Examination of the Lille Apathy Rating Scale in Parkinson Disease
Identifieur interne : 000412 ( Pmc/Checkpoint ); précédent : 000411; suivant : 000413Examination of the Lille Apathy Rating Scale in Parkinson Disease
Auteurs : Laura B. Zahodne [États-Unis] ; Shamar Young [États-Unis] ; Lindsey Kirsch-Darrow [États-Unis] ; Anne Nisenzon [États-Unis] ; Hubert H. Fernandez [États-Unis] ; Michael S. Okun [États-Unis] ; Dawn Bowers [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2009.
Abstract
Apathy is a unique, multidimensional syndrome commonly encountered in patients with Parkinson disease (PD). Recently, the Lille Apathy Rating Scale (LARS), a semistructured interview yielding a global score, and composite subscores for different domains of apathy (i.e., cognitive, behavioral, affective, self awareness), was developed and given to a sample of patients with PD in France. This study is the first outside of its original developers to examine the English language version of the LARS in PD. We found the LARS to be a coherent instrument demonstrating both convergent and divergent validity, as compared to the Apathy Scale (AS) and Beck Depression Inventory (BDI-II). Using a receiver operating characteristic (ROC) analysis comparing the LARS to the AS, a validated and widely-used measure, we identified a cut-off score (sensitivity = 64%, specificity = 92%, PPV = 88%, NPV = 75%) that was higher than that proposed by the original authors, who derived their cutoff by comparing LARS global scores to clinical judgments of apathy. Although the present study does not compare the LARS to a diagnostic gold standard or promote its utility for diagnosing apathy, it provides further support for the LARS as a promising instrument to examine apathy in PD.
Url:
DOI: 10.1002/mds.22441
PubMed: 19133658
PubMed Central: 3045860
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:3045860Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Examination of the Lille Apathy Rating Scale in Parkinson Disease</title><author><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B." last="Zahodne">Laura B. Zahodne</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Young, Shamar" sort="Young, Shamar" uniqKey="Young S" first="Shamar" last="Young">Shamar Young</name><affiliation wicri:level="2"><nlm:aff id="A2"> College of Medicine, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> College of Medicine, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Kirsch Darrow, Lindsey" sort="Kirsch Darrow, Lindsey" uniqKey="Kirsch Darrow L" first="Lindsey" last="Kirsch-Darrow">Lindsey Kirsch-Darrow</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Nisenzon, Anne" sort="Nisenzon, Anne" uniqKey="Nisenzon A" first="Anne" last="Nisenzon">Anne Nisenzon</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name><affiliation wicri:level="2"><nlm:aff id="A3"> Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Neurology and Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology and Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19133658</idno><idno type="pmc">3045860</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045860</idno><idno type="RBID">PMC:3045860</idno><idno type="doi">10.1002/mds.22441</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000046</idno><idno type="wicri:Area/Pmc/Curation">000046</idno><idno type="wicri:Area/Pmc/Checkpoint">000412</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Examination of the Lille Apathy Rating Scale in Parkinson Disease</title><author><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B." last="Zahodne">Laura B. Zahodne</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Young, Shamar" sort="Young, Shamar" uniqKey="Young S" first="Shamar" last="Young">Shamar Young</name><affiliation wicri:level="2"><nlm:aff id="A2"> College of Medicine, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> College of Medicine, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Kirsch Darrow, Lindsey" sort="Kirsch Darrow, Lindsey" uniqKey="Kirsch Darrow L" first="Lindsey" last="Kirsch-Darrow">Lindsey Kirsch-Darrow</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Nisenzon, Anne" sort="Nisenzon, Anne" uniqKey="Nisenzon A" first="Anne" last="Nisenzon">Anne Nisenzon</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name><affiliation wicri:level="2"><nlm:aff id="A3"> Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Neurology and Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology and Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Apathy is a unique, multidimensional syndrome commonly encountered in patients with Parkinson disease (PD). Recently, the Lille Apathy Rating Scale (LARS), a semistructured interview yielding a global score, and composite subscores for different domains of apathy (i.e., cognitive, behavioral, affective, self awareness), was developed and given to a sample of patients with PD in France. This study is the first outside of its original developers to examine the English language version of the LARS in PD. We found the LARS to be a coherent instrument demonstrating both convergent and divergent validity, as compared to the Apathy Scale (AS) and Beck Depression Inventory (BDI-II). Using a receiver operating characteristic (ROC) analysis comparing the LARS to the AS, a validated and widely-used measure, we identified a cut-off score (sensitivity = 64%, specificity = 92%, PPV = 88%, NPV = 75%) that was higher than that proposed by the original authors, who derived their cutoff by comparing LARS global scores to clinical judgments of apathy. Although the present study does not compare the LARS to a diagnostic gold standard or promote its utility for diagnosing apathy, it provides further support for the LARS as a promising instrument to examine apathy in PD.