Exercise Elevates Dopamine D2 Receptor in a Mouse Model of Parkinson’s Disease: In Vivo Imaging with [18F]Fallypride
Identifieur interne : 000348 ( Pmc/Checkpoint ); précédent : 000347; suivant : 000349Exercise Elevates Dopamine D2 Receptor in a Mouse Model of Parkinson’s Disease: In Vivo Imaging with [18F]Fallypride
Auteurs : Marta G. Vu Kovi [États-Unis] ; Quanzheng Li [États-Unis] ; Beth Fisher [États-Unis] ; Angelo Nacca [États-Unis] ; Richard M. Leahy [États-Unis] ; John P. Walsh [États-Unis] ; Jogesh Mukherjee [États-Unis] ; Celia Williams [États-Unis] ; Michael W. Jakowec [États-Unis] ; Giselle M. Petzinger [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010.
Abstract
The purpose of the current study was to examine changes in dopamine D2 receptor (DA-D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and
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DOI: 10.1002/mds.23407
PubMed: 20960487
PubMed Central: 3273304
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Vu Kovi</name><affiliation wicri:level="4"><nlm:aff id="A1">Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neuroscience Graduate Program, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Li, Quanzheng" sort="Li, Quanzheng" uniqKey="Li Q" first="Quanzheng" last="Li">Quanzheng Li</name><affiliation wicri:level="4"><nlm:aff id="A3">Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viterbi School of Engineering, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Fisher, Beth" sort="Fisher, Beth" uniqKey="Fisher B" first="Beth" last="Fisher">Beth Fisher</name><affiliation wicri:level="4"><nlm:aff id="A4">Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Nacca, Angelo" sort="Nacca, Angelo" uniqKey="Nacca A" first="Angelo" last="Nacca">Angelo Nacca</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Radiology, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Leahy, Richard M" sort="Leahy, Richard M" uniqKey="Leahy R" first="Richard M." last="Leahy">Richard M. Leahy</name><affiliation wicri:level="4"><nlm:aff id="A3">Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viterbi School of Engineering, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Walsh, John P" sort="Walsh, John P" uniqKey="Walsh J" first="John P." last="Walsh">John P. Walsh</name><affiliation wicri:level="4"><nlm:aff id="A6">Andrus Gerontology Center, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Andrus Gerontology Center, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Mukherjee, Jogesh" sort="Mukherjee, Jogesh" uniqKey="Mukherjee J" first="Jogesh" last="Mukherjee">Jogesh Mukherjee</name><affiliation wicri:level="2"><nlm:aff id="A7">Preclinical Imaging Center, Department of Psychiatry and Human Behavior, UC Irvine, Irvine, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Preclinical Imaging Center, Department of Psychiatry and Human Behavior, UC Irvine, Irvine, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Williams, Celia" sort="Williams, Celia" uniqKey="Williams C" first="Celia" last="Williams">Celia Williams</name><affiliation wicri:level="4"><nlm:aff id="A2">The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Jakowec, Michael W" sort="Jakowec, Michael W" uniqKey="Jakowec M" first="Michael W." last="Jakowec">Michael W. Jakowec</name><affiliation wicri:level="4"><nlm:aff id="A2">The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A4">Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name><affiliation wicri:level="4"><nlm:aff id="A2">The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A4">Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20960487</idno><idno type="pmc">3273304</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273304</idno><idno type="RBID">PMC:3273304</idno><idno type="doi">10.1002/mds.23407</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000156</idno><idno type="wicri:Area/Pmc/Curation">000156</idno><idno type="wicri:Area/Pmc/Checkpoint">000348</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Exercise Elevates Dopamine D2 Receptor in a Mouse Model of Parkinson’s Disease: In Vivo Imaging with [<sup>18</sup>F]Fallypride</title><author><name sortKey="Vu Kovi, Marta G" sort="Vu Kovi, Marta G" uniqKey="Vu Kovi M" first="Marta G." last="Vu Kovi">Marta G. Vu Kovi</name><affiliation wicri:level="4"><nlm:aff id="A1">Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neuroscience Graduate Program, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Li, Quanzheng" sort="Li, Quanzheng" uniqKey="Li Q" first="Quanzheng" last="Li">Quanzheng Li</name><affiliation wicri:level="4"><nlm:aff id="A3">Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viterbi