Serum urate and probability of dopaminergic deficit in early ‘Parkinson disease’
Identifieur interne : 000176 ( Pmc/Corpus ); précédent : 000175; suivant : 000177Serum urate and probability of dopaminergic deficit in early ‘Parkinson disease’
Auteurs : Michael A. Schwarzschild ; Kenneth Marek ; Shirley Eberly ; David Oakes ; Ira Shoulson ; Danna Jennings ; John Seibyl ; Alberto AscherioSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2011.
Abstract
Investigate whether higher levels of urate, an antioxidant linked to a lower likelihood of developing Parkinson disease (PD), is also a predictor of having a dopamine transporter brain scan without evidence of dopaminergic deficit (SWEDD).
In a cross-sectional study of 797 mildly affected, untreated parkinsonian subjects diagnosed with early PD in the Parkinson Research Examination of CEP-1347 Trial (PRECEPT), we investigated the relationship at baseline between serum urate and striatal dopamine transporter density, determined by single-photon emission computed-tomography of iodine-123-labeled 2-β-carboxymethoxy-3-β-(4-iodophenyl)tropane ([123I]β-CIT) uptake. A SWEDD was defined as lowest putamen [123I]β-CIT > 80% age-expected putamen DAT density.
Odds of having a SWEDD rose across increasing quintiles of urate level, with an age- and gender-adjusted odds ratio of 3.2 comparing the highest to the lowest urate quintile; 95% CI: 1.5 to 7.2; p for trend = 0.0003) and remained significant after adjusting for potential confounding factors. The association was significant in men but not women, regardless of whether common or sex-specific quintiles of urate were used.
Higher levels of urate were associated with a greater likelihood of a SWEDD amongst subjects with early untreated parkinsonism in the PRECEPT study. The findings support the diagnostic utility of urate in combination with other determinants.
Url:
DOI: 10.1002/mds.23741
PubMed: 21538532
PubMed Central: 3150627
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