The Neuropathology of Genetic Parkinson’s Disease
Identifieur interne : 000191 ( Pmc/Corpus ); précédent : 000190; suivant : 000192The Neuropathology of Genetic Parkinson’s Disease
Auteurs : M. Poulopoulos ; Oa Levy ; Rn AlcalaySource :
- Movement Disorders [ 0885-3185 ] ; 2012.
Abstract
Pathological data from autopsies genotyped for PD-related mutations in
A systematic review of the English literature using the terms “Parkinson’s disease”, “brain pathology”, “autopsy”, and the specific gene nomenclature, and any combination of the above.
Most studies included reports of convenience samples, either cases that were pre-identified as mutation carriers before autopsy, or screens of Lewy body brain banks. Nineteen autopsies of
In gathering together all studies of PD autopsies with an identified genetic risk, this review highlights the wealth of information generated, as well as shortcomings in the available data. In particular, there is a need for larger, unbiased pathological studies. Differential association of Lewy pathology with specific mutations may reflect heterogeneity in pathogenic mechanisms among the different PD-related genes.
Url:
DOI: 10.1002/mds.24962
PubMed: 22451330
PubMed Central: 3383342
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