MovDisordV3, Pmc, Curation, bibRecord, 000020

Paroxysmal Dyskinesias in Mice

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Paroxysmal Dyskinesias in Mice

Auteurs : Thomas L. Shirley ; Lekha M. Rao ; Ellen J. Hess ; H. A. Jinnah

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2008.

RBID : PMC:2887756

Abstract

Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887756

DOI: 10.1002/mds.21829
PubMed: 17999434
PubMed Central: 2887756

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PMC:2887756

Le document en format XML

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<author><name sortKey="Shirley, Thomas L" sort="Shirley, Thomas L" uniqKey="Shirley T" first="Thomas L." last="Shirley">Thomas L. Shirley</name>
</author>
<author><name sortKey="Rao, Lekha M" sort="Rao, Lekha M" uniqKey="Rao L" first="Lekha M." last="Rao">Lekha M. Rao</name>
</author>
<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
</author>
<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
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<idno type="doi">10.1002/mds.21829</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Paroxysmal Dyskinesias in Mice</title>
<author><name sortKey="Shirley, Thomas L" sort="Shirley, Thomas L" uniqKey="Shirley T" first="Thomas L." last="Shirley">Thomas L. Shirley</name>
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<author><name sortKey="Rao, Lekha M" sort="Rao, Lekha M" uniqKey="Rao L" first="Lekha M." last="Rao">Lekha M. Rao</name>
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<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
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<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2008">2008</date>
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<front><div type="abstract" xml:lang="en"><p id="P1">Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders.</p>
</div>
</front>
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<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
<journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title>
<issn pub-type="ppub">0885-3185</issn>
<issn pub-type="epub">1531-8257</issn>
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<article-meta><article-id pub-id-type="pmid">17999434</article-id>
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<article-id pub-id-type="doi">10.1002/mds.21829</article-id>
<article-id pub-id-type="manuscript">NIHMS132080</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Paroxysmal Dyskinesias in Mice</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Shirley</surname>
<given-names>Thomas L.</given-names>
</name>
<degrees>PhD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Rao</surname>
<given-names>Lekha M.</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Hess</surname>
<given-names>Ellen J.</given-names>
</name>
<degrees>PhD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Jinnah</surname>
<given-names>H. A.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<aff id="A1">Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</aff>
</contrib-group>
<author-notes><corresp id="FN1"><label>*</label>
Correspondence to: H.A. Jinnah, Meyer 6-181, Johns Hopkins University, Baltimore, MD 21287. E-mail: <email>hjinnah@jhmi.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>17</day>
<month>7</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="ppub"><day>30</day>
<month>1</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>18</day>
<month>6</month>
<year>2010</year>
</pub-date>
<volume>23</volume>
<issue>2</issue>
<fpage>259</fpage>
<lpage>264</lpage>
<abstract><p id="P1">Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders.</p>
</abstract>
<kwd-group><kwd>tottering</kwd>
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<kwd>paroxysmal dyskinesia</kwd>
<kwd>dystonia</kwd>
<kwd>channelopathy</kwd>
</kwd-group>
<contract-num rid="NS1">R21 NS061349-01A2
				||NS</contract-num>
<contract-num rid="NS1">R01 NS040470-08
				||NS</contract-num>
<contract-num rid="NS1">R01 NS033592-12
				||NS</contract-num>
<contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor>
</article-meta>
</front>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Paroxysmal Dyskinesias in Mice

Paroxysmal Dyskinesias in Mice

Source :

Abstract

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