The Role of Parkin in Familial and Sporadic Parkinson’s Disease
Identifieur interne : 000218 ( Pmc/Corpus ); précédent : 000217; suivant : 000219The Role of Parkin in Familial and Sporadic Parkinson’s Disease
Auteurs : Ted M. Dawson ; Valina L. DawsonSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
Abstract
Mutations in Parkin are the second most common known cause of Parkinson’s disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin’s E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here we review parkin biology and pathobiology and its role in the pathogenesis of PD.
Url:
DOI: 10.1002/mds.22798
PubMed: 20187240
PubMed Central: 4115293
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