Clinical Correlates of Depressive Symptoms in Familial Parkinson's Disease
Identifieur interne : 000036 ( Pmc/Corpus ); précédent : 000035; suivant : 000037Clinical Correlates of Depressive Symptoms in Familial Parkinson's Disease
Auteurs : Nathan Pankratz ; Karen S. Marder ; Cheryl A. Halter ; Alice Rudolph ; Cliff W. Shults ; William C. Nichols ; Tatiana ForoudSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2008.
Abstract
Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini-Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (
Url:
DOI: 10.1002/mds.22285
PubMed: 18785635
PubMed Central: 2872794
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