield">University of Utah</wicri:noCountry>
</affiliation>
Le document en format XML
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<author><name sortKey="Christine, Chadwick W" sort="Christine, Chadwick W" uniqKey="Christine C" first="Chadwick W." last="Christine">Chadwick W. Christine</name>
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<author><name sortKey="Garwood, Elisabeth R" sort="Garwood, Elisabeth R" uniqKey="Garwood E" first="Elisabeth R." last="Garwood">Elisabeth R. Garwood</name>
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<author><name sortKey="Austin, Daniel E" sort="Austin, Daniel E" uniqKey="Austin D" first="Daniel E." last="Austin">Daniel E. Austin</name>
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<author><name sortKey="Mcculloch, Charles E" sort="Mcculloch, Charles E" uniqKey="Mcculloch C" first="Charles E." last="Mcculloch">Charles E. Mcculloch</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<front><div type="abstract" xml:lang="en"><p id="P6">We recently found a higher rate of prolonged amphetamine exposure in patients diagnosed with Parkinson's disease (PD) than in spouse/caregiver controls. Since distinguishing features have been described in some patients with parkinsonism due to environment exposures (e.g. manganese), we sought to compare the clinical features of PD patients with <italic>prolonged</italic>
amphetamine exposure with unexposed PD patients. <underline>Prolonged exposure</underline>
was defined as a minimum of twice a week for ≥ 3 months, or weekly use ≥ 1 year. We reviewed the clinical records of patients with PD who had participated in a telephone survey of drug and environmental exposures and compared the clinical features of patients with a history of prolonged amphetamine exposure to patients who had no such exposure. Records were available for 16 of 17 (94%) patients with prior amphetamine exposure and 127 of 137 (92%) of those unexposed. Age at diagnosis was younger in the amphetamine-exposed group (49.8 ± 8.2 years vs. 53.1 ±7.4 years; p < 0.05), but other features, including presenting symptoms, initial and later treatments, development of motor fluctuations, and MRI findings were similar between these groups. Because we did not detect clinical features that differentiate parkinsonism in patients with prolonged amphetamine exposure, research to determine whether amphetamine exposure is a risk factor for parkinsonism will require detailed histories of medication and recreational drug use.</p>
</div>
</front>
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<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
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<journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title>
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<title-group><article-title>Parkinsonism in patients with a history of amphetamine exposure</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Christine</surname>
<given-names>Chadwick W.</given-names>
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<degrees>MD</degrees>
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<contrib contrib-type="author"><name><surname>Garwood</surname>
<given-names>Elisabeth R.</given-names>
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<contrib contrib-type="author"><name><surname>Schrock</surname>
<given-names>Lauren E.</given-names>
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<contrib contrib-type="author"><name><surname>Austin</surname>
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<contrib contrib-type="author"><name><surname>McCulloch</surname>
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<aff id="A1"><label>1</label>
Department of Neurology, University of California, San Francisco</aff>
<aff id="A2"><label>2</label>
Pennsylvania State University College of Medicine</aff>
<aff id="A3"><label>3</label>
Department of Neurology, University of Utah</aff>
<aff id="A4"><label>4</label>
Colby College</aff>
<aff id="A5"><label>5</label>
Department of Epidemiology and Biostatistics University of California, San Francisco</aff>
<author-notes><fn id="FN1"><p id="P1"><bold>Author Roles:</bold>
Chadwick Christine conceived, designed, and organized the study, gathered and analyzed data, and wrote the first draft and final draft of the manuscript.</p>
<p id="P2">Elisabeth Garwood gathered data, performing the statistical analysis, and reviewed and critiqued the manuscript.</p>
<p id="P3">Lauren Schrock helped in the initial design of the study gathered data, and reviewed critiqued a final draft of the manuscript.</p>
<p id="P4">Dan Austin gathered study data and reviewed and critiqued the final draft of the manuscript.</p>
<p id="P5">Charles E. McCulloch was involved in the study design, statistical analysis, and extensively reviewed and critiqued the manuscript.</p>
</fn>
<corresp id="CR1">Corresponding author: Chadwick W. Christine Department of Neurology, UCSF 400 Parnassus Avenue, Box 0348 San Francisco CA 94143 <email>chad.christine@ucsf.edu</email>
phone: 415-353-9046 fax: 415-353-3573 Reprints requests should be sent to Chadwick W. Christine.</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>11</day>
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<pub-date pub-type="pmc-release"><day>30</day>
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<year>2011</year>
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<volume>25</volume>
<issue>2</issue>
<fpage>228</fpage>
<lpage>231</lpage>
<abstract><p id="P6">We recently found a higher rate of prolonged amphetamine exposure in patients diagnosed with Parkinson's disease (PD) than in spouse/caregiver controls. Since distinguishing features have been described in some patients with parkinsonism due to environment exposures (e.g. manganese), we sought to compare the clinical features of PD patients with <italic>prolonged</italic>
amphetamine exposure with unexposed PD patients. <underline>Prolonged exposure</underline>
was defined as a minimum of twice a week for ≥ 3 months, or weekly use ≥ 1 year. We reviewed the clinical records of patients with PD who had participated in a telephone survey of drug and environmental exposures and compared the clinical features of patients with a history of prolonged amphetamine exposure to patients who had no such exposure. Records were available for 16 of 17 (94%) patients with prior amphetamine exposure and 127 of 137 (92%) of those unexposed. Age at diagnosis was younger in the amphetamine-exposed group (49.8 ± 8.2 years vs. 53.1 ±7.4 years; p < 0.05), but other features, including presenting symptoms, initial and later treatments, development of motor fluctuations, and MRI findings were similar between these groups. Because we did not detect clinical features that differentiate parkinsonism in patients with prolonged amphetamine exposure, research to determine whether amphetamine exposure is a risk factor for parkinsonism will require detailed histories of medication and recreational drug use.</p>
</abstract>
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<contract-num rid="NS1">P01 NS044155-06A15206
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