Telomere length and risk of Parkinson’s disease
Identifieur interne : 000428 ( Pmc/Checkpoint ); précédent : 000427; suivant : 000429Telomere length and risk of Parkinson’s disease
Auteurs : Hao Wang ; Honglei Chen ; Xiang Gao ; Monica Mcgrath ; Dwayne Deer ; Immaculata De Vivo ; Michael A. Schwarzschild ; Alberto AscherioSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2008.
Abstract
We investigated whether telomere length was associated with the risk of Parkinson’s disease (PD) in a case-control study (96 cases and 172 age-matched controls) nested within the Health Professionals Follow-up Study. Relative ratio of telomere repeat copy number to single-gene copy number in peripheral blood leukocytes was determined by quantitative real time PCR. Men with shorter telomeres had a lower PD risk (multivariate adjusted relative risk for the lowest vs. the highest quartile 0.33; 95% confidence interval: 0.12–0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD.
Url:
DOI: 10.1002/mds.21867
PubMed: 18044760
PubMed Central: 2387100
Affiliations:
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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18044760</article-id><article-id pub-id-type="pmc">2387100</article-id><article-id pub-id-type="doi">10.1002/mds.21867</article-id><article-id pub-id-type="manuscript">NIHMS44546</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Telomere length and risk of Parkinson’s disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Hao</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Honglei</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Xiang</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>McGrath</surname><given-names>Monica</given-names></name><degrees>ScD</degrees></contrib><contrib contrib-type="author"><name><surname>Deer</surname><given-names>Dwayne</given-names></name><degrees>BS</degrees></contrib><contrib contrib-type="author"><name><surname>De Vivo</surname><given-names>Immaculata</given-names></name><degrees>PhD, MPH</degrees></contrib><contrib contrib-type="author"><name><surname>Schwarzschild</surname><given-names>Michael A.</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Ascherio</surname><given-names>Alberto</given-names></name><degrees>MD, DrPH</degrees></contrib><aff id="A1">Department of Nutrition (Dr. Wang, Dr. Gao, Dr. Ascherio) and Epidemiology (Dr. McGrath, Dr. De Vivo, Dr. Ascherio), Program in Molecular and Genetic Epidemiology (Dr. McGrath, Mr. Deer, Dr. De Vivo), Harvard School of Public Health, Boston, Massachusetts; Epidemiology Branch (Dr. Chen), National Institute of Environmental Health Sciences, Research Triangle Park, NC; Channing Laboratory (Dr. McGrath, Mr. Deer, Dr. De Vivo), Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology (Dr. Schwarzschild), Massachusetts General Hospital, Boston, Massachusetts;</aff></contrib-group><author-notes><corresp id="FN1">Corresponding Author and Reprints: Hao Wang, MD, PhD, Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115. Tel. (617) 432-1839; Fax: (617) 432-2435; Email: <email>hwangi@hsph.harvard.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>28</day><month>4</month><year>2008</year></pub-date><pub-date pub-type="ppub"><day>30</day><month>1</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>19</day><month>5</month><year>2008</year></pub-date><volume>23</volume><issue>2</issue><fpage>302</fpage><lpage>305</lpage><abstract><p id="P1">We investigated whether telomere length was associated with the risk of Parkinson’s disease (PD) in a case-control study (96 cases and 172 age-matched controls) nested within the Health Professionals Follow-up Study. Relative ratio of telomere repeat copy number to single-gene copy number in peripheral blood leukocytes was determined by quantitative real time PCR. Men with shorter telomeres had a lower PD risk (multivariate adjusted relative risk for the lowest vs. the highest quartile 0.33; 95% confidence interval: 0.12–0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD.</p></abstract><kwd-group><kwd>nested case-control study</kwd><kwd>Parkinson’s disease</kwd><kwd>telomere length</kwd><kwd>relative risk</kwd></kwd-group><contract-num rid="ES1">Z01 ES101986-02</contract-num><contract-num rid="NS1">R01 NS048517-01A2</contract-num><contract-sponsor id="ES1">National Institute of Environmental Health Sciences : NIEHS</contract-sponsor><contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name><name sortKey="De Vivo, Immaculata" sort="De Vivo, Immaculata" uniqKey="De Vivo I" first="Immaculata" last="De Vivo">Immaculata De Vivo</name><name sortKey="Deer, Dwayne" sort="Deer, Dwayne" uniqKey="Deer D" first="Dwayne" last="Deer">Dwayne Deer</name><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><name sortKey="Mcgrath, Monica" sort="Mcgrath, Monica" uniqKey="Mcgrath M" first="Monica" last="Mcgrath">Monica Mcgrath</name><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name><name sortKey="Wang, Hao" sort="Wang, Hao" uniqKey="Wang H" first="Hao" last="Wang">Hao Wang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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