School of Engineering, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Fisher, Beth" sort="Fisher, Beth" uniqKey="Fisher B" first="Beth" last="Fisher">Beth Fisher</name><affiliation wicri:level="4"><nlm:aff id="A4">Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Nacca, Angelo" sort="Nacca, Angelo" uniqKey="Nacca A" first="Angelo" last="Nacca">Angelo Nacca</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Radiology, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Leahy, Richard M" sort="Leahy, Richard M" uniqKey="Leahy R" first="Richard M." last="Leahy">Richard M. Leahy</name><affiliation wicri:level="4"><nlm:aff id="A3">Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viterbi School of Engineering, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Walsh, John P" sort="Walsh, John P" uniqKey="Walsh J" first="John P." last="Walsh">John P. Walsh</name><affiliation wicri:level="4"><nlm:aff id="A6">Andrus Gerontology Center, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Andrus Gerontology Center, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Mukherjee, Jogesh" sort="Mukherjee, Jogesh" uniqKey="Mukherjee J" first="Jogesh" last="Mukherjee">Jogesh Mukherjee</name><affiliation wicri:level="2"><nlm:aff id="A7">Preclinical Imaging Center, Department of Psychiatry and Human Behavior, UC Irvine, Irvine, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Preclinical Imaging Center, Department of Psychiatry and Human Behavior, UC Irvine, Irvine, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Williams, Celia" sort="Williams, Celia" uniqKey="Williams C" first="Celia" last="Williams">Celia Williams</name><affiliation wicri:level="4"><nlm:aff id="A2">The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Jakowec, Michael W" sort="Jakowec, Michael W" uniqKey="Jakowec M" first="Michael W." last="Jakowec">Michael W. Jakowec</name><affiliation wicri:level="4"><nlm:aff id="A2">The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A4">Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name><affiliation wicri:level="4"><nlm:aff id="A2">The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A4">Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author></analytic><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The purpose of the current study was to examine changes in dopamine D2 receptor (DA-D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and <italic>in vivo</italic> positron emission tomography (PET) imaging employing the DA-D2R specific ligand [<sup>18</sup>F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA-D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise-induced changes in the DA-D2R in the dopamine-depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [<sup>18</sup>F]fallypride to examine DA-D2R changes in individuals with Parkinson’s Disease (PD) undergoing high-intensity treadmill training.</p></div></front></TEI><pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-title-group><journal-title>Movement Disorders</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20960487</article-id><article-id pub-id-type="pmc">3273304</article-id><article-id pub-id-type="doi">10.1002/mds.23407</article-id><article-id pub-id-type="manuscript">NIHMS347747</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Exercise Elevates Dopamine D2 Receptor in a Mouse Model of Parkinson’s Disease: In Vivo Imaging with [<sup>18</sup>F]Fallypride</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Vučković</surname><given-names>Marta G.</given-names></name><degrees>MSc</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Quanzheng</given-names></name><degrees>PhD</degrees><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Fisher</surname><given-names>Beth</given-names></name><degrees>PT, PhD</degrees><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Nacca</surname><given-names>Angelo</given-names></name><degrees>PhD</degrees><xref rid="A5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Leahy</surname><given-names>Richard M.</given-names></name><degrees>PhD</degrees><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Walsh</surname><given-names>John P.</given-names></name><degrees>PhD</degrees><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Mukherjee</surname><given-names>Jogesh</given-names></name><degrees>PhD</degrees><xref rid="A7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Williams</surname><given-names>Celia</given-names></name><degrees>BSc</degrees><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Jakowec</surname><given-names>Michael W.