MovDisordV3, Pmc, Checkpoint, bibRecord, 000451

Clinical Correlates of Depressive Symptoms in Familial Parkinson's Disease

Identifieur interne : 000451 ( Pmc/Checkpoint ); précédent : 000450; suivant : 000452

Clinical Correlates of Depressive Symptoms in Familial Parkinson's Disease

Auteurs : Nathan Pankratz [États-Unis] ; Karen S. Marder [États-Unis] ; Cheryl A. Halter [États-Unis] ; Alice Rudolph [États-Unis] ; Cliff W. Shults [États-Unis] ; William C. Nichols [États-Unis] ; Tatiana Foroud [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2008.

RBID : PMC:2872794

Abstract

Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini-Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (parkin, LRRK2, APOE). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R² = 0.33; P = 4 × 10⁻⁴⁸). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872794

DOI: 10.1002/mds.22285
PubMed: 18785635
PubMed Central: 2872794

Affiliations:

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Le document en format XML

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<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</nlm:aff>
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<wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana</wicri:regionArea>
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<author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical Correlates of Depressive Symptoms in Familial Parkinson's Disease</title>
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<affiliation wicri:level="2"><nlm:aff id="A7">Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA</nlm:aff>
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<author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini-Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (<italic>parkin, LRRK2, APOE</italic>
). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R<sup>2</sup>
 = 0.33; <italic>P</italic>
 = 4 × 10<sup>−48</sup>
). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms.</p>
</div>
</front>
</TEI>
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  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
<journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title>
<issn pub-type="ppub">0885-3185</issn>
<issn pub-type="epub">1531-8257</issn>
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<article-id pub-id-type="doi">10.1002/mds.22285</article-id>
<article-id pub-id-type="manuscript">NIHMS201831</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Clinical Correlates of Depressive Symptoms in Familial Parkinson's Disease</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Pankratz</surname>
<given-names>Nathan</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Marder</surname>
<given-names>Karen S.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Halter</surname>
<given-names>Cheryl A.</given-names>
</name>
<degrees>MS</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rudolph</surname>
<given-names>Alice</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shults</surname>
<given-names>Cliff W.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nichols</surname>
<given-names>William C.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Foroud</surname>
<given-names>Tatiana</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><collab>the Parkinson's Study Group – PROGENI Investigators</collab>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</aff>
<aff id="A2"><label>2</label>
Department of Neurology, Columbia University and The Taub Institute, New York, USA</aff>
<aff id="A3"><label>3</label>
Department of Neurology, University of Rochester, Rochester, New York, USA</aff>
<aff id="A4"><label>4</label>
Department of Neurology, University of California, San Diego, La Jolla, California, USA</aff>
<aff id="A5"><label>5</label>
VA San Diego Healthcare System, San Diego, California, USA</aff>
<aff id="A6"><label>6</label>
Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</aff>
<aff id="A7"><label>7</label>
Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA</aff>
<author-notes><corresp id="CR1"><label>*</label>
Correspondence to: Dr. Nathan Pankratz, Medical and Molecular Genetics, Indiana University, School of Medicine, Hereditary Genomics Division, 410 West 10th Street, MI-4000, Indianapolis, Indiana 46202. <email>npankrat@iupui.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>11</day>
<month>5</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><day>15</day>
<month>11</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>19</day>
<month>5</month>
<year>2010</year>
</pub-date>
<volume>23</volume>
<issue>15</issue>
<fpage>2216</fpage>
<lpage>2223</lpage>
<permissions><copyright-statement>© 2008 Movement Disorder Society</copyright-statement>
<copyright-year>2008</copyright-year>
</permissions>
<abstract><p id="P1">Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini-Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (<italic>parkin, LRRK2, APOE</italic>
). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R<sup>2</sup>
 = 0.33; <italic>P</italic>
 = 4 × 10<sup>−48</sup>
). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms.</p>
</abstract>
<kwd-group><kwd>Parkinson's disease</kwd>
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<kwd>Hoehn and Yahr stage</kwd>
<kwd>association</kwd>
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</kwd-group>
<contract-num rid="NS1">R01 NS037167-10
				||NS</contract-num>
<contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor>
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</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
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<region><li>Californie</li>
<li>Indiana</li>
<li>Ohio</li>
<li>État de New York</li>
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<tree><country name="États-Unis"><region name="Indiana"><name sortKey="Pankratz, Nathan" sort="Pankratz, Nathan" uniqKey="Pankratz N" first="Nathan" last="Pankratz">Nathan Pankratz</name>
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<name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
<name sortKey="Halter, Cheryl A" sort="Halter, Cheryl A" uniqKey="Halter C" first="Cheryl A." last="Halter">Cheryl A. Halter</name>
<name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S." last="Marder">Karen S. Marder</name>
<name sortKey="Nichols, William C" sort="Nichols, William C" uniqKey="Nichols W" first="William C." last="Nichols">William C. Nichols</name>
<name sortKey="Nichols, William C" sort="Nichols, William C" uniqKey="Nichols W" first="William C." last="Nichols">William C. Nichols</name>
<name sortKey="Rudolph, Alice" sort="Rudolph, Alice" uniqKey="Rudolph A" first="Alice" last="Rudolph">Alice Rudolph</name>
<name sortKey="Shults, Cliff W" sort="Shults, Cliff W" uniqKey="Shults C" first="Cliff W." last="Shults">Cliff W. Shults</name>
<name sortKey="Shults, Cliff W" sort="Shults, Cliff W" uniqKey="Shults C" first="Cliff W." last="Shults">Cliff W. Shults</name>
</country>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Clinical Correlates of Depressive Symptoms in Familial Parkinson's Disease

Clinical Correlates of Depressive Symptoms in Familial Parkinson's Disease

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Abstract

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