The effect of expectancy and personality on cortical excitability in Parkinson’s disease
Identifieur interne : 000324 ( Pmc/Corpus ); précédent : 000323; suivant : 000325The effect of expectancy and personality on cortical excitability in Parkinson’s disease
Auteurs : Jau-Shin Lou ; Diana M. Dimitrova ; Richard Hammerschlag ; John Nutt ; Elizabeth A. Hunt ; Ryan W. Eaton ; Sarah C. Johnson ; Melanie D. Davis ; Grace C. Arnold ; Sarah B. Andrea ; Barry S. OkenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
Abstract
Our previous studies in PD have shown that both levodopa and expectancy of receiving levodopa reduce cortical excitability. We designed this study to evaluate how degree of expectancy and other individual factors modulate placebo response in Parkinson’s patients.
Twenty-six Parkinson’s patients were randomized to one of three groups: 0%, 50% and 100% expectancy of receiving levodopa. All subjects received placebo regardless of expectancy group. Subjects completed the NEO-Five Factor Inventory, General Perceived Self-Efficacy Scale, and Perceived Stress Scale. Cortical excitability was measured by the amplitude of motor evoked potential (MEP) evoked by transcranial magnetic stimulation. Objective physical fatigue of
Degree of expectancy had a significant effect on MEP response (p<0.05). Subjects in the 50% and 100% expectancy groups responded with a decrease in MEP, while those in the 0% expectancy group responded with an increase in MEP (p<0.05). Responders tended to be more open to experience than non-responders. There were no significant changes in objective physical fatigue between the expectancy groups, or between responders and non-responders.
Expectancy is associated with changes in cortical excitability. Further studies are needed to examine the relationship between personality and placebo effect in Parkinson’s patients.
Url:
DOI: 10.1002/mds.25471
PubMed: 23630185
PubMed Central: 3735617
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