</given-names></name><degrees>PhD</degrees><xref rid="A2" ref-type="aff">2</xref><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Petzinger</surname><given-names>Giselle M.</given-names></name><degrees>MD</degrees><xref rid="A2" ref-type="aff">2</xref><xref rid="A4" ref-type="aff">4</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA</aff><aff id="A2"><label>2</label>The George and Mary Lou Boone Center for Parkinson’s Disease Research, Department of Neurology; University of Southern California, Los Angeles, California, USA</aff><aff id="A3"><label>3</label>Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA</aff><aff id="A4"><label>4</label>Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA</aff><aff id="A5"><label>5</label>Department of Radiology, University of Southern California, Los Angeles, California, USA</aff><aff id="A6"><label>6</label>Andrus Gerontology Center, University of Southern California, Los Angeles, California, USA</aff><aff id="A7"><label>7</label>Preclinical Imaging Center, Department of Psychiatry and Human Behavior, UC Irvine, Irvine, California, USA</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence to: Dr. Giselle Petzinger, Department of Neurology, University of Southern California, 1333 San Pablo St. MCA 241, Los Angeles, CA 90033. <email>petzinge@surgery.usc.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>6</day><month>1</month><year>2012</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>12</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>6</day><month>2</month><year>2012</year></pub-date><volume>25</volume><issue>16</issue><fpage>2777</fpage><lpage>2784</lpage><permissions><copyright-statement>© 2010 Movement Disorder Society</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p id="P1">The purpose of the current study was to examine changes in dopamine D2 receptor (DA-D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and <italic>in vivo</italic> positron emission tomography (PET) imaging employing the DA-D2R specific ligand [<sup>18</sup>F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA-D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise-induced changes in the DA-D2R in the dopamine-depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [<sup>18</sup>F]fallypride to examine DA-D2R changes in individuals with Parkinson’s Disease (PD) undergoing high-intensity treadmill training.</p></abstract><kwd-group><kwd>positron emission tomography</kwd><kwd>basal ganglia</kwd><kwd>neuroplasticity</kwd><kwd>treadmill exercise</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>R01 NS044327-05A2 || NS</award-id></award-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>R01 NS044327-04 || NS</award-id></award-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>R01 NS044327-03 || NS</award-id></award-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>R01 NS044327-02 || NS</award-id></award-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>R01 NS044327-01 || NS</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Los Angeles</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Vu Kovi, Marta G" sort="Vu Kovi, Marta G" uniqKey="Vu Kovi M" first="Marta G." last="Vu Kovi">Marta G. Vu Kovi</name></region><name sortKey="Fisher, Beth" sort="Fisher, Beth" uniqKey="Fisher B" first="Beth" last="Fisher">Beth Fisher</name><name sortKey="Jakowec, Michael W" sort="Jakowec, Michael W" uniqKey="Jakowec M" first="Michael W." last="Jakowec">Michael W. Jakowec</name><name sortKey="Jakowec, Michael W" sort="Jakowec, Michael W" uniqKey="Jakowec M" first="Michael W." last="Jakowec">Michael W. Jakowec</name><name sortKey="Leahy, Richard M" sort="Leahy, Richard M" uniqKey="Leahy R" first="Richard M." last="Leahy">Richard M. Leahy</name><name sortKey="Li, Quanzheng" sort="Li, Quanzheng" uniqKey="Li Q" first="Quanzheng" last="Li">Quanzheng Li</name><name sortKey="Mukherjee, Jogesh" sort="Mukherjee, Jogesh" uniqKey="Mukherjee J" first="Jogesh" last="Mukherjee">Jogesh Mukherjee</name><name sortKey="Nacca, Angelo" sort="Nacca, Angelo" uniqKey="Nacca A" first="Angelo" last="Nacca">Angelo Nacca</name><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name><name sortKey="Vu Kovi, Marta G" sort="Vu Kovi, Marta G" uniqKey="Vu Kovi M" first="Marta G." last="Vu Kovi">Marta G. Vu Kovi</name><name sortKey="Walsh, John P" sort="Walsh, John P" uniqKey="Walsh J" first="John P." last="Walsh">John P. Walsh</name><name sortKey="Williams, Celia" sort="Williams, Celia" uniqKey="Williams C" first="Celia" last="Williams">Celia Williams</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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