Enhancing Neuroplasticity in the Basal Ganglia: The Role of Exercise in Parkinson’s Disease
Identifieur interne : 000350 ( Pmc/Checkpoint ); précédent : 000349; suivant : 000351Enhancing Neuroplasticity in the Basal Ganglia: The Role of Exercise in Parkinson’s Disease
Auteurs : Giselle M. Petzinger [États-Unis] ; Beth E. Fisher [États-Unis] ; Jon-Eric Van Leeuwen [États-Unis] ; Marta Vukovic [États-Unis] ; Garnik Akopian [États-Unis] ; Charlie K. Meshul [États-Unis] ; Daniel P. Holschneider [États-Unis] ; Angelo Nacca [États-Unis] ; John P. Walsh [États-Unis] ; Michael W. Jakowec [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
Abstract
Epidemiological and clinical trials have suggested that exercise is beneficial for patients with Parkinson’s disease (PD). However, the underlying mechanisms and potential for disease modification are currently unknown. This review presents current findings from our laboratories in patients with PD and animal models. The data indicate that alterations in both dopaminergic and glutamatergic neurotransmission, induced by activity-dependent (exercise) processes, may mitigate the cortically driven hyper-excitability in the basal ganglia normally observed in the parkinsonian state. These insights have potential to identify novel therapeutic treatments capable of reversing or delaying disease progression in PD.
Url:
DOI: 10.1002/mds.22782
PubMed: 20187247
PubMed Central: 4111643
Affiliations:
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Fisher</name><affiliation wicri:level="4"><nlm:aff id="A2">Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Van Leeuwen, Jon Eric" sort="Van Leeuwen, Jon Eric" uniqKey="Van Leeuwen J" first="Jon-Eric" last="Van Leeuwen">Jon-Eric Van Leeuwen</name><affiliation wicri:level="4"><nlm:aff id="A1">The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Vukovic, Marta" sort="Vukovic, Marta" uniqKey="Vukovic M" first="Marta" last="Vukovic">Marta Vukovic</name><affiliation wicri:level="4"><nlm:aff id="A1">The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Akopian, Garnik" sort="Akopian, Garnik" uniqKey="Akopian G" first="Garnik" last="Akopian">Garnik Akopian</name><affiliation wicri:level="4"><nlm:aff id="A3">Andrus Gerontology Center, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Andrus Gerontology Center, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Meshul, Charlie K" sort="Meshul, Charlie K" uniqKey="Meshul C" first="Charlie K." last="Meshul">Charlie K. Meshul</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Behavioral Neuroscience, Oregon Health and Science University/VA Medical Center, Portland, Oregon, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Behavioral Neuroscience, Oregon Health and Science University/VA Medical Center, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Holschneider, Daniel P" sort="Holschneider, Daniel P" uniqKey="Holschneider D" first="Daniel P." last="Holschneider">Daniel P. 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Walsh</name><affiliation wicri:level="4"><nlm:aff id="A3">Andrus Gerontology Center, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Andrus Gerontology Center, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Jakowec, Michael W" sort="Jakowec, Michael W" uniqKey="Jakowec M" first="Michael W." last="Jakowec">Michael W. Jakowec</name><affiliation wicri:level="4"><nlm:aff id="A1">The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20187247</idno><idno type="pmc">4111643</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111643</idno><idno type="RBID">PMC:4111643</idno><idno type="doi">10.1002/mds.22782</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000219</idno><idno type="wicri:Area/Pmc/Curation">000219</idno><idno type="wicri:Area/Pmc/Checkpoint">000350</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Enhancing Neuroplasticity in the Basal Ganglia: The Role of Exercise in Parkinson’s Disease</title><author><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name><affiliation wicri:level="4"><nlm:aff id="A1">The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Fisher, Beth E" sort="Fisher, Beth E" uniqKey="Fisher B" first="Beth E." last="Fisher">Beth E. Fisher</name><affiliation wicri:level="4"><nlm:aff id="A2">Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Van Leeuwen, Jon Eric" sort="Van Leeuwen, Jon Eric" uniqKey="Van Leeuwen J" first="Jon-Eric" last="Van Leeuwen">Jon-Eric Van Leeuwen</name><affiliation wicri:level="4"><nlm:aff id="A1">The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Vukovic, Marta" sort="Vukovic, Marta" uniqKey="Vukovic M" first="Marta" last="Vukovic">Marta Vukovic</name><affiliation wicri:level="4"><nlm:aff id="A1">The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Akopian, Garnik" sort="Akopian, Garnik" uniqKey="Akopian G" first="Garnik" last="Akopian">Garnik Akopian</name><affiliation wicri:level="4"><nlm:aff id="A3">Andrus Gerontology Center, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Andrus Gerontology Center, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Meshul, Charlie K" sort="Meshul, Charlie K" uniqKey="Meshul C" first="Charlie K." last="Meshul">Charlie K. Meshul</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Behavioral Neuroscience, Oregon Health and Science University/VA Medical Center, Portland, Oregon, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Behavioral Neuroscience, Oregon Health and Science University/VA Medical Center, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Holschneider, Daniel P" sort="Holschneider, Daniel P" uniqKey="Holschneider D" first="Daniel P." last="Holschneider">Daniel P. Holschneider</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Psychiatry, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Nacca, Angelo" sort="Nacca, Angelo" uniqKey="Nacca A" first="Angelo" last="Nacca">Angelo Nacca</name><affiliation wicri:level="4"><nlm:aff id="A6">Department of Radiology, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Walsh, John P" sort="Walsh, John P" uniqKey="Walsh J" first="John P." last="Walsh">John P. Walsh</name><affiliation wicri:level="4"><nlm:aff id="A3">Andrus Gerontology Center, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Andrus Gerontology Center, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Jakowec, Michael W" sort="Jakowec, Michael W" uniqKey="Jakowec M" first="Michael W." last="Jakowec">Michael W. Jakowec</name><affiliation wicri:level="4"><nlm:aff id="A1">The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Epidemiological and clinical trials have suggested that exercise is beneficial for patients with Parkinson’s disease (PD). However, the underlying mechanisms and potential for disease modification are currently unknown. This review presents current findings from our laboratories in patients with PD and animal models. The data indicate that alterations in both dopaminergic and glutamatergic neurotransmission, induced by activity-dependent (exercise) processes, may mitigate the cortically driven hyper-excitability in the basal ganglia normally observed in the parkinsonian state. These insights have potential to identify novel therapeutic treatments capable of reversing or delaying disease progression in PD.