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19133658</article-id><article-id pub-id-type="pmc">3045860</article-id><article-id pub-id-type="doi">10.1002/mds.22441</article-id><article-id pub-id-type="manuscript">NIHMS267986</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Examination of the Lille Apathy Rating Scale in Parkinson Disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zahodne</surname><given-names>Laura B.</given-names></name><degrees>MS</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Young</surname><given-names>Shamar</given-names></name><degrees>BS</degrees><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Kirsch-Darrow</surname><given-names>Lindsey</given-names></name><degrees>MS</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Nisenzon</surname><given-names>Anne</given-names></name><degrees>MS</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Fernandez</surname><given-names>Hubert H.</given-names></name><degrees>MD</degrees><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Okun</surname><given-names>Michael S.</given-names></name><degrees>MD</degrees><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Bowers</surname><given-names>Dawn</given-names></name><degrees>PhD</degrees><xref rid="A1" ref-type="aff">1</xref></contrib></contrib-group><aff id="A1"><label>1</label> Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida, USA</aff><aff id="A2"><label>2</label> College of Medicine, University of Florida, Gainesville, Florida, USA</aff><aff id="A3"><label>3</label> Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA</aff><aff id="A4"><label>4</label> Department of Neurology and Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence to: Laura B. Zahodne, Department of Clinical & Health Psychology, University of Florida, PO Box 100165, Gaines-ville, FL 32610-0165. <email>lzahodne@phhp.ufl.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>2</month><year>2011</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>4</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>28</day><month>2</month><year>2011</year></pub-date><volume>24</volume><issue>5</issue><fpage>677</fpage><lpage>683</lpage><abstract><p id="P1">Apathy is a unique, multidimensional syndrome commonly encountered in patients with Parkinson disease (PD). Recently, the Lille Apathy Rating Scale (LARS), a semistructured interview yielding a global score, and composite subscores for different domains of apathy (i.e., cognitive, behavioral, affective, self awareness), was developed and given to a sample of patients with PD in France. This study is the first outside of its original developers to examine the English language version of the LARS in PD. We found the LARS to be a coherent instrument demonstrating both convergent and divergent validity, as compared to the Apathy Scale (AS) and Beck Depression Inventory (BDI-II). Using a receiver operating characteristic (ROC) analysis comparing the LARS to the AS, a validated and widely-used measure, we identified a cut-off score (sensitivity = 64%, specificity = 92%, PPV = 88%, NPV = 75%) that was higher than that proposed by the original authors, who derived their cutoff by comparing LARS global scores to clinical judgments of apathy. Although the present study does not compare the LARS to a diagnostic gold standard or promote its utility for diagnosing apathy, it provides further support for the LARS as a promising instrument to examine apathy in PD.</p></abstract><kwd-group><kwd>Parkinson’s disease</kwd><kwd>apathy</kwd><kwd>rating scales</kwd></kwd-group><contract-num rid="AG1">T32 AG020499-09
||AG</contract-num><contract-sponsor id="AG1">National Institute on Aging : NIA</contract-sponsor></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B." last="Zahodne">Laura B. Zahodne</name></region><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name><name sortKey="Kirsch Darrow, Lindsey" sort="Kirsch Darrow, Lindsey" uniqKey="Kirsch Darrow L" first="Lindsey" last="Kirsch-Darrow">Lindsey Kirsch-Darrow</name><name sortKey="Nisenzon, Anne" sort="Nisenzon, Anne" uniqKey="Nisenzon A" first="Anne" last="Nisenzon">Anne Nisenzon</name><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><name sortKey="Young, Shamar" sort="Young, Shamar" uniqKey="Young S" first="Shamar" last="Young">Shamar Young</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000412 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000412 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:3045860
|texte= Examination of the Lille Apathy Rating Scale in Parkinson Disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:19133658" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |