Cerebrospinal Fluid Lysosomal Enzymes and Alpha-Synuclein in Parkinson's Disease
Identifieur interne : 000438 ( Pmc/Corpus ); précédent : 000437; suivant : 000439Cerebrospinal Fluid Lysosomal Enzymes and Alpha-Synuclein in Parkinson's Disease
Auteurs : Lucilla Parnetti ; Davide Chiasserini ; Emanuele Persichetti ; Paolo Eusebi ; Shiji Varghese ; Mohammad M. Qureshi ; Andrea Dardis ; Marta Deganuto ; Claudia De Carlo ; Anna Castrioto ; Chiara Balducci ; Silvia Paciotti ; Nicola Tambasco ; Bruno Bembi ; Laura Bonanni ; Marco Onofrj ; Aroldo Rossi ; Tommaso Beccari ; Omar El-Agnaf ; Paolo CalabresiSource :
- Movement Disorders [ 0885-3185 ] ; 2014.
Abstract
To assess the discriminating power of multiple cerebrospinal fluid (CSF) biomarkers for Parkinson's disease (PD), we measured several proteins playing an important role in the disease pathogenesis. The activities of β-glucocerebrosidase and other lysosomal enzymes, together with total and oligomeric α-synuclein, and total and phosphorylated tau, were thus assessed in CSF of 71 PD patients and compared to 45 neurological controls. Activities of β-glucocerebrosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase were measured with established enzymatic assays, while α-synuclein and tau biomarkers were evaluated with immunoassays. A subset of PD patients (n = 44) was also screened for mutations in the β-glucocerebrosidase-encoding gene (
Url:
DOI: 10.1002/mds.25772
PubMed: 24436092
PubMed Central: 4282452
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