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Movement Disorders (revue)

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FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α-synuclein expression

Identifieur interne : 000047 ( Pmc/Corpus ); précédent : 000046; suivant : 000048

FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α-synuclein expression

Auteurs : Christian Wider ; Justus C. Dachsel ; Alexandra I. Soto ; Michael G. Heckman ; Nancy N. Diehl ; Mei Yue ; Sarah Lincoln ; Jan O. Aasly ; Kristoffer Haugarvoll ; John Q. Trojanowski ; Spiridon Papapetropoulos ; Deborah Mash ; Alex Rajput ; Ali H. Rajput ; J. Mark Gibson ; Timothy Lynch ; Dennis W. Dickson ; Ryan J. Uitti ; Zbigniew K. Wszolek ; Matthew J. Farrer ; Owen A. Ross

Source :

RBID : PMC:2875476

Abstract

Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and α-synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient-control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and α-synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and α-synuclein protein levels.


Url:
DOI: 10.1002/mds.22442
PubMed: 19133659
PubMed Central: 2875476

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