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20187247</article-id><article-id pub-id-type="pmc">4111643</article-id><article-id pub-id-type="doi">10.1002/mds.22782</article-id><article-id pub-id-type="manuscript">NIHMS601855</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Enhancing Neuroplasticity in the Basal Ganglia: The Role of Exercise in Parkinson’s Disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Petzinger</surname><given-names>Giselle M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Fisher</surname><given-names>Beth E.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Van Leeuwen</surname><given-names>Jon-Eric</given-names></name><degrees>BSc</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Vukovic</surname><given-names>Marta</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Akopian</surname><given-names>Garnik</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Meshul</surname><given-names>Charlie K.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Holschneider</surname><given-names>Daniel P.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Nacca</surname><given-names>Angelo</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Walsh</surname><given-names>John P.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Jakowec</surname><given-names>Michael W.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>The George and MaryLou Boone Center for Parkinson’s Disease Research, Department of Neurology, University of Southern California, Los Angeles, California, USA</aff><aff id="A2"><label>2</label>Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA</aff><aff id="A3"><label>3</label>Andrus Gerontology Center, University of Southern California, Los Angeles, California, USA</aff><aff id="A4"><label>4</label>Department of Behavioral Neuroscience, Oregon Health and Science University/VA Medical Center, Portland, Oregon, USA</aff><aff id="A5"><label>5</label>Department of Psychiatry, University of Southern California, Los Angeles, California, USA</aff><aff id="A6"><label>6</label>Department of Radiology, University of Southern California, Los Angeles, California, USA</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence to: Dr. Giselle M. Petzinger, Department of Neurology, MCA-241, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033. <email>gpetzinger@surgery.usc.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>12</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="ppub"><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>25</day><month>7</month><year>2014</year></pub-date><volume>25</volume><issue>0 1</issue><fpage>S141</fpage><lpage>S145</lpage><pmc-comment>elocation-id from pubmed: 10.1002/mds.22782</pmc-comment>
<permissions><copyright-statement>© 2010 Movement Disorder Society</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p id="P1">Epidemiological and clinical trials have suggested that exercise is beneficial for patients with Parkinson’s disease (PD). However, the underlying mechanisms and potential for disease modification are currently unknown. This review presents current findings from our laboratories in patients with PD and animal models. The data indicate that alterations in both dopaminergic and glutamatergic neurotransmission, induced by activity-dependent (exercise) processes, may mitigate the cortically driven hyper-excitability in the basal ganglia normally observed in the parkinsonian state. These insights have potential to identify novel therapeutic treatments capable of reversing or delaying disease progression in PD.</p></abstract><kwd-group><kwd>dopamine</kwd><kwd>MPTP</kwd><kwd>animal models</kwd><kwd>treadmill</kwd><kwd>glutamate</kwd><kwd>electrophysiology</kwd><kwd>PET imaging</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Oregon</li></region><settlement><li>Los Angeles</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name></region><name sortKey="Akopian, Garnik" sort="Akopian, Garnik" uniqKey="Akopian G" first="Garnik" last="Akopian">Garnik Akopian</name><name sortKey="Fisher, Beth E" sort="Fisher, Beth E" uniqKey="Fisher B" first="Beth E." last="Fisher">Beth E. Fisher</name><name sortKey="Holschneider, Daniel P" sort="Holschneider, Daniel P" uniqKey="Holschneider D" first="Daniel P." last="Holschneider">Daniel P. Holschneider</name><name sortKey="Jakowec, Michael W" sort="Jakowec, Michael W" uniqKey="Jakowec M" first="Michael W." last="Jakowec">Michael W. Jakowec</name><name sortKey="Jakowec, Michael W" sort="Jakowec, Michael W" uniqKey="Jakowec M" first="Michael W." last="Jakowec">Michael W. Jakowec</name><name sortKey="Meshul, Charlie K" sort="Meshul, Charlie K" uniqKey="Meshul C" first="Charlie K." last="Meshul">Charlie K. Meshul</name><name sortKey="Nacca, Angelo" sort="Nacca, Angelo" uniqKey="Nacca A" first="Angelo" last="Nacca">Angelo Nacca</name><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name><name sortKey="Van Leeuwen, Jon Eric" sort="Van Leeuwen, Jon Eric" uniqKey="Van Leeuwen J" first="Jon-Eric" last="Van Leeuwen">Jon-Eric Van Leeuwen</name><name sortKey="Vukovic, Marta" sort="Vukovic, Marta" uniqKey="Vukovic M" first="Marta" last="Vukovic">Marta Vukovic</name><name sortKey="Walsh, John P" sort="Walsh, John P" uniqKey="Walsh J" first="John P." last="Walsh">John P. Walsh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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