Executive Functions in Premanifest Huntington’s Disease
Identifieur interne : 000376 ( Pmc/Corpus ); précédent : 000375; suivant : 000377Executive Functions in Premanifest Huntington’s Disease
Auteurs : S. Christine You ; Michael D. Geschwind ; Sharon J. Sha ; Alexandra Apple ; Gabriella Satris ; Kristie A. Wood ; Erica T. Johnson ; Jonathan Gooblar ; Jeanne S. Feuerstein ; Steven Finkbeiner ; Gail A. Kang ; Bruce L. Miller ; Christopher P. Hess ; Joel H. Kramer ; Katherine L. PossinSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
Abstract
We investigated the viability of psychometrically robust executive function measures as markers for premanifest Huntington’s disease (HD).
Fifteen premanifest HD subjects and 42 controls were compared on the NIH EXAMINER executive function battery. This battery yields an overall Executive Composite score, plus Working Memory, Cognitive Control, and Fluency Scores that are measured on psychometrically matched scales. The scores were correlated with two disease markers, disease burden and striatal volumes, in the premanifest HD subjects.
The premanifest HD subjects scored significantly lower on the Working Memory Score. The Executive Composite positively correlated with striatal volumes, and Working Memory Score negatively correlated with disease burden. The Cognitive Control and Fluency Scores did not differ between the groups or correlate significantly with the disease markers.
The NIH EXAMINER Executive Composite and Working Memory Score are sensitive markers of cognitive dysfunction, striatal volume, and disease burden in premanifest HD.
Url:
DOI: 10.1002/mds.25762
PubMed: 24375511
PubMed Central: 4029327
Links to Exploration step
PMC:4029327***** Acces problem to record *****\Le document en format XML
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000376 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000376 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:4029327
|texte= Executive Functions in Premanifest Huntington’s Disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:24375511" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |