Milestones in Research on the Pathophysiology of Parkinson’s Disease
Identifieur interne : 000254 ( Pmc/Checkpoint ); précédent : 000253; suivant : 000255Milestones in Research on the Pathophysiology of Parkinson’s Disease
Auteurs : Thomas Wichmann [États-Unis] ; Mahlon R. Delong [États-Unis] ; Jorge Guridi [Espagne] ; Jose A. Obeso [Espagne]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2011.
Abstract
Progress in our understanding of the mechanisms underlying the cardinal motor abnormalities of Parkinson’s disease (PD), in particular akinesia and bradykinesia and their treatment, has been remarkable. Notable accomplishments include insights into the functional organization of the basal ganglia and their place in the motor system as components of a family of parallel cortico-subcortical circuits that subserve motor and nonmotor functions and the development of models of the intrinsic organization of the basal ganglia, including delineation of the so-called direct, indirect, and hyperdirect pathways. Studies in primate models of PD have provided insight into the alterations of neuronal activity that are responsible for the motor features of PD, revealing both altered tonic levels of discharge and significant disturbances of the patterns of discharge throughout the motor circuitry and have led to the formulation of circuit models of PD, providing testable hypotheses for research and stimulating the development of new therapies. Most importantly, the discovery that lesions of the subthalamic nucleus, a key node of the indirect pathway, abolish the cardinal features of PD contributed to the renaissance in the use of surgical approaches to treating patients with PD, including ablation and deep brain stimulation.
Url:
DOI: 10.1002/mds.23695
PubMed: 21626548
PubMed Central: 4272856
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:4272856Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Milestones in Research on the Pathophysiology of Parkinson’s Disease</title>
<author><name sortKey="Wichmann, Thomas" sort="Wichmann, Thomas" uniqKey="Wichmann T" first="Thomas" last="Wichmann">Thomas Wichmann</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Yerkes National Primate Center at Emory University, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Yerkes National Primate Center at Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delong, Mahlon R" sort="Delong, Mahlon R" uniqKey="Delong M" first="Mahlon R." last="Delong">Mahlon R. Delong</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra, Pamplona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Santander, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Santander</wicri:regionArea>
<wicri:noRegion>Santander</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra, Pamplona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Santander, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Santander</wicri:regionArea>
<wicri:noRegion>Santander</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21626548</idno>
<idno type="pmc">4272856</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272856</idno>
<idno type="RBID">PMC:4272856</idno>
<idno type="doi">10.1002/mds.23695</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">000243</idno>
<idno type="wicri:Area/Pmc/Curation">000243</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000254</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Milestones in Research on the Pathophysiology of Parkinson’s Disease</title>
<author><name sortKey="Wichmann, Thomas" sort="Wichmann, Thomas" uniqKey="Wichmann T" first="Thomas" last="Wichmann">Thomas Wichmann</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Yerkes National Primate Center at Emory University, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Yerkes National Primate Center at Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delong, Mahlon R" sort="Delong, Mahlon R" uniqKey="Delong M" first="Mahlon R." last="Delong">Mahlon R. Delong</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra, Pamplona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Santander, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Santander</wicri:regionArea>
<wicri:noRegion>Santander</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra, Pamplona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Santander, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Santander</wicri:regionArea>
<wicri:noRegion>Santander</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Progress in our understanding of the mechanisms underlying the cardinal motor abnormalities of Parkinson’s disease (PD), in particular akinesia and bradykinesia and their treatment, has been remarkable. Notable accomplishments include insights into the functional organization of the basal ganglia and their place in the motor system as components of a family of parallel cortico-subcortical circuits that subserve motor and nonmotor functions and the development of models of the intrinsic organization of the basal ganglia, including delineation of the so-called direct, indirect, and hyperdirect pathways. Studies in primate models of PD have provided insight into the alterations of neuronal activity that are responsible for the motor features of PD, revealing both altered tonic levels of discharge and significant disturbances of the patterns of discharge throughout the motor circuitry and have led to the formulation of circuit models of PD, providing testable hypotheses for research and stimulating the development of new therapies. Most importantly, the discovery that lesions of the subthalamic nucleus, a key node of the indirect pathway, abolish the cardinal features of PD contributed to the renaissance in the use of surgical approaches to treating patients with PD, including ablation and deep brain stimulation.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
<journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id>
<journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title>
</journal-title-group>
<issn pub-type="ppub">0885-3185</issn>
<issn pub-type="epub">1531-8257</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21626548</article-id>
<article-id pub-id-type="pmc">4272856</article-id>
<article-id pub-id-type="doi">10.1002/mds.23695</article-id>
<article-id pub-id-type="manuscript">NIHMS650227</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Milestones in Research on the Pathophysiology of Parkinson’s Disease</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Wichmann</surname>
<given-names>Thomas</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>DeLong</surname>
<given-names>Mahlon R.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guridi</surname>
<given-names>Jorge</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Obeso</surname>
<given-names>Jose A.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia, USA</aff>
<aff id="A2"><label>2</label>
Yerkes National Primate Center at Emory University, Atlanta, Georgia, USA</aff>
<aff id="A3"><label>3</label>
Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra, Pamplona, Spain</aff>
<aff id="A4"><label>4</label>
Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Santander, Spain</aff>
<author-notes><corresp id="cor1"><label>*</label>
<bold>Correspondence to:</bold>
Dr. Thomas Wichmann, Yerkes National Primate Center, Division of Neuropharmacology and Neurologic Diseases, 954 Gatewood Road, Atlanta, GA 30322, USA; <email>twichma@emory.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>18</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>5</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>21</day>
<month>12</month>
<year>2014</year>
</pub-date>
<volume>26</volume>
<issue>6</issue>
<fpage>1032</fpage>
<lpage>1041</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/mds.23695</pmc-comment>
<permissions><copyright-statement>© 2011 <italic>Movement</italic>
Disorder Society</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><p id="P1">Progress in our understanding of the mechanisms underlying the cardinal motor abnormalities of Parkinson’s disease (PD), in particular akinesia and bradykinesia and their treatment, has been remarkable. Notable accomplishments include insights into the functional organization of the basal ganglia and their place in the motor system as components of a family of parallel cortico-subcortical circuits that subserve motor and nonmotor functions and the development of models of the intrinsic organization of the basal ganglia, including delineation of the so-called direct, indirect, and hyperdirect pathways. Studies in primate models of PD have provided insight into the alterations of neuronal activity that are responsible for the motor features of PD, revealing both altered tonic levels of discharge and significant disturbances of the patterns of discharge throughout the motor circuitry and have led to the formulation of circuit models of PD, providing testable hypotheses for research and stimulating the development of new therapies. Most importantly, the discovery that lesions of the subthalamic nucleus, a key node of the indirect pathway, abolish the cardinal features of PD contributed to the renaissance in the use of surgical approaches to treating patients with PD, including ablation and deep brain stimulation.</p>
</abstract>
<kwd-group><kwd>basal ganglia</kwd>
<kwd>direct pathway</kwd>
<kwd>indirect pathway</kwd>
<kwd>dyskinesias</kwd>
<kwd>deep brain stimulation</kwd>
<kwd>pallidotomy</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Espagne</li>
<li>États-Unis</li>
</country>
<region><li>Géorgie (États-Unis)</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Wichmann, Thomas" sort="Wichmann, Thomas" uniqKey="Wichmann T" first="Thomas" last="Wichmann">Thomas Wichmann</name>
</region>
<name sortKey="Delong, Mahlon R" sort="Delong, Mahlon R" uniqKey="Delong M" first="Mahlon R." last="Delong">Mahlon R. Delong</name>
<name sortKey="Wichmann, Thomas" sort="Wichmann, Thomas" uniqKey="Wichmann T" first="Thomas" last="Wichmann">Thomas Wichmann</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name>
</noRegion>
<name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name>
<name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name>
<name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000254 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000254 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:4272856 |texte= Milestones in Research on the Pathophysiology of Parkinson’s Disease }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:21626548" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
![]() | This area was generated with Dilib version V0.6.23. | ![]() |