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Atomoxetine for the treatment of executive dysfunction in Parkinson’s disease

Identifieur interne : 000043 ( Pmc/Corpus ); précédent : 000042; suivant : 000044

Atomoxetine for the treatment of executive dysfunction in Parkinson’s disease

Auteurs : Laura Marsh ; Kevin Biglan ; Melissa Gerstenhaber ; James R. Williams

Source :

RBID : PMC:2683743

Abstract

Introduction

Executive dysfunction (ED) is a prominent and often disabling feature of cognitive impairment in Parkinson’s disease (PD). Few studies have examined treatments. Given the role of noradrenergic pathology in ED, atomoxetine, a norepinephrine reuptake inhibitor indicated for attention deficit hyperactivity disorder (ADHD), may be a potential treatment for PD-related ED.

Methods

12 patients with PD and disabling ED completed an 8-week pilot open-label, flexible dose (25 to 100 mg/day) trial of atomoxetine.

Results

On primary outcome measures, atomoxetine was associated with improved ED based on the Clinical Global Impression-Change Scale (75% positive response rate; 95% CI: 43%-95%, p<.05) and behavioral measures of ED [Frontal Systems Behavior Scale (FrSBE) Executive Dysfunction and Connors Adult ADHD Rating Scale (CAARS) inattention/memory subscales]. Adverse effects included sleep and gastrointestinal disturbances and hypomania.

Conclusion

Atomoxetine is tolerable in PD and may benefit clinical manifestations of ED, warranting further study in controlled trials.


Url:
DOI: 10.1002/mds.22307
PubMed: 19025777
PubMed Central: 2683743

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