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Movement Disorders (revue)

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Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson’s disease

Identifieur interne : 000385 ( Pmc/Corpus ); précédent : 000384; suivant : 000386

Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson’s disease

Auteurs : Eun-Young Lee ; Paul J. Eslinger ; Guangwei Du ; Lan Kong ; Mechelle M. Lewis ; Xuemei Huang

Source :

RBID : PMC:4116478

Abstract

Background

Olfactory dysfunction is often associated with Parkinson’s disease (PD) and can precede characteristic motor symptoms by several years. Olfactory-related cortical atrophy has been reported in PD, although the extent and association between cortical atrophy and olfactory dysfunction have been controversial. The present study examined whether olfactory dysfunction is associated with gray matter (GM) volume in brain regions subserving primary and secondary olfactory processing.

Methods

High-resolution T1-weighted brain magnetic resonance images were acquired from 40 PD without dementia and 40 matched Controls along with smell identification scores. Brain volumes were compared using voxel-based morphometry (VBM).

Results

Compared to Controls, PD patients sustained greater GM loss localized to bilateral piriform cortex (PC) and orbitofrontal cortex (OFC). Reduced olfactory performance in PD was significantly associated with lower GM volumes in PC and OFC.

Conclusions

Both primary and secondary olfactory cortical atrophy occurred in PD and were associated with olfactory dysfunction.


Url:
DOI: 10.1002/mds.25829
PubMed: 24482154
PubMed Central: 4116478

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