Decreased striatal dopamine receptor binding in primary focal dystonia: a D2 or D3 defect?
Identifieur interne : 000122 ( Pmc/Corpus ); précédent : 000121; suivant : 000123Decreased striatal dopamine receptor binding in primary focal dystonia: a D2 or D3 defect?
Auteurs : Morvarid Karimi ; Stephen M. Moerlein ; Tom O. Videen ; Robert R. Luedtke ; Michelle Taylor ; Robert H. Mach ; Joel S. PerlmutterSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
Abstract
Dystonia is an involuntary movement disorder characterized by repetitive patterned or sustained muscle contractions causing twisting or abnormal postures. Several lines of evidence suggest that abnormalities of dopaminergic pathways contribute to the pathophysiology of dystonia. In particular dysfunction of D2-like receptors that mediate function of the indirect pathway in the basal ganglia may play a key role. We have demonstrated with positron emission tomography (PET) that patients with primary focal cranial or hand dystonia have reduced putamenal specific binding of [18F]spiperone a non-selective D2-like radioligand with nearly equal affinity for serotonergic 5-HT(2A) sites. We then repeated the study with [18F]N-methyl-benperidol (NMB), a more selective D2-like receptor radioligand with minimal affinity for 5-HT(2A). Surprisingly, there was no decrease in NMB binding in the putamen of subjects with dystonia. Our findings excluded reductions of putamenal uptake greater than 20% with 95% confidence intervals. Following analysis of the
Url:
DOI: 10.1002/mds.23401
PubMed: 20960437
PubMed Central: 3025272
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