Family-Based and Population-Based Association Studies Validate PTPRD as a Risk Factor for Restless Legs Syndrome
Identifieur interne : 000228 ( Pmc/Corpus ); précédent : 000227; suivant : 000229Family-Based and Population-Based Association Studies Validate PTPRD as a Risk Factor for Restless Legs Syndrome
Auteurs : Qinbo Yang ; Lin Li ; Rong Yang ; Gong-Qing Shen ; Qiuyun Chen ; Nancy Foldvary-Schaefer ; William G. Ondo ; Qing Kenneth WangSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2011.
Abstract
We previously mapped a genetic locus for restless legs syndrome (RLS) to chromosome 9p22–24 (
We genotyped two intronic SNPs rs1975197 and rs4626664 in
A family-based sibling transmission disequilibrium test showed association of RLS with SNP rs1975197 (
This represents the first independent study to validate the association between
Url:
DOI: 10.1002/mds.23459
PubMed: 21264940
PubMed Central: 3895410
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