No Evidence for Substrate Accumulation in Parkinson Brains With GBA Mutations
Identifieur interne : 000468 ( Pmc/Corpus ); précédent : 000467; suivant : 000469No Evidence for Substrate Accumulation in Parkinson Brains With GBA Mutations
Auteurs : Matthew E. Gegg ; Lindsay Sweet ; Bing H. Wang ; Lamya S. Shihabuddin ; Sergio Pablo Sardi ; Anthony H. V. SchapiraSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2015.
Abstract
To establish whether Parkinson’s disease (PD) brains previously described to have decreased glucocerebrosidase activity exhibit accumulation of the lysosomal enzyme’s substrate, glucosylceramide, or other changes in lipid composition.
Lipidomic analyses and cholesterol measurements were performed on the putamen (n = 5-7) and cerebellum (n = 7-14) of controls, Parkinson’s disease brains with heterozygote
Total glucosylceramide levels were unchanged in both PD+GBA and sporadic PD brains when compared with controls. No changes in glucosylsphingosine (deacetylated glucosylceramide), sphingomyelin, gangliosides (GM2, GM3), or total cholesterol were observed in either putamen or cerebellum.
This study did not demonstrate glucocerebrosidase substrate accumulation in PD brains with heterozygote
Url:
DOI: 10.1002/mds.26278
PubMed: 26096906
PubMed Central: 4529481
Links to Exploration step
PMC:4529481***** Acces problem to record *****\Le document en format XML
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000468 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000468 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Pmc |étape= Corpus |type= RBID |clé= PMC:4529481 |texte= No Evidence for Substrate Accumulation in Parkinson Brains With GBA Mutations }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:26096906" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
![]() | This area was generated with Dilib version V0.6.23. | ![]() |