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Effects of a NR2B Selective NMDA Glutamate Antagonist, CP-101,606, on Dyskinesia and Parkinsonism

Identifieur interne : 000012 ( Pmc/Corpus ); précédent : 000011; suivant : 000013

Effects of a NR2B Selective NMDA Glutamate Antagonist, CP-101,606, on Dyskinesia and Parkinsonism

Auteurs : John G. Nutt ; Steven A. Gunzler ; Trish Kirchhoff ; Penelope Hogarth ; Jerry L. Weaver ; Michael Krams ; Brenda Jamerson ; Frank S. Menniti ; Jaren W. Landen

Source :

RBID : PMC:3390310

Abstract

Glutamate antagonists decrease dyskinesia and augment the antiparkinsonian effects of levodopa in animal models of Parkinson’s disease (PD). In a randomized, double-blind, placebo-controlled clinical trial we investigated the acute effects of placebo and two doses of a NR2B subunit selective NMDA glutamate antagonist, CP-101,606, on the response to two-hour levodopa infusions in 12 PD subjects with motor fluctuations and dyskinesia. Both doses of CP-101,606 reduced the maximum severity of levodopa-induced dyskinesia approximately 30% but neither dose improved parkinsonism. CP-101,606 was associated with a dose-related dissociation and amnesia. These results support the hypothesis that glutamate antagonists may be useful antidyskinetic agents. However, future studies will have to determine if the benefits of dyskinesia suppression can be achieved without adverse cognitive effects.


Url:
DOI: 10.1002/mds.22169
PubMed: 18759356
PubMed Central: 3390310

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