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Movement Disorders (revue)

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Malignant Melanoma in Early-Treated Parkinson's Disease: The NET-PD Trial

Identifieur interne : 000374 ( Pmc/Corpus ); précédent : 000373; suivant : 000375

Malignant Melanoma in Early-Treated Parkinson's Disease: The NET-PD Trial

Auteurs : Radu Constantinescu ; Jordan Elm ; Peggy Auinger ; Saloni Sharma ; Erika F. Augustine ; Laith Khadim ; Karl Kieburtz

Source :

RBID : PMC:4375545

Abstract

Background

The risk for malignant melanoma is higher than expected in Parkinson's disease (PD). The National Institutes of Health (NIH) Exploratory Trials in PD (NET-PD) Long-term Study 1 (LS-1) trial is a contemporary phase 3 study of subjects with early, treated PD. The objective of this work was to assess the incidence of malignant melanoma in a PD cohort.

Methods

Incident melanoma cases were identified from the adverse events log. The expected number of cases was calculated, using the expected incidence rates and the number of person-years.

Results

A total of 618 females and 1119 males were followed for 6452 person-years; 19 new melanoma cases were observed. The expected number was 5.29. The standardized event ratio compared to the general population was 3.6 (95% confidence interval, 2.2-5.6).

Conclusions

The risk for developing melanoma was higher than expected in the NET-PD LS-1 cohort and was similar to the risk reported in earlier comparable clinical trial cohorts. Dermatologic screening may be useful in Parkinson's disease to identify melanoma at an early stage.


Url:
DOI: 10.1002/mds.25734
PubMed: 24323565
PubMed Central: 4375545

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