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Movement Disorders (revue)

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Caffeine Consumption and Risk of Dyskinesia in CALM-PD

Identifieur interne : 000307 ( Pmc/Corpus ); précédent : 000306; suivant : 000308

Caffeine Consumption and Risk of Dyskinesia in CALM-PD

Auteurs : Anne-Marie A. Wills ; Shirley Eberly ; Marsha Tennis ; Anthony E. Lang ; Susan Messing ; Daniel Togasaki ; Caroline M. Tanner ; Cornelia Kamp ; Jiang-Fan Chen ; David Oakes ; Michael P. Mcdermott ; Michael A. Schwarzschild

Source :

RBID : PMC:3608707

Abstract

Background

Adenosine A2A receptor antagonists reduce or prevent the development of dyskinesia in animal models of levodopa-induced dyskinesia.

Methods

We examined the association between self-reported intake of the A2A receptor antagonist caffeine and time to dyskinesia in the Comparison of the Agonist Pramipexole with Levodopa on Motor Complications of Parkinson’s Disease (CALM-PD) and CALM Cohort extension studies, using a Cox proportional hazards model adjusting for age, baseline Parkinson’s severity, site, and initial treatment with pramipexole or levodopa.

Results

For subjects who consumed > 12 ounces of coffee/day, the adjusted hazard ratio for the development of dyskinesia was 0.61 (95% confidence interval, 0.37–1.01) compared to subjects who consumed < 4 ounces/day. For subjects who consumed between 4 and 12 ounces/day, the adjusted hazard ratio was 0.73 (C.I. 0.46–1.15) (test for trend, p = 0.05).

Conclusions

These results support the possibility that caffeine may reduce the likelihood of developing dyskinesia.


Url:
DOI: 10.1002/mds.25319
PubMed: 23339054
PubMed Central: 3608707

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