Replication of MAPT and SNCA, but not PARK16-18, as Susceptibility Genes for Parkinson’s Disease
Identifieur interne : 000129 ( Pmc/Corpus ); précédent : 000128; suivant : 000130Replication of MAPT and SNCA, but not PARK16-18, as Susceptibility Genes for Parkinson’s Disease
Auteurs : Ignacio F. Mata ; Dora Yearout ; Victoria Alvarez ; Eliecer Coto ; Lorena De Mena ; Renee Ribacoba ; Oswaldo Lorenzo-Betancor ; Lluis Samaranch ; Pau Pastor ; Sebastian Cervantes ; Jon Infante ; Ines Garcia-Gorostiaga ; Maria Sierra ; Onofre Combarros ; Katherine W. Snapinn ; Karen L. Edwards ; Cyrus P. ZabetianSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2011.
Abstract
Recent genome-wide association studies of Parkinson’s disease have nominated three new susceptibility loci (
We genotyped single nucleotide polymorphisms in each of these genes/loci in 1,445 Parkinson’s disease patients and 1,161 controls from Northern Spain. Logistic regression was used to test for association between genotype and Parkinson’s disease under an additive model, adjusting for sex, age, and site. We also performed analyses stratified by age at onset.
Single nucleotide polymorphisms in
While our data further validate
Url:
DOI: 10.1002/mds.23642
PubMed: 21425343
PubMed Central: 3082603
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